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The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans

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Enzyme- and Transporter-Based Drug-Drug Interactions

Abstract

Drug transport proteins have been recognized as significant contributors to drug absorption, distribution, elimination, toxicity, and efficacy. This chapter will discuss the key concepts of transporter-based drug–drug interactions (DDIs), provide a concise review of DDIs involving the major drug transporters, and describe methodologies used to quantitatively predict the magnitude of transporter-based DDIs in humans.

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Acknowledgments

This work was supported by NIH grants GM032165 and GM54447. Brian Kirby was supported in part by an ARCS fellowship and an NIH Pharmacological Sciences training grant (GM07550).

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA

    Jashvant D. Unadkat

  2. Department of Pharmaceutics, University of Washington, Seattle, WA, USA

    Brian J. Kirby, Christopher J. Endres & Joseph K. Zolnerciks

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  1. Jashvant D. Unadkat
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  2. Brian J. Kirby
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  3. Christopher J. Endres
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  4. Joseph K. Zolnerciks
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Correspondence to Jashvant D. Unadkat .

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  1. Leslie Dan Fac. Pharmacy, University of Toronto, College Street 144, Toronto, M5S 3M2, Canada

    K. Sandy Pang

  2. Bristol-Myers Squibb Company, Princeton, 08543, U.S.A.

    A. David Rodrigues

  3. AstraZeneca UK, Alderley Park, Macclesfield, Cheshire, SK10 4TF, United Kingdom

    Raimund M. Peter

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Unadkat, J.D., Kirby, B.J., Endres, C.J., Zolnerciks, J.K. (2010). The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans. In: Pang , K., Rodrigues, A., Peter, R. (eds) Enzyme- and Transporter-Based Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0840-7_21

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