Abstract
Extinguishing fear and defensive responses to environmental threats when they are no longer warranted is a critical learning ability that can promote healthy self-regulation and, ultimately, reduce susceptibility to or maintenance of affective-, trauma-, stressor-,and anxiety-related disorders. Neuroimaging tools provide an important means to uncover the neural mechanisms of effective extinction learning that, in turn, can abate the return of fear. Here I review the promises and pitfalls of functional neuroimaging as a method to investigate fear extinction circuitry in the healthy human brain. I discuss the extent to which neuroimaging has validated the core circuits implicated in rodent models and has expanded the scope of the brain regions implicated in extinction processes. Finally, I present new advances made possible by multivariate data analysis tools that yield more refined insights into the brain–behavior relationships involved.
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LaBar, K.S. (2023). Neuroimaging of Fear Extinction. In: Milad, M.R., Norrholm, S.D. (eds) Fear Extinction. Current Topics in Behavioral Neurosciences, vol 64. Springer, Cham. https://doi.org/10.1007/7854_2023_429
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