Immunotherapy toward the Aβ peptide offers a unique therapeutic approach to the treatment of Alzheimer’s disease. The rationale is that antibodies interacting with the Aβ peptide will accelerate its clearance from the CNS, lead to less amyloid deposition, and reduce the other pathological features of Alzheimer’s disease. Evidence from transgenic mouse models of amyloid deposition is highly supportive of both pathological and functional benefits of this approach. Data from human trials of active immunization (using a vaccine to stimulate generation of antibodies) led to several apparent cases of autoimmune CNS inflammation.
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Morgan, D. (2007). The Rationale for an Immunological Approach to Alzheimer's Therapeutics. In: Pharmacological Mechanisms in Alzheimer's Therapeutics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71522-3_9
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