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Functional MRI Studies of Memory in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

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Functional Neuroradiology

Abstract

In the human brain, functionally and anatomically defined systems exist for encoding, consolidating, and retrieving memories of experiences (episodic memory); accumulating and accessing factual information in a body of knowledge (semantic memory); and actively processing and manipulating information (working memory). These three memory systems can be distinguished from other nondeclarative memory systems such as procedural learning and priming [1–4]. Brain-behavior studies using a variety of approaches from lesion-based research to functional magnetic resonance imaging (fMRI) demonstrate distinct though highly interrelated neural circuitry for episodic, semantic, and working memory [3, 5]. Each of these memory systems, despite their close interaction, is affected somewhat differently by aging and dementia.

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Acknowledgements

Supported in part by the following grants from: the National Institutes of Health (CTSI Training Grant, TL1 RR025759 to SLR; NIA R01 AG19771 and NIH R01 CA101318 to AJS; Indiana Alzheimer’s Disease Center, P30 AG10133-18S1 Core Supplement to Drs. B. Ghetti and AJS); the Alzheimer’s Disease Neuroimaging Initiative (NIH U01 AG024904 and RC2 AG036535-01); the Indiana Economic Development Corporation (IEDC #87884 to AJS); and the Alzheimer’s Association.

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Authors and Affiliations

  1. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IU Center for Neuroimaging, 950 West Walnut Street, R2, E124, Indianapolis, IN, 46202, USA

    Shannon L. Risacher BS

  2. Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH, 03756, USA

    Heather A. Wishart PhD

  3. Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN, 46202, USA

    Andrew J. Saykin PsyD, ABPP/CN

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  1. Shannon L. Risacher BS
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  2. Heather A. Wishart PhD
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  3. Andrew J. Saykin PsyD, ABPP/CN
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Correspondence to Andrew J. Saykin PsyD, ABPP/CN .

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Editors and Affiliations

  1. Temple University School of Medicine, 3401 Broad Street, Philadelphia, 19140-5189, Pennsylvania, USA

    Scott H. Faro

  2. Dept. of Radiology, Temple University Hospital, 3401 Broad Street, Philadelphia, 19140-5189, Pennsylvania, USA

    Feroze B. Mohamed

  3. , Radiology, University of Southern California School, Zonal Avenue 1975, Los Angeles, 90033, California, USA

    Meng Law

  4. , Department of Radiology, Medical College of Wisconsin, Watertown Plank Road 8701, Milwaukee, 53226, USA

    John T. Ulmer

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Risacher, S.L., Wishart, H.A., Saykin, A.J. (2011). Functional MRI Studies of Memory in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease. In: Faro, S., Mohamed, F., Law, M., Ulmer, J. (eds) Functional Neuroradiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0345-7_24

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  • DOI: https://doi.org/10.1007/978-1-4419-0345-7_24

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