Neurogenesis occurs in the adult hippocampus and subventricular zone. It provides an exciting potential inroad to new treatments for slow neurodegenerative disorders. Changes in neurogenesis in human degenerative diseases may also teach us something about the underlying disease mechanisms. In the present chapter, we review data from clinical and experimental studies concerning neurogenesis in Alzheimer’s, Huntington’s and Parkinson’s diseases. In brief, the clinical data have not clearly shown whether the rate of neurogenesis is changed by the pathogenesis in these three diseases. Whether neurogenesis occurs at all in the adult substantia nigra under baseline conditions remains controversial. Studies on animal models of the three neurodegenerative conditions provide a mixed picture, with disease/ damage to the brain being associated both decreases and increases in neurogenesis in the different studied brain regions. In conclusion, this exciting research field is still in its infancy. It is too early to say whether neurogenesis in the adult brain can be targeted by novel therapies and be used to reduce functional deficits in slow neurodegenerative diseases.
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Deierborg, T., Li, J.Y., Brundin, P. (2007). Adult Neurogenesis in Neurodegenerative Diseases. In: Malva, J.O., Rego, A.C., Cunha, R.A., Oliveira, C.R. (eds) Interaction Between Neurons and Glia in Aging and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70830-0_20
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