Abstract
Many bacteria responsible for human diseases are not pathogens in the strictest sense; rather they are commensal organisms which cause disease as a consequence of a failed or dysfunctional interaction with their host. For the pediatrician Neisseria meningitidis, the meningococcus, is perhaps the most dramatic example of such an organism. Indeed, the designation of the meningococcus as a commensal may appear to be strange or even ridiculous from a clinical perspective. Meningococcal disease, comprising the two syndromes meningitis and septicemia, is one of the most dangerous conditions that a pediatrician is likely to encounter (Brandtzaeg, 1995). Its dramatic symptoms, together with the rapidity with which it progresses, contribute to the reputation of the meningococcus as a more than usually aggressive pathogen. However, meningococcal disease is very rare relative to the universal presence of asymptomatic meningococcal carriage in human populations (Broome, 1986).
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References
Artenstein, M.S., Gold, R., Zimmerly, J.G., Wyle, F.A., Schneider, H., and Harkins, C. (1970). Prevention of meningococcal disease by group C polysaccharide vaccine. N. Engl. J. Med. 282, 417–420.
Balmer, P., Borrow, R., and Miller, E. (2002). Impact of meningococcal C vaccine in the UK. J. Med. Microbiol. 51, 717–722.
Brandtzaeg, P. (1995). Pathogenesis of Meningococcal Infections. In K.A.V. Cartwright (ed.) Meningococcal disease. John Wiley and Sons, Chichester, pp. 71–114.
Broome, C.V. (1986). The carrier state: Neisseria meningitidis. J. Antimicrob. Chemother. 18(Suppl A), 25–34.
Brundage, J.F. and Zollinger, W.D. (1987). Evolution of meningococcal disease epidemiology in the US army. In N. A. Vedros (ed.) Evolution of meningococcal disease, Vol. I. CRC Press, Boca Raton, FL, pp. 5–25.
Cartwright, K.A.V., Stuart, J.M., Jones, D.M., and Noah, N.D. (1987). The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol. Infect. 99, 591–601.
Caugant, D.A. (1998). Population genetics and molecular epidemiology of Neisseria meningitidis. Apmis 106, 505–525.
Caugant, D.A., Bovre, K., Gaustad, P., Bryn, K., Holten, E., H0iby, E.A., and Fr0holm, L.O. (1986a). Multilocus genotype determined by enzyme electrophoresis of Neisseria meningitidis isolated from patients with systemic disease and from healthy carriers. J. Gen. Microbiol. 132, 641–652.
Caugant, D.A., Frøholm, L.O., Bovre, K., Holten, E., Frasch, C.E., Mocca, L.F. et al. (1986b). Intercontinental spread of a genetically distinctive complex of clones of Neisseria meningitidis causing epidemic disease. Proc. Natl. Acad. Sci. USA 83, 4927–4931.
Caugant, D.A., Kristiansen, B.E., Frøholm, L.O., Bovre, K., and Seiander, R.K. (1988). Clonal diversity of Neisseria meningitidis from a population of asymptomatic carriers. Infect. Immun. 56, 2060–2068.
Claus, H., Maiden, M.C., Maag, R., Frosch, M., and Vogel, U. (2002). Many carried meningococci lack the genes required for capsule synthesis and transport. Microbiology 148, 1813–1819.
Dolan-Livengood, J.M., Miller, Y.K., Martin, L.E., Urwin, R., and Stephens, D.S. (2003). Genetic basis for non-groupable Neisseria meningitidis. J. Infect. Dis. 187, 1616–1628.
Finne, J., Leinonen, M., and Makela, P.H. (1983). Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis. Lancet 2, 355–357.
Frasch, C.E., Tsai, C.-M., and Mocca, L.F. (1986). Outer Membrane Proteins of Neisseria meningitidis: Structure and importance in Meningococcal Disease. Clin. Invest. Med. 9, 101–107.
Gold, R., Goldschneider, I., Lepow, M.L., Draper, T.F., and Randolph, M. (1978). Carriage of Neisseria meningitides and Neisseria lactamica in infants and children. J. Infect. Dis. 137, 112–121.
Gotschlich, E.C., Goldschneider, I., and Artenstein, M.S. (1969). Human immunity ot the meningococcus IV. Immunogenicity of group A and group C meningococcal polysaccharides. J. Exp. Med. 129, 1367–1384.
Jennings, H.J. and Lugowski, C. (1981). Immunochemistry of groups A, B, and C meningoccal polysaccharide-tetanus toxoid conjugates. J. Immunol. 127, 1011–1018.
Jodar, L., Feavers, I.M., Salisbury, D., and Granoff, D.M. (2002). Development of vaccines against meningococcal disease. Lancet 359, 1499–1508.
Jones, D.M. and Mallard, R.H. (1993). Age incidence of meningococcal infection England and Wales 1984-1991. J Infect. 27, 83–88.
Maiden, M.C. and Stuart, J.M. (2002). Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination. Lancet 359, 1829–1831.
Maiden, M.C.J., Bygraves, J.A., Feil, E., Morelli, G., Russell, J.E., Urwin, R. et al. (1998). Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc. Natl. Acad. Sci. USA 95, 3140–3145.
Maiden, M.C.J., and Spratt, B.G. (1999). Meningococcal conjugate vaccines: new opportunities and new challenges. Lancet 354, 615–616.
Miller, E., Salisbury, D., and Ramsay, M. (2001). Planning, registration, and implementation of an immunisation campaign against meningococcal serogroup C disease in the UK: a success story. Vaccine 20(Suppl 1), S58–67.
Peltola, H. (1983). Meningococcal disease: still with us. Rev. Infect. Dis. 5, 71–91.
Popovic, T., Sacchi, C.T., Reeves, M.W., Whitney, A.M., Mayer, L.W., Noble, C.A. et al. (2000). Neisseria meningitidis serogroup W135 isolates associated with the ET-37 complex. Emerg. Infect. Dis. 6, 428–429.
Ramsay, M.E., Andrews, N., Kaczmarski, E.B., and Miller, E. (2001). Efficacy of meningococcal serogroup C conjugate vaccine in teenagers and toddlers in England. Lancet 357, 195–196.
Stuart, J.M., Cartwright, K.A., Robinson, P.M., and Noah, N.D. (1989) Effect of smoking on meningoccal carriage. Lancet 2, 723–725.
Tsai, C.M., Mocca, L.F., and Frasch, C.E. (1987). Immunotype epitopes of Neisseria meningitidis lipooligosaccharide types 1 through 8. Infect. Immun. 55, 1652–1656.
Vedros, N.A. (1987). Development of meningococcal serogroups. In N.A. Vedros (ed.) Evolution of meningococcal disease, Vol. II. CRC Press Inc., Boca Raton, FL, pp. 33–37.
Wang, J.-F., Caugant, D.A., Morelli, G., Koumare, B., and Achtman, M. (1993). Antigenic and epidemiological properties of the ET-37 complex of Neisseria meningitis. J. Infect. Dis. 167, 1320–1329.
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Maiden, M.C.J. (2004). Dynamics of Bacterial Carriage and Disease: Lessons from the Meningococcus. In: Pollard, A.J., McCracken, G.H., Finn, A. (eds) Hot Topics in Infection and Immunity in Children. Advances in Experimental Medicine and Biology, vol 549. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8993-2_5
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DOI: https://doi.org/10.1007/978-1-4419-8993-2_5
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