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Exploring MicroRNAs on NIX-Dependent Mitophagy

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Book cover Mitophagy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1759))

Abstract

The dysregulation of autophagy is implicated in many pathological disorders including infections, aging, neurodegenerative diseases, and cancer. Autophagy can be precisely controlled both transcriptionally and translationally. Accumulating evidences show that the autophagy response is regulated by microRNAs, which therefore becomes subject area of interest in recent years. Herein, we give a brief introduction of the recent advancement in the regulation of microRNA on autophagy, and then we focus on the microRNA regulation of the mitophagy receptor, NIX. Finally, we present the methodology on how to study it in detail.

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Acknowledgement

This work was supported by NSFC (No. 31401182), by the National Basic Research Program of China (2013CB910100), by the Natural Science Foundation of Guangdong Province, China (2014A030313533), by Yangfan Plan of Talents Recruitment Grant, Guangdong, China (Yue Cai Jiao [2015] 216, 4YF14007G), by the Science and Technology Planning Project, Guangdong, China (No. 2016A020215152), by Guangdong Medical Research Foundation (A2015332), and by Research Fund of Guangdong Medical University (M2014024, M2015001).

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Authors and Affiliations

  1. Institute of Neurology, Guangdong Key Laboratory of Age-related Cardiac-cerebral Vascular Disease, The Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China

    Wen Li, Hao Chen, Shupeng Li, Guanghong Lin & Du Feng

  2. The Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Medical School, Boston, MA, USA

    Du Feng

  3. Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Wen Li, Hao Chen, Shupeng Li, Guanghong Lin & Du Feng

Authors
  1. Wen Li
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  2. Hao Chen
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  3. Shupeng Li
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  4. Guanghong Lin
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  5. Du Feng
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Corresponding author

Correspondence to Du Feng .

Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

    Nobutaka Hattori

  2. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

    Shinji Saiki

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Li, W., Chen, H., Li, S., Lin, G., Feng, D. (2017). Exploring MicroRNAs on NIX-Dependent Mitophagy. In: Hattori, N., Saiki, S. (eds) Mitophagy. Methods in Molecular Biology, vol 1759. Humana Press, New York, NY. https://doi.org/10.1007/7651_2017_15

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  • DOI: https://doi.org/10.1007/7651_2017_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7749-9

  • Online ISBN: 978-1-4939-7750-5

  • eBook Packages: Springer Protocols

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