An antigen that requires the presence of T cell help to stimulate the B cell to secrete antibody. Such antigens do not elicit a productive antibody response by B cells unless the B cell receives help from a CD4 T cell. Help is generally supplied in the form of both a contact-dependent signal via CD40 plus specific T cell-secreted cytokines. Generally, protein antigens are T-dependent antigens.
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© 2005 Springer-Verlag
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(2005). T Cell-Dependent Antigen. In: Vohr, HW. (eds) Encyclopedic Reference of Immunotoxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27806-0_1422
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DOI: https://doi.org/10.1007/3-540-27806-0_1422
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44172-4
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