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Respiratory Virology and Immunogenicity pp 35–40Cite as

Cytokines and Toll-Like Receptors in the Immune Response to Influenza Vaccination

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Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 836))

Abstract

Toll-like receptors (TLRs) are involved in immunogenicity. However, little information is available on the role of TLRs in the immune response to vaccination against influenza virus. The aim of the study was to analyze the relationship between the immunogenic response to influenza vaccine and the presence of soluble forms of TLRs and selected cytokines in the serum. There were two groups of subjects participating in the main protocol of the study: 55 chronically hemodialyzed patients (Group A) and 55 healthy volunteers (Group B) participated in the study. Both groups were vaccinated against influenza using a subunit Agrippal vaccine. The concentrations of human TNF-α, IL-1β/IL-1F2, IL-6, and IL-10 were measured by a high sensitivity enzyme-linked immunosorbent assay. The soluble forms of TLR-2, TLR-4, and TLR-7 were determined in serum samples by ELISA as well. The findings were that vaccination did not appreciably influence the level soluble TRL-2, TRL-4, and TRL-7 or the cytokines investigated either in patients on hemodialysis or in healthy volunteers. Nor were there any relevant correlations between Toll-like receptors or pro-inflammatory cytokines and the immune response to influenza vaccination. On the other hand, the study showed that Toll-like receptors are increased in hemodialyzed patients, which may enhance the anti-inflammatory IL-10 and counter the downgrade of the immune response to influenza vaccine.

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References

  • Beutler B (2004) Innate immunity: an overview. Mol Immunol 40:845–859

    Article  CAS  PubMed  Google Scholar 

  • Beutler B, Wagner H (2002) Toll-like receptor family members and their ligands. Curr Top Microbiol Immunol 270:121–143

    Google Scholar 

  • Beutler B, Hoebe K, Du X, Ulevitch RJ (2003) How to detect microbes and respond to them: the Toll-like receptors and their transducers. J Leukoc Biol 74:479–485

    Article  CAS  PubMed  Google Scholar 

  • Boehme KW, Compton T (2004) Innate sensing of viruses by Toll-like receptors. J Virol 78:7867–7873

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004) Innate antiviral responses by means of TRL-7-mediated recognition of single-stranded RNA. Science 303:1529–1531

    Article  CAS  PubMed  Google Scholar 

  • Geeraedts F, Goutagny N, Hornung V, Severa M, de Haan A, Pool J, Wilschut J, Fitzgerald KA, Huckriede A (2008) Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signaling. PLoS Pathog 4, 10.1371/journal.ppat.1000138

  • Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526–1529

    Article  CAS  PubMed  Google Scholar 

  • Janssens S, Beyaert R (2003) Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16:637–646

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Jeisy-Scot V, Kim JH, Davis WG, Cao W, Katz JM, Sambhara S (2012) TRL-7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice. J Virol 86:10988–10998

    Article  Google Scholar 

  • Kato HS, Sato M, Yoneyama M, Yamamoto S, Uematsu K, Matsui T, Tsuimura K, Takeda T, Fujita O, Takeuchi O, Akira S (2005) Cell-type specific involvement of RIG-1 in antiviral response. Immunity 23:19–28

    Article  CAS  PubMed  Google Scholar 

  • Kazimierczak K, Kopec W, Klinger M (2007) Toll-like receptors (TLR) in the pathogenesis of kidney diseases. Pol Merkur Lekarski 23(137):382–385 (in Polish)

    CAS  PubMed  Google Scholar 

  • Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S (2007) Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol 179:4711–4720

    Article  CAS  PubMed  Google Scholar 

  • Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ (2010) Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Sci Transl Med 2:25ra24. doi:10.1126/scitranslmed.3000759

    Article  PubMed  Google Scholar 

  • Lebouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, Griffin GE, Ferrara P, Schiffrin EJ, Morgan BP, Labéta MO (2003) Soluble forms of Toll-like receptor (TLR)2 capable of modulating TRL2 signaling are present in human plasma and breast milk. J Immunol 171:6680–6689

    Article  CAS  PubMed  Google Scholar 

  • Liew FY, Xu D, Brint EK, O'Neill LA (2005) Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol 5:446–458

    Article  CAS  PubMed  Google Scholar 

  • Martin M, Michalek SM, Katz J (2003) Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A. Infect Immun 71:2498–2500

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Orme I (2004) Adaptive immunity to mycobacteria. Curr Opin Immunol 7:58–61

    CAS  Google Scholar 

  • Pang IK, Iwasaki A (2011) Inflammasomes as mediators of immunity against influenza virus. Trends Immunol 32:34–41

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Sabroe I, Read RC, Whyte MK, Dockrell DH, Vogel SN, Dower SK (2003) Toll-like receptors in health and disease: complex questions remain. J Immunol 171:1630–1635

    Article  CAS  PubMed  Google Scholar 

  • Schmitz N, Beerli RR, Bauer M, Jegerlehner A, Dietmeier K, Maudrich M, Pumpens P, Saudan P, Bachmann MF (2012) Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection. Eur J Immunol 42:863–869

    Article  CAS  PubMed  Google Scholar 

  • Takeda K, Akira S (2004) TLR signaling pathways. Semin Immunol 16:3–9

    Article  CAS  PubMed  Google Scholar 

  • Werkling D, Jungi TW (2003) TOLL-like receptors linking innate and adaptive immune response. Vet Immunol Immunopathol 91:1–12

    Article  Google Scholar 

  • Wolf G, Bohlender J, Bondeva T, Roger T, Thaiss F, Wenzel UO (2006) Angiotensin II upregulates toll-like receptor 4 on mesangial cells. J Am Soc Nephrol 17:1585–1593

    Article  CAS  PubMed  Google Scholar 

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Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Family Medicine, Medical University of Wrocław, 1 Syrokomli St., Wrocław, 51-141, Poland

    A. Mastalerz-Migas & B. J. Sapilak

  2. Public Higher Medical Professional School in Opole, 68 Katowicka St., 45-060, Opole, Poland

    M. Pokorski

  3. Institute of Psychology, Opole University, Plac Staszica 1, 45-052, Opole, Poland

    M. Pokorski

  4. Department of Pediatric Nephrology, Medical University of Wrocław, Wrocław, Poland

    K. Kiliś-Pstrusińska

  5. Dialysis Center ‘Diaverum’, Nysa, Poland

    K. Doskocz

  6. Department of Influenza Research, National Influenza Center, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland

    L. B. Brydak

  7. Department of Immunology, Division of Biology, University of Szczecin, Szczecin, Poland

    L. B. Brydak

Authors
  1. A. Mastalerz-Migas
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  2. M. Pokorski
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  3. K. Kiliś-Pstrusińska
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  4. K. Doskocz
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  5. B. J. Sapilak
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  6. L. B. Brydak
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Corresponding author

Correspondence to A. Mastalerz-Migas .

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Editors and Affiliations

  1. Institute of Psychology, Opole University, Poland

    Mieczyslaw Pokorski

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© 2014 Springer International Publishing Switzerland

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Mastalerz-Migas, A., Pokorski, M., Kiliś-Pstrusińska, K., Doskocz, K., Sapilak, B.J., Brydak, L.B. (2014). Cytokines and Toll-Like Receptors in the Immune Response to Influenza Vaccination. In: Pokorski, M. (eds) Respiratory Virology and Immunogenicity. Advances in Experimental Medicine and Biology(), vol 836. Springer, Cham. https://doi.org/10.1007/5584_2014_25

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