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Poliovirus, Pathogenesis of Poliomyelitis, and Apoptosis

  • Chapter
Role of Apoptosis in Infection

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 289))

Abstract

Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it has been shown that PV-induced apoptosis is an important component of the tissue injury in the CNS of infected mice, which leads to paralysis. In this review the molecular biology of PV and the pathogenesis of poliomyelitis are briefly described, and then several models of PV-induced apoptosis are considered; the role of the cellular receptor of PV, CD155, in the modulation of apoptosis is also addressed.

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  1. Laboratoire des Virus Entérotropes et Stratégies Antivirales, Institut Pasteur, 75724, Paris Cedex 15, France

    B. Blondel, F. Colbere-Garapin & A. Wirotius

  2. Unité Postulante de Neuroimmunologie Virale, Institut Pasteur, 75724, Paris Cedex 15, France

    T. Couderc

  3. Groupe Virus et Immunité, Institut Pasteur, 75724, Paris Cedex 15, France

    F. Guivel-Benhassine

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  1. Bloomberg School of Public Health Department of Molecular Microbiology and Immunology, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD, 21205, USA

    Diane E. Griffin MD, PhD

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Blondel, B., Colbere-Garapin, F., Couderc, T., Wirotius, A., Guivel-Benhassine, F. (2005). Poliovirus, Pathogenesis of Poliomyelitis, and Apoptosis. In: Griffin, D.E. (eds) Role of Apoptosis in Infection. Current Topics in Microbiology and Immunology, vol 289. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27320-4_2

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