Summary
Hemoglobin degradation products result in brain injury after intracerebral hemorrhage (ICH). Recent studies found that intracerebral infusion of heme oxygenase inhibitors reduces hemoglobin- and ICH-induced brain edema in rats and pigs. The present study examined whether systemic use of zinc protoporphyrin (ZnPP), a heme oxygenase inhibitor, can attenuate brain edema, behavioral deficits, and brain atrophy following ICH.
All rats had intracerebral infusion of 100-μL autologous blood. ZnPP (1 nmol/hour/rat) or vehicle was given immediately or 6 hours following ICH. ZnPP was delivered intraperitoneally up to 14 days through an osmotic mini-pump. Rats were killed at day 3 and day 28 after ICH for brain edema and brain atrophy measurements, respectively. Behavioral tests were performed. We found that ZnPP attenuated brain edema in animals sacrificed 3 days after ICH (p < 0:05). ZnPP also reduced ICH-induced caudate atrophy (p < 0:05) and ventricular enlargement (p < 0:05). In addition, ZnPP given immediately or 6 hours after ICH improved neurological deficits (p < 0:05). In conclusion, systemic zinc protoporphyrin treatment started at 0 or 6 hours after ICH reduced brain edema, neurological deficits, and brain atrophy after ICH. These results indicate that heme oxygenase may be a new target for ICH therapeutics.
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© 2006 Springer-Verlag
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Gong, Y., Tian, H., Xi, G., Keep, R.F., Hoff, J.T., Hua, Y. (2006). Systemic zinc protoporphyrin administration reduces intracerebral hemorrhage-induced brain injury. In: Hoff, J.T., Keep, R.F., Xi, G., Hua, Y. (eds) Brain Edema XIII. Acta Neurochirurgica Supplementum, vol 96. Springer, Vienna. https://doi.org/10.1007/3-211-30714-1_50
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DOI: https://doi.org/10.1007/3-211-30714-1_50
Publisher Name: Springer, Vienna
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