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Behavioral Neurobiology of Alcohol Addiction pp 709–727Cite as

Deep Brain Stimulation as a Therapy for Alcohol Addiction

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 13))

Abstract

Deep brain stimulation (DBS) has been firmly established as a therapy for movement disorders. Recently, evidence from case reports and small case series also suggests DBS to be effective in psychiatric disorders including addiction. Here we review the rationale of DBS in addiction and the selection of possible targets. We then consider evidence from animal models as well as human case studies. We conclude that DBS in particular of the nucleus accumbens (NAcc) represents a promising treatment option in addiction which deserves further investigation.

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Abbreviations

DBS:

Deep brain stimulation

LFP:

Local field potentials

ERP:

Event-related potentials

NAcc:

Nucleus accumbens

SNc:

Substantia nigra pars compacta

VTA:

Ventral tegmental area

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Acknowledgments

TFM and HJH are supported by the DFG and BMBF.

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Authors and Affiliations

  1. Clinic for Neurology, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Thomas F. Münte

  2. Department of Neurology, University of Magdeburg, Magdeburg, Germany

    Hans-Jochen Heinze

  3. School for Mental Health and Neuroscience, Maastricht Institute for Neuromodulative Development, Maastricht University and Medical Centre, Maastricht, The Netherlands

    Veerle Visser-Vandewalle

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  1. Thomas F. Münte
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  2. Hans-Jochen Heinze
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  3. Veerle Visser-Vandewalle
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Correspondence to Thomas F. Münte .

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Editors and Affiliations

  1. Abt. Psychopharmakologie, Zentralinstitut für Seelische Gesundheit, J 5, Mannheim, 68159, Germany

    Wolfgang H. Sommer

  2. Abt. Psychopharmakologie, Zentralinstitut für Seelische Gesundheit, J 5, Mannheim, 68159, Germany

    Rainer Spanagel

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Münte, T.F., Heinze, HJ., Visser-Vandewalle, V. (2012). Deep Brain Stimulation as a Therapy for Alcohol Addiction. In: Sommer, W., Spanagel, R. (eds) Behavioral Neurobiology of Alcohol Addiction. Current Topics in Behavioral Neurosciences, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28720-6_207

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