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Learning-Induced Changes in Sensory Synaptic Transmission

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Molecular Mechanisms of Synaptogenesis

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1. Summary

It is proposed that the central nervous system undergoes plastic changes in response to peripheral stimuli and new experiences. Consequently, alterations along central signaling processing system affect subsequent responses of animals and humans to the environment. Such long-term plastic changes not only play roles in important physiological functions such as learning and memory, but also are indispensable in unwanted pathological conditions such as chronic pain, drug addiction, and mental disorders. Investigation of such long-term plasticity using different animal models helps us to understand the molecular mechanism of brain functions. Here, I review recent work in the spinal cord dorsal horn, amygdale, and anterior cingulate cortex (ACC), and discuss the injury and learning-related changes in different regions of the brain and their implications in brain functions and mental disorders.

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8. References

  1. Nestler, E.J. (2001) Nat Rev Neurosci 2, 119–128.

    Article  PubMed  CAS  Google Scholar 

  2. LeDoux, J.E. (2000) Annu Rev Neurosci 23, 155–184.

    Article  PubMed  CAS  Google Scholar 

  3. Hyman, S.E., and Malenka, R.C. (2001) Nat Rev Neurosci 2, 695–703.

    Article  PubMed  CAS  Google Scholar 

  4. Zhuo, M. (2002) Drug Discov Today 7, 259–267.

    Article  PubMed  CAS  Google Scholar 

  5. Zhuo, M. (2005) Can J Neurol Sci 32, 27–36.

    PubMed  Google Scholar 

  6. Robinson, D.A., Calejesan, A.A., Wei, F., Gebhart, G.F., and Zhuo, M. (2004) Curr Neurovas Res 1, 11–20.

    Article  CAS  Google Scholar 

  7. Li, P., Kerchner, G.A., Sala, C., Wei, F., Huettner, J.E., Sheng, M., and Zhuo, M. (1999) Nat Neurosci 2, 972–977.

    Article  PubMed  CAS  Google Scholar 

  8. Wang, G.D., and Zhuo, M. (2002) J Neurophysiol 87, 732–739.

    PubMed  CAS  Google Scholar 

  9. Willis, W.D. (2002) Brain Res Brain Res Rev 40, 202–214.

    Article  PubMed  Google Scholar 

  10. Ikeda, H., Heinke, B., Ruscheweyh, R., and Sandkuhler, J. (2003) Science 299, 1237–1240.

    Article  PubMed  CAS  Google Scholar 

  11. Medina, J.F., Christopher Repa, J., Mauk, M.D., and LeDoux, J.E. (2002) Nat Rev Neurosci 3, 122–131.

    Article  PubMed  CAS  Google Scholar 

  12. Maren, S. (2001) Annu Rev Neurosci 24, 897–931.

    Article  PubMed  CAS  Google Scholar 

  13. Davis, M. (1992) Annu Rev Neurosci 15, 353–375.

    Article  PubMed  CAS  Google Scholar 

  14. LaBar, K.S., Gatenby, J.C., Gore, J.C., LeDoux, J.E., and Phelps, E.A. (1998) Neuron 20, 937–945.

    Article  PubMed  CAS  Google Scholar 

  15. Phelps, E.A., O’Connor, K.J., Gatenby, J.C., Gore, J.C., Grillon, C., and Davis, M. (2001) Nat Neurosci 4, 437–441.

    Article  PubMed  CAS  Google Scholar 

  16. Anderson, A.K., and Phelps, E.A. (2001) Nature 411, 305–309.

    Article  PubMed  CAS  Google Scholar 

  17. Romanski, L.M., and LeDoux, J.E. (1993) Cereb Cortex 3, 515–532.

    PubMed  CAS  Google Scholar 

  18. Maren, S., Aharonov, G., and Fanselow, M.S. (1997) Behav Brain Res 88, 261–274.

    Article  PubMed  CAS  Google Scholar 

  19. Rudy, J.W., Barrientos, R.M., and O’Reilly, R.C. (2002) Behav Neurosci 116, 530–538.

    Article  PubMed  Google Scholar 

  20. Turner, B.H., and Zimmer, J. (1984) J Comp Neurol 227, 540–557.

    Article  PubMed  CAS  Google Scholar 

  21. McDonald, A.J. (1998) Prog Neurobiol 55, 257–332.

    Article  PubMed  CAS  Google Scholar 

  22. Rogan, M.T., and LeDoux, J.E. (1995) Neuron 15, 127–136.

    Article  PubMed  CAS  Google Scholar 

  23. Huang, Y.Y., and Kandel, E.R. (1998) Neuron 21, 169–178.

    Article  PubMed  CAS  Google Scholar 

  24. Weisskopf, M.G., and LeDoux, J.E. (1999) J Neurophysiol 81, 930–934.

    PubMed  CAS  Google Scholar 

  25. McKernan, M.G., and Shinnick-Gallagher, P. (1997) Nature 390, 607–611.

    Article  PubMed  CAS  Google Scholar 

  26. Rogan, M.T., Staubli, U.V., and LeDoux, J.E. (1997) Nature 390, 604–607.

    Article  PubMed  CAS  Google Scholar 

  27. Miserendino, M.J., Sananes, C.B., Melia, K.R., and Davis, M. (1990) Nature 345, 716–718.

    Article  PubMed  CAS  Google Scholar 

  28. Schafe, G.E., Atkins, C.M., Swank, M.W., Bauer, E.P., Sweatt, J.D., and LeDoux, J.E. (2000) J Neurosci 20, 8177–8187.

    PubMed  CAS  Google Scholar 

  29. Schafe, G.E., and LeDoux, J.E. (2000) J Neurosci 20, RC96.

    PubMed  CAS  Google Scholar 

  30. Tsvetkov, E., Carlezon, W.A., Benes, F.M., Kandel, E.R., and Bolshakov, V.Y. (2002) Neuron 34, 289–300.

    Article  PubMed  CAS  Google Scholar 

  31. Rodrigues, S.M., Schafe, G.E., and LeDoux, J.E. (2004) Neuron 44, 75–91.

    Article  PubMed  CAS  Google Scholar 

  32. Rodrigues, S.M., Schafe, G.E., and LeDoux, J.E. (2001) J Neurosci 21, 6889–6896.

    PubMed  CAS  Google Scholar 

  33. Bauer, E.P., Schafe, G.E., and LeDoux, J.E. (2002) J Neurosci 22, 5239–5249.

    PubMed  CAS  Google Scholar 

  34. Wei, F., Qiu, C.S., Liauw, J., Robinson, D.A., Ho, N., Chatila, T., and Zhuo, M. (2002) Nat Neurosci 5, 573–579.

    Article  PubMed  CAS  Google Scholar 

  35. Schafe, G.E., Bauer, E.P., Rosis, S., Farb, C.R., Rodrigues, S.M., and LeDoux, J.E. (2005) Eur J Neurosci 22, 201–211.

    Article  PubMed  Google Scholar 

  36. Faber, E.S., Delaney, A.J., and Sah, P. (2005) Nat Neurosci 8, 635–641.

    Article  PubMed  CAS  Google Scholar 

  37. Huang, Y.Y., Martin, K.C., and Kandel, E.R. (2000) J Neurosci 20, 6317–6325.

    PubMed  CAS  Google Scholar 

  38. Rumpel, S., Ledoux, J., Zador, A., and Malinow, R. (2005) Science 308, 83–99.

    Article  PubMed  CAS  Google Scholar 

  39. Ko, S., Zhao, M.G., Toyoda, H., Qiu, C.S., and Zhuo, M. (2005) J Neurosci 25, 977–984.

    Article  PubMed  CAS  Google Scholar 

  40. Wu, L.J., Zhao, M.G., Toyoda, H., Ko, S.W., and Zhuo, M. (2005) J Neurophysiol 94, 1805–1813.

    Article  PubMed  CAS  Google Scholar 

  41. Liauw, J., Wang, G.D., and Zhuo, M. (2003) Sheng Li Xue Bao 55, 373–380.

    PubMed  CAS  Google Scholar 

  42. Tang, J., Ko, S., Ding, H.K., Qiu, C.S., Calejesan, A.A., and Zhuo, M. (2005) Mol Pain 1, 6.

    Article  PubMed  Google Scholar 

  43. Zhao, M.G., Toyoda, H., Lee, Y.S., Wu, L.J., Ko, S.W., Zhang, X.H., Jia, Y., Shum, F., Xu, H., Li, B.M., Kaang, B.K., and Zhuo, M. (2005) Neuron 47, 859–872.

    Article  PubMed  CAS  Google Scholar 

  44. Frankland, P.W., Bontempi, B., Talton, L.E., Kaczmarek, L., and Silva, A.J. (2004) Science 304, 881–883.

    Article  PubMed  CAS  Google Scholar 

  45. Tang, Y.P., Shimizu, E., Dube, G.R., Rampon, C., Kerchner, G.A., Zhuo, M., Liu, G., and Tsien, J.Z. (1999) Nature 401, 63–69.

    Article  PubMed  CAS  Google Scholar 

  46. Wei, F., Wang, G.D., Kerchner, G.A., Kim, S.J., Xu, H.M., Chen, Z.F., and Zhuo, M. (2001) Nat Neurosci 4, 164–169.

    Article  PubMed  CAS  Google Scholar 

  47. Wei, F., Qiu, C.S., Kim, S.J., Muglia, L., Maas, J.W., Pineda, V.V., Xu, H.M., Chen, Z.F., Storm, D.R., Muglia, L.J., and Zhuo, M. (2002) Neuron 36, 713–726.

    Article  PubMed  CAS  Google Scholar 

  48. Tao, Y.X., Rumbaugh, G., Wang, G.D., Petralia, R.S., Zhao, C., Kauer, F.W., Tao, F., Zhuo, M., Wenthold, R.J., Raja, S.N., Huganir, R.L., Bredt, D.S., and Johns, R.A. (2003) J Neurosci 23, 6703–6712.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, Ontario, Canada, M5S 1A8

    Min Zhuo

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  1. Min Zhuo
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Editor information

Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Zhuo, M. (2006). Learning-Induced Changes in Sensory Synaptic Transmission. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_26

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