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Genome Sequencing in Esophageal Squamous Cell Carcinoma

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Esophageal Squamous Cell Carcinoma

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2129))

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Abstract

Technological advances in the form of next-generation sequencing allow sequencing of large numbers of different DNA sequences in a single/parallel reaction compared to conventional sequencing. It is a powerful tool which has enabled comprehensive characterization of esophageal squamous cell carcinoma. Whole-genome sequencing is the most comprehensive but expensive, whereas whole-exome sequencing is cost-effective, but it only works for the known genes. Thus, second-generation sequencing methods can provide a complete picture of the esophageal squamous cell carcinoma genome by detecting and discovering different type of alterations in the cancer which may lead to the development of effective diagnostic and therapeutic approaches for esophageal squamous cell carcinoma.

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Author information

Authors and Affiliations

  1. School of Biomedical Science, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia

    Suja Pillai

  2. Genomics Research Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

    Neven Maksemous

  3. Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland, Australia

    Alfred K. Lam

Authors
  1. Suja Pillai
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  2. Neven Maksemous
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  3. Alfred K. Lam
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Corresponding author

Correspondence to Alfred K. Lam .

Editor information

Editors and Affiliations

  1. Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, QLD, Australia

    Alfred K. Lam

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Pillai, S., Maksemous, N., Lam, A.K. (2020). Genome Sequencing in Esophageal Squamous Cell Carcinoma. In: Lam, A. (eds) Esophageal Squamous Cell Carcinoma. Methods in Molecular Biology, vol 2129. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0377-2_17

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  • DOI: https://doi.org/10.1007/978-1-0716-0377-2_17

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0376-5

  • Online ISBN: 978-1-0716-0377-2

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