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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function

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Polymer Therapeutics II

Part of the book series: Advances in Polymer Science ((POLYMER,volume 193))

Abstract

Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work in related fields over the last decade, a drug carrier based on polymeric micelles has been created. Advances in polymer chemistry have significantly contributed to progress in polymeric micelle-based drug carrier research, because the micelle parameters that are most important to successful drug delivery can be modulated by engineering the structures of the micelle-forming block copolymers. More intelligent polymeric micelles enabling environmentally-sensitive drug release and cell type-specific targeting have also recently emerged and have attracted increasing interest in the field of polymer chemistry. This paper therefore reviews recent progress in research on polymeric micelles for drug delivery, focusing upon the relationship between the chemical design of polymeric micelles and their physicochemical and biological properties.

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Abbreviations

ADR:

Adriamycin

AFM:

Atomic force microscopy

AmB:

Amphotericin B

ASGP:

Asialoglycoprotein

BPEI:

Branched polyethyleneimine

CDDP:

cis-Diamminedichloroplatinum(II), cisplatin

CL:

ε-Caprolactone

CMC:

Critical micelle concentration

CNV:

Choroidal neovascularization

DDS:

Drug delivery system

DMAc:

N,N-Dimethylacetamide

DPT:

Dipropylene triamine

EO:

Ethylene oxide

EPR effect:

Enhanced permeability and retention effect

FDA:

Food and Drug Administration

GA:

Glycolic acid

LCST:

Lower critical solution temperature

LPEI:

Linear polyethyleneimine

NCA:

N-carboxyanhydride

ODN:

Oligonucleotides

PCL:

Poly(ε-caprolactone)

PDLLA:

Poly(d,l-lactide)

pDNA:

Plasmid DNA

PEO:

Poly(ethylene oxide)

PEO-b-ODN:

PEO-b-oligonucleotide

PEO-b-DPT:

PEO-b-poly(3-[(3-aminopropyl)amino]propylaspartamide)

PEO-b-PAAs:

PEO-b-poly(amino acids)

PEO-b-PAMA:

PEO-b-poly[(2-dimethylamino)ethyl methacrylate]

PEO-P(Asp-ADR):

PEO-b-poly(α,β-aspartic acid)

PEO-b-P(Asp):

Adriamycin-conjugated PEO-b-P(Asp)

PEO-b-P(Asp-Hyd):

PEO-b-P(Asp) processing the hydrazide groups in the side chains

PEO-b-PBLA:

PEO-b-poly(β-benzyl l-aspartate)

PEO-b-PCL:

PEO-b-poly(ε-caprolactone)

PEO-b-PDLLA:

PEO-b-poly(d,l-lactide)

PEO-b-PE:

PEO-b-phosphatidylethanolamine

PEO-b-PEE:

PEO-b-polyethylethylene

PEO-b-P(Glu):

PEO-b-poly(glutamic acid)

PEO-b-P(His):

PEO-b-poly(l-histidine)

PEO-b-PLGA:

PEO-b-poly(lactide-co-glycolic acid)

PEO-b-PLA:

PEO-b-poly(lactide)

PEO-b-PLLA:

PEO-b-poly(l-lactide)

PEO-b-P(Lys):

PEO-b-poly(l-lysine)

PEO-b-P(Lys-IM):

PEO-b-P(Lys) that has the side chain partially substituted with a 1-imino-4-mercaptobutyl group

PEO-b-P(Lys-MP):

PEO-b-P(Lys) that has the side chain partially substituted with a 3-mercaptopropionyl group

PEO-b-P(Lys(Z)):

PEO-b-poly(ε-benzyloxycarbonyl l-lysine)

PGA:

Poly(glycolic acid)

P(His):

Poly(l-histidine)

PIC:

Polyion complex

PLA:

Poly(lactide)

PLLA:

Poly(l-lactide)

Pluronic:

PEO-b-poly(propylene oxide)-b-PEO

P(Lys):

Poly(l-lysine)

pNP:

p-Nitrophenylcarbonyl group

RES:

Reticuloendothelial system

siRNA:

Small interfering RNA

SPDP:

3-(2-Pyridyldithio)propionate

TEM:

Transmission electron microscopy

T g :

Glass transition temperature

32(−)DP:

Third generation dendrimer with 32 carboxylic acid groups on the periphery

32(+)DP:

Third generation dendrimer with 32 quaternary trimethylamino groups on the periphery

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Authors and Affiliations

  1. Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan

    Nobuhiro Nishiyama & Kazunori Kataoka

  2. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan

    Kazunori Kataoka

Authors
  1. Nobuhiro Nishiyama
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  2. Kazunori Kataoka
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Correspondence to Kazunori Kataoka .

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Ronit Satchi-Fainaro Ruth Duncan

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Nishiyama, N., Kataoka, K. Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function. In: Satchi-Fainaro, R., Duncan, R. (eds) Polymer Therapeutics II. Advances in Polymer Science, vol 193. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_025

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