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GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression

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Adhesion-GPCRs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 706))

Abstract

GPR56 is a relatively recent addition to the adhesion-GPCR family. Genetic and biochemical studies uncovered its roles in cancer and development and established its function as an adhesion receptor to mediate the interactions between cells and extracellular matrix. Despite of much progress on understanding its biological implications, the mechanism of its function remains elusive. It has not been firmly established whether GPR56 signals directly through G proteins and what its upstream stimuli and downstream effectors are to execute its various biological effects. This chapter will give an overview of the primary structures of the Gpr56 gene and its encoded protein and attempt to point out open questions in this research area, with an emphasis on its roles in cancer and signal transduction.

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Author information

Authors and Affiliations

  1. Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA

    Lei Xu

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  1. Lei Xu
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Editor information

Editors and Affiliations

  1. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Simon Yona PhD

  2. Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

    Martin Stacey DPhil

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© 2010 Landes Bioscience and Springer Science+Business Media, LLC

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Xu, L. (2010). GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_8

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