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Chitosan for Biomaterials I pp 163–184Cite as

Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 243))

Abstract

Iron oxide nanoparticles (IONPs) are a new class of nanomaterials which have attracted extensive interest for application in in vivo magnetic resonance imaging (MRI) due to their intrinsic superparamagnetic and biodegradable properties. Performance of the IONPs is largely dependent upon the properties of their surface coatings, which serve to prevent nanoparticle agglomeration, reduce the risk of immunogenicity, and limit nonspecific cellular uptake. Among the coating materials studied to date, chitosan has drawn considerable attention. Commonly derived from crustacean shells, chitosan is a natural linear polysaccharide and has ample reactive functional groups that can serve as anchors for conjugation of therapeutics, targeting ligands, and imaging agents. Because of these unique attributes, chitosan-coated IONPs are becoming more desirable for cancer imaging and therapy applications. This chapter discusses the current advances and challenges in synthesis of chitosan-coated IONPs, and their subsequent surface modifications for applications in cancer diagnosis and therapy.

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Acknowledgments

This work is supported by NIH grants R01EB006043, and R01CA134213. O. Veiseh acknowledges support through the NIH/NCI training grant (T32CA138312).

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Authors and Affiliations

  1. Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA

    Hamed Arami, Zachary Stephen, Omid Veiseh & Miqin Zhang

Authors
  1. Hamed Arami
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  2. Zachary Stephen
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  3. Omid Veiseh
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  4. Miqin Zhang
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Corresponding author

Correspondence to Miqin Zhang .

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Editors and Affiliations

  1. , Amrita Center for Nanosciences and Molec, Amrita Institute of Medical Sciences and, Amrita Lane, Cochin, 682041, India

    R. Jayakumar

  2. , Department of Chemistry, SRM University, Kattankulathur, 603 203, India

    M. Prabaharan

  3. Faculty of Medicine, Institute of Biochemistry, University of Ancona, Ancona, 60100, Italy

    Riccardo A. A. Muzzarelli

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Arami, H., Stephen, Z., Veiseh, O., Zhang, M. (2011). Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery. In: Jayakumar, R., Prabaharan, M., Muzzarelli, R. (eds) Chitosan for Biomaterials I. Advances in Polymer Science, vol 243. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2011_121

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