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References
Christensen G, Wang Y, Chien KR (1997) Physiological assessment of complex cardiac phenotypes in genetically engineered mice. Am J Physiol 272:H2513–H2524
Conway SJ, Kruzynska-Frejtag A, Kneer PL, Machnicki M, Koushik SV (2003) What cardiovascular defect does my prenatal mouse mutant have, and why? Genesis 35:1–21
Copp AJ (1995) Death before birth: clues from gene knockouts and mutations. Trends Genet 11:87–93
El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann WH, Jäckel E, Harding SE, Boknik P, Neumann J, Eschenhagen T (2003) Evidence for protein phosphatase inhibitor-1 playing an amplifier role in β-adrenergic signaling in cardiac myocytes. FASEB J 17:437–439
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T (2002) Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin. J Mol Cell Cardiol 34:441–453
Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P (1996) Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci USA 93:10887–10890
Fitzgerald SM, Gan L, Wickman A, Bergstrom G (2003) Cardiovascular and renal phenotyping of genetically modified mice: a challenge for traditional physiology. Clin Exp Pharmacol Physiol 30:207–216
Giraldo P, Montoliu L (2001) Size matters: use of YACs, BACs and PACs in transgenic animals. Transgenic Res 10: 83–103
Gosau N, Fahimi-Vahid M, Michalek C, Schmidt M, Wieland T (2002) Signalling components involved in the coupling of α1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes. Naunyn-Schmiedeberg’s Arch Pharmacol 365:468–476
Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766–1769
He TC, Zhou S, Da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509–2514
Heintz N (2001) BAC to the future: the use of bac transgenic mice for neuroscience research. Nat Rev Neurosci 2: 861–870
Hilal-Dandan R, Kanter JR, Brunton LL (2000) Characterization of G-protein signaling in ventricular myocytes from the adult mouse heart: differences from the rat. J Mol Cell Cardiol 32:1211–1221
Janssen PM, Schillinger W, Donahue JK, Zeitz O, Emami S, Lehnart SE, Weil J, Eschenhagen T, Hasenfuss G, Prestle J (2002) Intracellular β-blockade: overexpression of Gαi2 depresses the β-adrenergic response in intact myocardium. Cardiovasc Res 55:300–308
Ju H, Gros R, You X, Tsang S, Husain M, Rabinovitch M (2001) Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice. Proc Natl Acad Sci USA 98:7469–7474
Kellendonk C, Tronche F, Casanova E, Anlag K, Opherk C, Schutz G (1999) Inducible site-specific recombination in the brain. J Mol Biol 285:175–182
Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman CE, Seidman JG, Vatner SF (1999) An α-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. Am J Physiol 276:H1780–H1787
Korhonen J, Lahtinen I, Halmekyto M, Alhonen L, Janne J, Dumont D, Alitalo K (1995) Endothelial-specific gene expression directed by the tie gene promoter in vivo. Blood 86:1828–1835
Le Y, Sauer B (2000) Conditional gene knockout using cre recombinase. Methods Mol Biol 136:477–485
Li L, Miano JM, Mercer B, Olson EN (1996) Expression of the SM22α promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J Cell Biol 132:849–859
Mittmann C, Chung CH, Höppner G, Michalek C, Nose M, Schuh A, Eschenhagen T, Weil J, Pieske B, Hirt S, Wieland T (2002) Expression of 10 RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure. Cardiovasc Res 55:778–786
Neyroud N, Nuss HB, Leppo MK, Marban E, Donahue JK (2002) Gene delivery to cardiac muscle. Methods Enzymol 346:323–334
Pawloski-Dahm CM, Song G, Kirkpatrick DL, Palermo J, Gulick J, Dorn GW 2nd, Robbins J, Walsh RA (1998) Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice. Circulation 97:1508–1513
Rajewsky K, Gu H, Kuhn R, Betz UA, Muller W, Roes J, Schwenk F (1996) Conditional gene targeting. J Clin Invest 98:600–603
Regan CP, Manabe I, Owens GK (2000) Development of a smooth muscle-targeted cre recombinase mouse reveals novel insights regarding smooth muscle myosin heavy chain promoter regulation. Circ Res 87:363–369
Sarao R, Dumont DJ (1998) Conditional transgene expression in endothelial cells. Transgenic Res 7:421–427
Schlaeger TM, Bartunkova S, Lawitts JA, Teichmann G, Risau W, Deutsch U, Sato TN (1997) Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci USA 94:3058–3063
Soonpaa MH, Kim KK, Pajak L, Franklin M, Field LJ (1996) Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Physiol 271:H2183–H2189
Subramaniam A, Jones WK, Gulick J, Wert S, Neumann J, Robbins J (1991) Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice. J Biol Chem 266:24613–24620
Valencik ML, McDonald JA (2001) Codon optimization markedly improves doxycycline regulated gene expression in the mouse heart. Transgenic Res 10:269–275
Wettschureck N, Rutten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S (2001) Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes. Nat Med 7:1236–1240
Wiechert S, El-Armouche A, Rau T, Zimmermann WH, Eschenhagen T (2003) 24-h Langendorff-perfused neonatal rat heart to study the impact of adenoviral gene transfer. Am J Physiol 285: H907–914
Yu Z, Redfern CS, Fishman GI (1996) Conditional transgene expression in the heart. Circ Res 79:691–697
Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (2001) RGS-PX1, a GAP for Gαs and sorting nexin in vesicular trafficking. Science 294:1939–1942
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Hein, P., Michel, M.C., Leineweber, K., Wieland, T., Wettschureck, N., Offermanns, S. (2005). Receptor and Binding Studies. In: Dhein, S., Mohr, F.W., Delmar, M. (eds) Practical Methods in Cardiovascular Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26574-0_37
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DOI: https://doi.org/10.1007/3-540-26574-0_37
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