Abstract
Acute interstitial nephritis (AIN) may be the result of indirect injury by drugs, reaction to systemic infections, direct renal infection (viral and selected bacteria), humoral immune responses (anti-tubular basement membrane disease), hereditary and metabolic disorders, and obstruction and reflux in the acute stages. Similar changes can also be observed in the kidney in systemic diseases such as lupus erythematosus and in transplant rejection. Acute tubulointerstitial nephritis also occurs to varying degrees in association with glomerulonephritides. This section is largely confined to the drug-induced, reactive, idiopathic and immunologic disorders inducing AIN. Acute interstitial nephritis usually presents with acute renal failure, often oliguric; it is sometimes associated with systemic manifestations such as arthralgia fever, eosinophilia and rash, typically as a consequence of drug hypersensitivity (1–3).
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References
Rastegar A, Kashgarian M. The clinical-spectrum of tubulo-interstitial nephritis. Kidney Int 54:313–327, 1998.
Michel DM, Kelly CJ. Acute interstitial nephritis. J Am Soc Nephrol 9:506–515, 1998.
Cavallo T. Tubulo-interstitial nephritis. In: Jennette JC, Olson JL, Schwartz MM, Silva FG, eds. Heptinstall’s Pathology of the Kidney, 5th ed. Philadelphia: Lippincott-Raven, 1998:667–724.
Clarkson MR, Giblin L, O’Connell FP, et al. Acute interstitial nephritis: clinical features and response to corticosteroid therapy. Nephrol Dial Transplant 19:2778–2783, 2004.
Markowitz GS, Perazella MA. Drug-induced renal failure: a focus on tubuloin-terstitial disease. Clin Chim Acta 351:31–47, 2005.
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Cohen, A.H. (2006). Acute Interstitial Nephritis. In: Fogo, A.B., Cohen, A.H., Jennette, J.C., Bruijn, J.A., Colvin, R.B. (eds) Fundamentals of Renal Pathology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-31127-2_13
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DOI: https://doi.org/10.1007/978-0-387-31127-2_13
Publisher Name: Springer, New York, NY
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