Neurological Regulation of the Bone Marrow Niche

Aerts-Kaya, Fatima; Ulum, Baris; Mammadova, Aynura; Köse, Sevil; Aydin, Gözde; Korkusuz, Petek; Uçkan-Çetinkaya, Duygu

doi:10.1007/5584_2019_398

Fatima Aerts-Kaya^5,6,
Baris Ulum^6,7,
Aynura Mammadova^5,6,
Sevil Köse⁸,
Gözde Aydin^5,6,
Petek Korkusuz^5,9 &
…
Duygu Uçkan-Çetinkaya^5,6

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1212))

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11 Citations
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Abstract

The bone marrow (BM) hematopoietic niche is the microenvironment where in the adult hematopoietic stem and progenitor cells (HSPCs) are maintained and regulated. This regulation is tightly controlled through direct cell-cell interactions with mesenchymal stromal stem (MSCs) and reticular cells, adipocytes, osteoblasts and endothelial cells, through binding to extracellular matrix molecules and through signaling by cytokines and hematopoietic growth factors. These interactions provide a healthy environment and secure the maintenance of the HSPC pool, their proliferation, differentiation and migration. Recent studies have shown that innervation of the BM and interactions with the peripheral sympathetic neural system are important for maintenance of the hematopoietic niche, through direct interactions with HSCPs or via interactions with other cells of the HSPC microenvironment. Signaling through adrenergic receptors (ARs), opioid receptors (ORs), endocannabinoid receptors (CRs) on HSPCs and MSCs has been shown to play an important role in HSPC homeostasis and mobilization. In addition, a wide range of neuropeptides and neurotransmitters, such as Neuropeptide Y (NPY), Substance P (SP) and Tachykinins, as well as neurotrophins and neuropoietic growth factors have been shown to be involved in regulation of the hematopoietic niche. Here, a comprehensive overview is given of their role and interactions with important cells in the hematopoietic niche, including HSPCs and MSCs, and their effect on HSPC maintenance, regulation and mobilization.

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Abbreviations

2-AG:: 2-ArachidonoylGlycerol
ACh:: acetylcholine
AEA:: Anandamide
AGM:: aorta-gonad-mesonephros
ARs:: adrenergic receptors
BDNF:: Brain-Derived Growth factor
BM:: bone marrow
CBD:: Cannabidiol
CD271:: Low affinity nerve growth factor receptor
CFU-F:: Colony Forming Unit-Fibroblast
CFU-GEMM:: Colony Forming Unit-Granulocyte/Erythrocyte/Monocyte/Megakaryocyte
ChAT:: choline acetyltransferase
CKs:: cytokines
CNS:: central nervous system
CNTF:: ciliary neurotrophic factor
CRs:: endocannabinoid receptors
CT-1:: cardiotrophin-1
CXCL12/SDF1:: Stromal Derived Factor-1
D:: Dopamine
DCs:: Dendritic cells
DRs:: dopamine receptors
E:: Epinephrine/Adrenaline
ECB:: Endocannabinoid
ECM:: extracellular matrix
ECs:: endothelial cells
EK:: Endokinin
FAAH:: fatty acid amide hydrolase
FGF:: Fibroblasts growth factor
FTOC:: fetal thymus organ cultures
G-CSF:: Granulocyte-Colony Stimulating Factor
GDNF :: glial cell-line derived neurotrophic factor
GDNF:: Glial-derived Neurotrophic Factor
GFLs:: GDNF family of ligands
GM-CSF:: Granulocyte/Macrophage-Colony Stimulating Factor
GPCRs:: G-protein coupled receptors
HGFs:: hematopoietic growth factors
HK-1:: Hemokinin-1
HSCs:: hematopoietic stem cells
HSPCs:: hematopoietic stem and progenitor cells
IL:: Interleukin
LIF:: Leukemia inhibiting factor
LSK cells:: Lin⁻Sca⁺c-kit⁺ cells
MIP1α:: Macrophage Inflammatory Protein-1alpha
MMP:: Metalloproteinase
MSCs:: mesenchymal stromal/stem cells
NE:: Norepinephrine/Noradrenaline
NGF:: Nerve growth factor
NK cell:: Natural Killer cell
NKA:: Neurokinin A
NKB:: Neurokinin B
NK-Rs:: Neurokinin receptors
NPY:: Neuropeptide Y
NTs:: Neurotrophins
OBs:: osteoblasts
ORs:: opioid receptors
OSM:: Oncostatin M
PAA:: periarterial adventitial cells
PDGF:: Platelet-derived growth factor
RET:: rearranged during transfection receptor
RTK:: receptor tyrosine kinase
SCF:: Stem Cell Factor
SNS:: sympathetic nervous system
SP:: Substance P
TGFβ:: Transforming Growth Factor
TH:: tyrosine hydrolase
THC:: Tetrahydrocannabinol
TK:: Tachykinins
TLRs:: Toll-like receptors
TNFR:: Tumor necrosis factor receptor
TNFα:: Tumor Necrosis Factor alpha
TPO:: Thrombopoietin
Trk:: tropomyosin receptor kinase
UCB:: Umbilical Cord Blood
VEGF:: Vascular endothelial growth factor
WT:: Wild type

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Acknowledgements

This manuscript was supported by grants from the Scientific and Technological Research Council of Turkey, project no 318S073 and the Hacettepe University, Scientific Research Project Coordination Unit TYL-2018-17435 and THD-2018-17209.

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Graduate School of Health Sciences, Department of Stem Cell Sciences, Hacettepe University, Ankara, Turkey
Fatima Aerts-Kaya, Aynura Mammadova, Gözde Aydin, Petek Korkusuz & Duygu Uçkan-Çetinkaya
Center for Stem Cell Research and Development, Hacettepe University, Ankara, Turkey
Fatima Aerts-Kaya, Baris Ulum, Aynura Mammadova, Gözde Aydin & Duygu Uçkan-Çetinkaya
Faculty of Arts and Sciences, Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
Baris Ulum
Faculty of Health Sciences, Department of Medical Biology, Atilim University, Ankara, Turkey
Sevil Köse
Faculty of Medicine, Department of Histology and Embryology, Hacettepe University, Ankara, Turkey
Petek Korkusuz

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Kursad Turksen

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Aerts-Kaya, F. et al. (2019). Neurological Regulation of the Bone Marrow Niche. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 6. Advances in Experimental Medicine and Biology(), vol 1212. Springer, Cham. https://doi.org/10.1007/5584_2019_398

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DOI: https://doi.org/10.1007/5584_2019_398
Published: 25 July 2019
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