Abstract
The identification of non-canonical UCP1-independent thermogenic mechanisms offers new opportunities to target such pathways to improve metabolic health. Based on our recent studies on Ca2+ futile cycling thermogenesis in beige fat, we applied the newly developed implantable wireless optogenetic system to activate Ca2+ cycling in an adipocyte-specific manner without external stimuli, i.e., fat-specific cold mimetics. Here, we describe the detailed methodology and application to the prevention of obesity.
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Ikeda, K., Tajima, K., Tanabe, Y., Poon, A.S.Y., Kajimura, S. (2022). Activation of UCP1-Independent Ca2+ Cycling Thermogenesis by Wireless Optogenetics. In: Guertin, D.A., Wolfrum, C. (eds) Brown Adipose Tissue. Methods in Molecular Biology, vol 2448. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2087-8_9
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DOI: https://doi.org/10.1007/978-1-0716-2087-8_9
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