Hypoglossal motoneurons (HMs) receive serotonergic innervations from medullary raphe neurons and produce rhythmic discharge patterns closely associated with respiratory rhythm generated in the pre-Bötzinger complex (pBC). HM activity is subject to modulation by numerous factors including serotonin (5-HT), TRH, norepinephrine (NE), substance P (SP), pH, multiple protein kinases and phosphatases. In this present work, we introduce a computational HM model that facilitates the investigation of how neuromodulatory factors. such as 5-HT and pH, can affect HM activities.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bayliss, D.A., Viana, F., Talley, E.M. and Berger, A.J. (1997) Neuromodulation of hypoglossal motoneurons: cellular and developmental mechanisms. Respir. Physiol. 110, 139–150.
Berg, A.P., Talley, E.M., Manger, J.P. and Bayliss, D.A. (2004) Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits. J. Neurosci. 24, 6693–6702.
Cuthbertson, K.S. and Chay, T.R. (1991) Modelling receptor-controlled intracellular calcium oscillators. Cell Calcium 12, 97–109.
Feldman, J.L., Neverova, N.V. and Saywell, S.A. (2005) Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respir. Physiol. Neurobiol. 147, 131–143.
Ladewig, T., Kloppenburg, P., Lalley, P.M., Zipfel, W.R., Webb, W.W. and Keller, B.U. (2003) Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouse. J. Physiol. 547, 775–787.
Ladewig, T., Lalley, P.M. and Keller, B.U. (2004) Serotonergic modulation of intracellular calcium dynamics in neonatal hypoglossal motoneurons from mouse. Brain Res. 1001, 1–12.
Lips, M.B. and Keller, B.U. (1999) Activity-related calcium dynamics in motoneurons of the nucleus hypoglossus from mouse. J. Neurophysiol. 82, 2936–2946.
Purvis, L.K. and Butera, R.J. (2005) Ionic current model of a hypoglossal motoneuron. J. Neurophysiol. 93, 723–733.
Talley, E.M., Lei, Q., Sirois, J.E. and Bayliss, D.A. (2000) TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 25, 399–410.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Tsao, TH.B., Butera, R.J. (2008). Computational Model of TASK Channels and PKC-Pathway Dependent Serotonergic Modulatory Effects in Respiratory-Related Neurons. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_67
Download citation
DOI: https://doi.org/10.1007/978-0-387-73693-8_67
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-73692-1
Online ISBN: 978-0-387-73693-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)