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Dendritic Cell Vaccines in Cancer: Obstaclesto Overcome

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Dendritic Cells in Cancer

Abstract

Significant progress has been made in the development of cancer immunotherapies. However, as advances continue to unravel the complexity of the immune system and processes involved in the induction of antitumor immunity and tolerance, new questions increasingly arise. Various approaches have been undertaken in an effort to induce efficient antitumor immunity. Dendritic cells are the most potent antigen-presenting cells known, and this capacity of dendritic cells has been exploited against various malignancies under different conditions. This chapter reviews various controversies in dendritic cell-based vaccine development, including sources of dendritic cells, their differentiation, maturation and antigen loading, vaccine delivery, as well as effective monitoring of the immune and clinical responses in vivo.

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  1. Cutaneous Oncology and Photopheresis Center, University of Pittsburgh School of Medicine, 190 Lothrop Street, Lothrop Hall, Suite 101, Pittsburgh, PA 15213, USA

    Larisa J. Geskin

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  1. Ezra D. Mirvish
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  2. Rebecca G. Pomerantz
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  3. Louis D. Falo
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    Mirvish, E.D., Pomerantz, R.G., Falo, L.D., Geskin, L.J. (2009). Dendritic Cell Vaccines in Cancer: Obstaclesto Overcome. In: Salter, R., Shurin, M. (eds) Dendritic Cells in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-88611-4_21

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