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Pasteurella multocida: Diseases and Pathogenesis

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Book cover Pasteurella multocida

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 361))

Abstract

Pasteurella multocida is an enigmatic pathogen. It is remarkable both for the number and range of specific disease syndromes with which it is associated, and the wide range of host species affected. The pathogenic mechanisms involved in causing the different syndromes are, for the most part, poorly understood or completely unknown. The biochemical and serological properties of some organisms responsible for quite different syndromes appear to be similar. Thus, the molecular basis for host predilection remains unknown. The recent development of genetic manipulation systems together with the availability of multiple genome sequences should help to explain the association of particular pathological conditions with particular hosts as well as helping to elucidate pathogenic mechanisms.

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References

  • Ackermann MR, Cheville NF, Gallager JE (1991) Colonization of the pharyngeal tonsil and respiratory tract of the gnotobiotic pig by a toxigenic strain of Pasteurella multocida type D. Vet Pathol 28:267

    Article  PubMed  CAS  Google Scholar 

  • Al-haj Ali H, Sawada T, Hatakeyama H, Katayama Y, Ohtsuki N, Itoh O (2004) Invasion of chicken embryo fibroblast cells by avian Pasteurella multocida. Vet Microbiol 104:55–62

    Article  PubMed  CAS  Google Scholar 

  • Aye PP, Angerick EJ, Morishita TY, Harr BS (2001) Prevalence and characteristics of Pasteurella multocida in commercial turkeys. Avian Dis 45:182–190

    Article  PubMed  CAS  Google Scholar 

  • Baalsrud KJ (1987) Atrophic rhinitis in goats in Norway. Vet Rec 121:350–353

    Article  PubMed  CAS  Google Scholar 

  • Backstrand JM, Botzler RG (1986) Survival of Pasteurella multocida in soil and water in an area where avian cholera is enzootic. J Wildl Dis 22:257–259

    Article  PubMed  CAS  Google Scholar 

  • Baillot R, Voisine P, Côté L, Longtin Y (2011) Deep sternal wound infection due to Pasteurella multocida: the first case report and review of literature. Infection 39:575–578

    Article  PubMed  CAS  Google Scholar 

  • Berndt A, Heller M, Kosmehl H (2002) Cytokine mRNA expression in experimental porcine pneumonia. Deutsche Tierarzt Wochenschr 109:205–209

    CAS  Google Scholar 

  • Bethe A, Weiler LH, Selbitz H-J, Ewers C (2009) Genetic diversity of porcine Pasteurella multocida strains from the respiratory tracts of healthy and diseased swine. Vet Microbiol 139:97–105

    Article  PubMed  CAS  Google Scholar 

  • Bojesen A, Petersen K, Nielsen O, Christensen J, Bisgaard M (2004) Pasteurella multocida infection in heterophil-depleted chickens. Avian Dis 48:463–470

    Article  PubMed  Google Scholar 

  • Bosch M, Garrido E, Llagostera M, Perez de Rozas AM, Badiola I, Barbe J (2002a) Pasteurella multocida exbB, exbD and tonB genes are physically linked but independently transcribed. FEMS Microbiol Lett 210:201–208

    Article  PubMed  CAS  Google Scholar 

  • Bosch M, Garrido ME, Llagostera M, Perez de Rozas AM, Badiola I, Barbe J (2002b) Characterization of the Pasteurella multocida hgbA gene encoding a hemoglobin-binding protein. Infect Immun 70:5955–5964

    Article  PubMed  CAS  Google Scholar 

  • Bosch M, Garrido ME, Perez de Rozas AM, Badiola I, Barbe J, Llagostera M (2004) Pasteurella multocida contains multiple immunogenic haemin- and haemoglobin-binding proteins. Vet Microbiol 99:103–112

    Article  PubMed  CAS  Google Scholar 

  • Bowles RE, Pahoff JL, Smith BN, Blackall PJ (2000) Ribotype diversity of porcine Pasteurella multocida from Australia. Aust Vet J 78:630–635

    Article  PubMed  CAS  Google Scholar 

  • Boyce JD, Adler B (2000) The capsule is a virulence determinant in the pathogenesis of Pasteurella multocida M1404 (B:2). Infect Immun 68:3463–3468

    Article  PubMed  CAS  Google Scholar 

  • Boyce JD, Adler B (2006) How does Pasteurella multocida respond to the host environment? Curr Opin Microbiol 9:117–122

    Article  PubMed  CAS  Google Scholar 

  • Boyce JD, Wilkie I, Harper M, Paustian M, Kapur V, Adler B (2002) Genome scale analysis of Pasteurella multocida gene expression during growth within the natural chicken host. Infect Immun 70:6871–6879

    Article  PubMed  CAS  Google Scholar 

  • Boyce JD, Harper M, St Michael F, John M, Aubry A, Parnas H, Logan SM, Wilkie IW, Ford M, Cox AD, Adler B (2009) Identification of novel glycosyltransferases required for assembly of the Pasteurella multocida A:1 lipopolysaccharide and their involvement in virulence. Infect Immun 77:1532–1542

    Article  PubMed  CAS  Google Scholar 

  • Boyce JD, Harper M, Wilkie I, Adler B (2010) Pasteurella. In: Gyles CL, Prescott JF, Songer JG, Thoen CO (eds) Pathogenesis of bacterial infections in animals. Blackwell Publishing, Iowa

    Google Scholar 

  • Cameron RDA, O’Boyle D, Frost AJ, Gordon AN, Fegan N (1996) An outbreak of haemorrhagic septicaemia associated with Pasteurella multocida subsp gallicida in a large pig herd. Aust Vet J 73:27–29

    Article  PubMed  CAS  Google Scholar 

  • Catry B, Chiers K, Schwarz S, Kehrenberg C, Decostere A, de Kruif A (2005) Fatal peritonitis caused by Pasteurella multocida capsular Type F in calves. J Clin Microbiol 43:1480–1483

    Article  PubMed  Google Scholar 

  • Chang K, Siu LK, Chen Y-H, Lu P-L, Chen T-C, Hsieh H-C, Lin C-L (2007) Fatal Pasteurella multocida septicemia and necrotizing fasciitis related with wound licked by a domestic dog. Scand J Infect Dis 39:167–170

    Article  PubMed  CAS  Google Scholar 

  • Chung JY, Wilkie I, Boyce JD, Townsend KM, Frost AJ, Ghoddusi M, Adler B (2001) Role of capsule in the pathogenesis of fowl cholera caused by Pasteurella multocida serogroup A. Infect Immun 69:2487–2493

    Article  PubMed  CAS  Google Scholar 

  • Ciprian A, Pijoan C, Cruz T, Camacho J, Tortora J, Colmenares G, Lopez-Revilla R, de la Garza M (1988) Mycoplasma hyopneumoniae increases the susceptibility of pigs to experimental Pasteurella multocida pneumonia. Can J Vet Res 52:434–438

    PubMed  CAS  Google Scholar 

  • Collins FM, Niederbuhl CJ, Campbell SG (1983) Bactericidal activity of alveolar and peritoneal macrophages exposed in vitro to three strains of Pasteurella multocida. Infect Immun 39:779–784

    PubMed  CAS  Google Scholar 

  • Confer AW (2009) Update on bacterial pathogenesis in BRD. Anim Health Res Rev 10:145–148

    Article  PubMed  Google Scholar 

  • Cox AJ, Hunt ML, Boyce JD, Adler B (2003) Functional characterization of HgbB, a new hemoglobin binding protein of Pasteurella multocida. Microb Pathog 34:287–296

    Article  PubMed  CAS  Google Scholar 

  • Curtis PE, Ollerhead GE (1981) Investigation to determine whether healthy chickens and turkeys are oral carriers of Pasteurella multocida. Vet Rec 108:206–207

    Article  PubMed  CAS  Google Scholar 

  • Dabo S, Confer A, Quijano-Blas R (2003) Molecular and immunological characterization of Pasteurella multocida serotype A:3 OmpA: evidence of its role in P. multocida interaction with extracellular matrix molecules. Microb Pathog 35:147–157

    Article  PubMed  CAS  Google Scholar 

  • Dabo SM, Confer AW, Hartson SD (2005) Adherence of Pasteurella multocida to fibronectin. Vet Microbiol 110:265–275

    Article  PubMed  CAS  Google Scholar 

  • Dabo SM, Taylor JD, Confer AW (2008) Pasteurella multocida and bovine respiratory disease. Anim Health Res Rev 8:129–150

    Article  Google Scholar 

  • De Alwis MCL (1999) ACIAR monograph 57: haemorrhagic septicaemia. Australian Centre for International Agricultural Research, Canberra

    Google Scholar 

  • De Alwis MCL, Vipulasiri AA (1980) An epizootiological study of haemorrhagic septicaemia in Sri Lanka. Ceylon Vet J 28:24–35

    Google Scholar 

  • De Alwis MCL, Wijewardana TG, Sivaram A, Vipulasiri AA (1986) The carrier and antibody status of cattle and buffaloes exposed to haemorrhagic septicaemia: investigations on survivors following natural outbreaks. Sri Lankan Vet J 34:33–42

    Google Scholar 

  • Deeb BJ, DiGiacomo RF, Bernard BL, Silbernagel SM (1990) Pasteurella multocida and Bordetella bronchiseptica infections in rabbits. J Clin Microbiol 28:70–75

    PubMed  CAS  Google Scholar 

  • Derieux WT (1978) Response of young chickens and turkeys to virulent and avirulent Pasteurella multocida administered by various routes. Avian Dis 22:131–139

    Article  PubMed  CAS  Google Scholar 

  • Despande MS, Ambagala TC, Ambagala APN, Kehrli ME, Srikumaran S (2002) Bovine CD18 is necessary and sufficient to mediate Mannheimia (Pasteurella) haemolytica leukotoxin-induced cytolysis. Infect Immun 70:5058–5064

    Article  Google Scholar 

  • DiGiacomo RF, Deeb BJ, Giddens WE, Bernard BL, Chengappa MM (1989) Atrophic rhinitis in New Zealand white rabbits infected with Pasteurella multocida. Am J Vet Res 50:1460–1465

    PubMed  CAS  Google Scholar 

  • DiGiacomo RF, Xu YM, Allen V, Hunter MH, Pearson GR (1991) Naturally-acquired Pasteurella multocida infection in rabbits: clinicopathological aspects. Can J Vet Res 55:234–238

    PubMed  CAS  Google Scholar 

  • Dillehay DL, Paul KS, DiGiacomo RF, Chengappa MM (1991) Pathogenicity of Pasteurella multocida A3 in Flemish Giant and New Zealand White rabbits. Lab Anim Sci 25:337–341

    Article  CAS  Google Scholar 

  • Dominick MA, Rimler RB (1988) Turbinate osteoporosis in pigs following intranasal inoculation of purified Pasteurella toxin: histomorphometric and ultrastructural studies. Vet Pathol 25:17–27

    Article  PubMed  CAS  Google Scholar 

  • Dowling AJ, Hodgson C, Schock A, Donachie W, Ekersall PD, McKendrick IJ (2002) Experimental induction of pneumonic pasteurellosis in calves by intratracheal infection with Pasteurella multocida biotype A:3. Res Vet Sci 73:37–44

    Article  PubMed  CAS  Google Scholar 

  • Eliás B, Boros G, Albert M, Tuboly S, Gergely P, Papp L, Barna Vetró I, Rafai P, Molnár E (1990) Clinical and pathological effects of the dermonecrotic toxin of Bordetella bronchiseptica and Pasteurella multocida in specific-pathogen-free piglets. Nihon Juigaku Zasshi 52:677–688

    Article  PubMed  Google Scholar 

  • Ewers C, Lubke-Becker A, Bethe A, Kiebling S, Filter M, Wieler LH (2006) Virulence genotype of Pasteurella multocida strains isolated from different hosts with various disease status. Vet Microbiol 114:304–317

    Article  PubMed  CAS  Google Scholar 

  • Freshwater A (2008) Why your housecat’s trite little bite could cause you quite a fright: a study of domestic felines on the occurrence and antibiotic susceptibility of Pasteurella multocida. Zoonoses Public Health 55:507–513

    Article  PubMed  CAS  Google Scholar 

  • Fuller TE, Kennedy MJ, Lowery DE (2000) Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis. Microb Pathog 29:25–38

    Article  PubMed  CAS  Google Scholar 

  • Fulton RW (2009) Bovine respiratory disease research (1983–2009). Anim Health Res Rev 10:131–139

    Article  PubMed  Google Scholar 

  • Galdiero M, De Martino L, Pagnini U, Pisciotta M-G, Galdiero E (2001) Interactions between bovine endothelial cells and Pasteurella multocida: association and invasion. Res Microbiol 152:57–65

    Article  PubMed  CAS  Google Scholar 

  • Glass SE, Panigrahy B (1990) Dermal necrosis caused by Pasteurella multocida infection in turkeys. Avian Dis 34:491–494

    Article  PubMed  CAS  Google Scholar 

  • Hall WF, Bane DP, Kilroy CR, Essex-Sorlie DL (1990) A model for the induction of Pasteurella multocida type-A pneumonia in pigs. Can J Vet Res 54:238–243

    PubMed  CAS  Google Scholar 

  • Hamilton TDC, Roe JM, Hayes CM, Webster AJF (1998) Effect of ammonia inhalation and acetic acid pretreatment on colonisation kinetics of toxigenic Pasteurella multocida within the upper respiratory tract of swine. J Clin Microbiol 36:1260–1265

    PubMed  CAS  Google Scholar 

  • Hansen MS, Pors SE, Jensen HE, Bille-Jensen V, Bisgaard M, Flachs EM, Nielsen OL (2010) An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J Comp Path 143:120–131

    Article  PubMed  CAS  Google Scholar 

  • Harel J, Cote S, Jacques M (1990) Restriction endonuclease analysis of porcine Pasteurella multocida isolates from Quebec. Can J Vet Res 54:422–426

    PubMed  CAS  Google Scholar 

  • Harmon BG, Glisson JR, Nunnally JC (1992) Turkey macrophage and heterophil bactericidal activity against Pasteurella multocida. Avian Dis 36:989–991

    Google Scholar 

  • Harper M, Boyce JD, Wilkie IW, Adler B (2003) Signature-tagged mutagenesis of Pasteurella multocida identifies mutants displaying differential virulence characteristics in mice and chickens. Infect Immun 71:5440–5446

    Article  PubMed  CAS  Google Scholar 

  • Harper M, Boyce JD, Adler B (2006) Pasteurella multocida pathogenesis: 125 years after Pasteur. FEMS Microbiol Lett 265:1–10

    Article  PubMed  CAS  Google Scholar 

  • Hassanin HH, Toth TE, Eldimerdash M, Siegel PB (1995) Stimulation of avian respiratory phagocytes by Pasteurella multocida––effects of the route of exposure, bacterial dosage and strain, and the age of chickens. Vet Microbiol 46:401–413

    Article  PubMed  CAS  Google Scholar 

  • Hindman LJ, Harvey WF, Costanzo GR, Converse KA, Stein G (1997) Avian cholera in ospreys: first occurrence and possible mode of transmission. J Field Ornithol 68:503–508

    Google Scholar 

  • Horadagoda NU, Hodgson JC, Moon GM, Wijewardana TG, Eckersall PD (2001) Role of endotoxin in the pathogenesis of haemorrhagic septicaemia in the buffalo. Microb Pathog 30:171–178

    Article  PubMed  CAS  Google Scholar 

  • Hundt MJ, Ruffolo CG (2005) Interaction of Pasteurella multocida with free-living amoebae. Appl Environ Microbiol 71:5458–5464

    Article  PubMed  CAS  Google Scholar 

  • Hunter B, Wobeser G (1980) Pathology of experimental avian cholera in mallard ducks. Avian Dis 24:403–414

    Article  PubMed  CAS  Google Scholar 

  • Jordan RW, Roe JM (2004) An experimental mouse model of progressive atrophic rhinitis of swine. Vet Microbiol 103:201–207

    Article  PubMed  CAS  Google Scholar 

  • Jubb KV, Maxie MG (2007) Pathology of domestic animals, 5th edn. Elsevier Saunders, New York

    Google Scholar 

  • Kachlany SC, Planet PJ, DeSalle R, Fine DH, Figurski DH, Kaplan JB (2001) flp-1, the first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans. Mol Microbiol 40:542–554

    Article  PubMed  CAS  Google Scholar 

  • Kaden V, Teifke JP, Polster V (2001) Progressive atrophic rhinitis––a rare disease in wild boar. Zeitschr Jagdenwissensch 47:17–25

    Google Scholar 

  • Lee MD, Wooley RE, Glisson JR (1994) Invasion of epithelial cell monolayers by turkey strains of Pasteurella multocida. Avian Dis 38:72–77

    Article  PubMed  CAS  Google Scholar 

  • Mackie JT, Barton M, Kettlewell J (1992) Pasteurella multocida septicaemia in pigs. Aust Vet J 69:227–228

    Article  PubMed  CAS  Google Scholar 

  • Martineau-Doize B, Dumas G, Larochelle R, Frantz JC, Martineau G-P (1991) Atrophic rhinitis caused by Pasteurella multocida type D: morphometric analysis. Can J Vet Res 55:224–228

    PubMed  CAS  Google Scholar 

  • Matsumoto M, Strain JG, Engel HN (1991) The fate of Pasteurella multocida after intratracheal inoculation into turkeys. Poult Sci 70:2259–2266

    Article  PubMed  CAS  Google Scholar 

  • May BJ, Zhang Q, Li LL, Paustian ML, Whittam TS, Kapur V (2001) Complete genomic sequence of Pasteurella multocida, Pm70. Proc Natl Acad Sci USA 98:3460–3465

    Article  PubMed  CAS  Google Scholar 

  • Mbuthia PG, Njagi LW, Nyaga PN, Bebora LC, Minga U, Kamundia J, Olsen JE (2008) Pasteurella multocida in scavenging family chickens and ducks: carrier status, age susceptibility and transmission between species. Avian Pathol 37:51–57

    Article  PubMed  CAS  Google Scholar 

  • McFadden MJ, Christensen H, Fairley AR, Hill FI, Gill JM, Keeling SE, Spence RP (2011) Outbreaks of pleuritis and peritonitis in calves associated with Pasteurella multocida capsular type B strain. N Z Vet J 59:40–45

    Article  PubMed  CAS  Google Scholar 

  • Morrison RB, Hilley HD, Leman AD (1985) The association between pneumonia and atrophic rhinitis in slaughter weight swine. Can Vet J 26:95–97

    PubMed  CAS  Google Scholar 

  • Morton DJ, Whitby PW, Jin H, Ren Z, Stull TL (1999) Effect of multiple mutations in the hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b. Infect Immun 67:2729–2739

    PubMed  CAS  Google Scholar 

  • Muhairwa AP, Christensen JP, Bisgaaard M (2000) Investigations on the carrier rate of Pasteurella multocida in healthy commercial poultry flocks and flocks affected by fowl cholera. Avian Pathol 29:133–142

    Article  PubMed  CAS  Google Scholar 

  • Mullan PB, Lax AJ (1998) Pasteurella multocida toxin stimulates bone resorption by osteoclasts via interaction with osteoblasts. Calcif Tiss Int 63:340–345

    Article  CAS  Google Scholar 

  • Mullen LM, Bossé JT, Nair SP, Ward JM, Rycroft AN, Robertson G, Langford PR, Henderson B (2008a) Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins. PLoS ONE 3:e3991

    Article  PubMed  CAS  Google Scholar 

  • Mullen LM, Nair SP, Ward JM, Rycroft AN, Williams RJ, Robertson G, Mordan NJ, Henderson B (2008b) Novel adhesin from Pasteurella multocida that binds to the integrin-binding fibronectin FnIII9-10 repeats. Infect Immun 76:1093–1104

    Article  PubMed  CAS  Google Scholar 

  • Muller G, Kohler H (1997) Experimental affecting of pulmonary clearance of Pasteurella multocida induced pneumonia in swine. Berliner Munchener Tierarztl Wochenschr 110:378–380

    CAS  Google Scholar 

  • Ogunnariwo JA, Schryvers AB (2001) Characterization of a novel transferrin receptor in bovine strains of Pasteurella multocida. J Bacteriol 183:890–1084

    Article  PubMed  CAS  Google Scholar 

  • Pabs-Garnon LF, Soltys MA (1971) Methods of transmission of fowl cholera in turkeys. Am J Vet Res 32:1119–1120

    PubMed  CAS  Google Scholar 

  • Paisley LG, Vraa-Andersen L, Dybkjaer L, Møller K, Christensen G, Mousing J, Agger JF (1993) An epidemiologic and economic study of respiratory diseases in two conventional Danish swine herds. II: associations between lesions present at slaughter and mean daily gains during specific intervals of the growth period. Acta Vet Scand 34:331–344

    PubMed  CAS  Google Scholar 

  • Paustian ML, May BJ, Kapur V (2001) Pasteurella multocida gene expression in response to iron limitation. Infect Immun 69:4109–4115

    Article  PubMed  CAS  Google Scholar 

  • Paustian ML, May BJ, Cao D, Boley D, Kapur V (2002) Transcriptional response of Pasteurella multocida to defined iron sources. J Bacteriol 184:6714–6720

    Article  PubMed  CAS  Google Scholar 

  • Pelicic V (2008) Type IV pili: e pluribus unum? Mol Microbiol 68:827–837

    Article  PubMed  CAS  Google Scholar 

  • Petersen KD, Christensen JP, Permin A, Bisgard M (2001) Virulence of Pasteurella multocida subsp multocida isolated from outbreaks of avian cholera in wild birds for domestic poultry and game birds. Avian Pathol 30:27–31

    Article  PubMed  CAS  Google Scholar 

  • Pijoan C, Trigo F (1990) Bacterial adhesion to mucosal surfaces with special reference to Pasteurella multocida isolates from atrophic rhinitis. Can J Vet Res 54(Suppl):S16–S21

    PubMed  Google Scholar 

  • Poermadjaja B, Frost A (2000) Phagocytic uptake and killing of virulent and avirulent strains of Pasteurella multocida of capsular serotype A by chicken macrophages. Vet Microbiol 72:163–171

    Article  PubMed  CAS  Google Scholar 

  • Pruimboom IM, Rimler RB, Ackermann MR (1999) Enhanced adhesion of Pasteurella multocida to cultured turkey peripheral blood monocytes. Infect Immun 67:1292–1296

    PubMed  CAS  Google Scholar 

  • Purdy CW, Straus DC, Chirase N, Ayers JR, Hoover MD (2003) Effects of aerosolized dust in goats on lung clearance of Pasteurella and Mannheimia species. Curr Microbiol 46:174–179

    Article  PubMed  CAS  Google Scholar 

  • Rad MA, Movassaghi R, Sharifi K, Naseri Z, Seifi HA (2011) Two outbreaks of Pasteurella multocida septicaemia in neonatal lambs. Comp Clin Pathol 20:57–59

    Article  Google Scholar 

  • Ramdani (1992) Studies on pathogenesis and immunochemistry of Pasteurella multocida model infection in mice. PhD thesis, Monash University, Melbourne

    Google Scholar 

  • Rhoades KR, Rimler RB (1990) Pasteurella multocida colonization and invasion in experimentally exposed turkey poults. Avian Dis 34:381–383

    Article  PubMed  CAS  Google Scholar 

  • Ross RF (2006) Pasteurella multocida and its role in porcine pneumonia. Anim Health Res Rev 7:13–29

    Article  PubMed  Google Scholar 

  • Rouman MP, Van de Goor PT (1988) Atrophic rhinitis in cattle. Tijdschr Diergeneesk 113:28

    Google Scholar 

  • Ruffolo CG, Tennent JM, Michalski WP, Adler B (1997) Identification, purification, and characterization of the type 4 fimbriae of Pasteurella multocida. Infect Immun 65:339–343

    PubMed  CAS  Google Scholar 

  • Saif YM (2008) Diseases of poultry. Wiley-Blackwell, Ames

    Google Scholar 

  • Scheidt A, Mayrose VB, Hill MA, Clark LK, Cline TR, Knox KE, Runnels LJ, Frantz S, Einstein ME (1990) Relationship of growth performance to pneumonia and atrophic rhinitis detected in pigs at slaughter. J Am Vet Med Assoc 196:881–884

    PubMed  CAS  Google Scholar 

  • Sheikh MA, Yaqoob T, Baig MS, Mahamood AM, Shakoori AR (1994) The epidemiology of haemorrhagic septicaemia of buffaloes in Pakistan. Buffalo J 10:229–236

    Google Scholar 

  • Talan DA, Citron DM, Abrahamian FM, Moran GJ, Goldstein EJC (1999) Bacteriologic analysis of infected dog and cat bites. New Eng J Med 340:85–92

    Article  PubMed  CAS  Google Scholar 

  • Tatum F, Yersin A, Briggs R (2005) Construction and virulence of a Pasteurella multocida fhaB2 mutant in turkeys. Microb Pathog 39:9–17

    Article  PubMed  CAS  Google Scholar 

  • Tatum FM, Tabatabai LB, Briggs RE (2009) Sialic acid uptake is necessary for virulence of Pasteurella multocida in turkeys. Microb Pathog 46:337–344

    Article  PubMed  CAS  Google Scholar 

  • Tennent JM, Mattick JS (1994) Type 4 fimbriae. In: Klemm P (ed) Fimbriae: adhesion, genetics, biogenesis and vaccines. CRC Press Inc., Boca Raton

    Google Scholar 

  • Tsuji M, Matsumoto M (1990) Immune defence mechanism against blood-borne Pasteurella multocida in turkeys. Res Vet Sci 48:344–349

    PubMed  CAS  Google Scholar 

  • Wassenaar TM, Gaastra W (2001) Bacterial virulence: can we draw the line? FEMS Microbiol Lett 201:1–7

    Article  PubMed  CAS  Google Scholar 

  • Watson PJ, Davies RL (2002) Outbreak of Pasteurella multocida septicaemia in neonatal lambs. Vet Rec 151:420–422

    Article  PubMed  CAS  Google Scholar 

  • Wilkie IW, Grimes SE, O’Boyle D, Frost AJ (2000) The virulence and protective efficacy for chickens of Pasteurella multocida administered by different routes. Vet Microbiol 72:157–168

    Google Scholar 

  • Williams ES, Runde DE, Mills K, Holler LD (1987) Avian cholera in a gyrfalcon (Falco rusticolus). Avian Dis 31:380–382

    Article  PubMed  CAS  Google Scholar 

  • Zhao G, Pijoan C, Murtaugh MP (1993) Epidemiology of Pasteurella multocida in a farrow to finish swine herd. Can J Vet Res 57:136–138

    PubMed  CAS  Google Scholar 

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Acknowledgments

Original work in the author’s laboratories was supported by the Australian Research Council, the Australian Centre for International Agricultural Research, and the Australian Poultry Co-operative Research Centre.

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Wilkie, I.W., Harper, M., Boyce, J.D., Adler, B. (2012). Pasteurella multocida: Diseases and Pathogenesis. In: Aktories, K., Orth, J., Adler, B. (eds) Pasteurella multocida. Current Topics in Microbiology and Immunology, vol 361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_216

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