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The MATRICS Consensus Cognitive Battery: An Update

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Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 63))

Abstract

Through a series of NIMH-supported consensus-building meetings of experts and empirical comparisons of candidate tests, the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative developed a battery of standardized cognitive measures to allow reliable evaluation of results from clinical trials of promising interventions for core cognitive deficits in this disorder. Ten tests in seven cognitive domains were selected for the MATRICS Consensus Cognitive Battery (MCCB). The MCCB has now been translated into 39 languages/dialects and has been employed in more than 145 clinical trials. It has become the standard cognitive change measure for studies of both pharmacological and training-based interventions seeking to improve cognitive deficits in schizophrenia. We summarize its applications and its relationship to the subsequent development of the NIMH RDoC Matrix.

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Authors and Affiliations

  1. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA

    Keith H. Nuechterlein, Michael F. Green & Robert S. Kern

  2. Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA

    Keith H. Nuechterlein

  3. VISN 22 Mental Illness Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA

    Michael F. Green & Robert S. Kern

Authors
  1. Keith H. Nuechterlein
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  2. Michael F. Green
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  3. Robert S. Kern
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Correspondence to Keith H. Nuechterlein .

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Editors and Affiliations

  1. Departments of Psychological and Brain Sciences, Psychiatry, and Radiology, Washington University, Saint Louis, MO, USA

    Deanna M. Barch

  2. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    Jared W. Young

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Nuechterlein, K.H., Green, M.F., Kern, R.S. (2022). The MATRICS Consensus Cognitive Battery: An Update. In: Barch, D.M., Young, J.W. (eds) Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework. Current Topics in Behavioral Neurosciences, vol 63. Springer, Cham. https://doi.org/10.1007/7854_2022_395

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