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Sigma Receptors

Chemistry, Cell Biology and Clinical Implications

  • Book
  • © 2007

Overview

Editors:
  1. Tsung-Ping Su

    1. National Institute on Drug Abuse, Bethesda

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    You can also search for this editor in PubMed   Google Scholar

  2. Rae R. Matsumoto

    1. University of Mississippi, University

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    You can also search for this editor in PubMed   Google Scholar

  3. Wayne D. Bowen

    1. Brown University, Providence

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a valuable resource for those who work on sigma receptors and also as a source of comparative information for researchers on opioid and other receptors

  • Includes supplementary material: sn.pub/extras

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xi
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  2. σ Receptors: Historical Perspective and Background

    • Rae R. Matsumoto
    Pages 1-23

  3. Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands

    • Amy Hauck Newman, Andrew Coop
    Pages 25-44

  4. Irreversible σ Compounds

    • Giuseppe Ronsisvalle, Orazio Prezzavento
    Pages 45-69

  5. Pharmacophore Models for σ1 Receptor Binding

    • Seth Y. Ablordeppey, Richard A. Glennon
    Pages 71-98

  6. Cloning of σ1 Receptor and Structural Analysis of Its Gene and Promoter Region

    • Vadivel Ganapathy, Malliga E. Ganapathy, Katsuhisa lnoue
    Pages 99-112

  7. Site-Directed Mutagenesis

    • Hideko Yamamoto, Toshifumi Yamamoto, Keiko Shinohara Tanaka, Mitsunobu Yoshii, Shigeru Okuyama, Toshihide Nukada
    Pages 113-125

  8. σ Receptor Modulation of Ion Channels

    • Chris P. Palmer, Ebru Aydar, Meyer B. Jackson
    Pages 127-149

  9. Subcellular Localization and Interacellular Dynamics of σ1 Receptors

    • Teruo Hayashi, Tsung-Ping Su
    Pages 151-164

  10. Intracellular Signaling and Synaptic Plasticity

    • Francois P. Monnet
    Pages 165-193

  11. Modulation of Classical Neurotransmitter Systems by σ Receptors

    • Linda L. Werling, Alicia E. Derbez, Samer J. Nuwayhid
    Pages 195-214

  12. σ2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics

    • Wayne D. Bowen
    Pages 215-235

  13. Cognitive Effects of σ Receptor Ligands

    • Tangui Maurice
    Pages 237-271

  14. σ Receptors and Scizophrenia

    • Xavier Guitart
    Pages 273-292

  15. Potential Role of σ Ligands and Neurosteroids in Major Depression

    • Guy Debonnel, Malika Robichaud, Jordanna Bermack
    Pages 293-314

  16. σ Receptors and Drug Abuse

    • Yun Liu, Yongxin Yu, Jamaluddin Shaikh, Buddy Pouw, AnTawan Daniels, Guang-Di Chen et al.
    Pages 315-336

  17. σ1 Receptors and the Modulation of Opiate Analgesics

    • Gavril W. Pasternak
    Pages 337-350

  18. σ Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview

    • Sylvaine Galiegue, Hubert Vidal, Pierre Casellas
    Pages 351-370

  19. σ Receptors and Gastrointestinal Function

    • Francois J. Roman, Maria Chovet, Lionel Bueno
    Pages 371-391

  20. Back Matter

    Pages 393-414
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Keywords

About this book

Over the last 30 years, our understanding of a receptors has undergone a colossal evolution. They began as theoretical entities, then progressed to enigmatic receptors, and finally to identified proteins with important biological functions. Since the first book on a receptors was published in 1994, there have been many significant advances in the field. We now know that o receptors subserve many critical functions in the body and recent studies indicate that they are promising drug development targets for a host of neurological, psychiatric, cardiovascular, ophthalmological, immunological, and gastrointestinal disorders. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of a receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and it provides a launching point from which future studies and research directions can easily be developed. The full impact of a receptors on biological function has yet to be determined. The existing gaps in our knowledge base offer untold opportunities for future research. It is our hope that the information contained in this book will stimulate new, exciting research on a receptors and ultimately lead to innovative insights into basic biological mechanisms and novel therapeutic advances.

Editors and Affiliations

  • National Institute on Drug Abuse, Bethesda

    Tsung-Ping Su

  • University of Mississippi, University

    Rae R. Matsumoto

  • Brown University, Providence

    Wayne D. Bowen

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