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Microfluidics pp 171–201Cite as

Optical Detection Systems on Microfluidic Chips

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 304))

Abstract

Optical detection continues to dominate detection methods in microfluidics due to its noninvasive nature, easy coupling, rapid response, and high sensitivity. In this review, we summarize two aspects of recent developments in optical detection methods on microfluidic chips. The first aspect is free-space (off-chip) detection on the microchip, in which the conventional absorption, fluorescence, chemiluminescence, surface plasmon resonance, and surface enhanced Raman spectroscopies are involved. The second aspect is the optofluidic (inside-chip) detection. Various miniaturized optical components integrated on the microfluidic chip, such as waveguide, microlens, laser, and detectors are outlined.

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Abbreviations

μ-TAS:

Micro total analysis system

ARROWs:

Antiresonant reflecting optical waveguides

CCD:

Charge-coupled device

CE:

Capillary electrophoresis

CL:

Chemiluminescence

CMOS:

Complementary metal-oxide-semiconductor

DFB:

Distributed feedback

HRP:

Horseradish peroxidase

L2 waveguide:

Liquid-core/liquid-cladding waveguide

LCW:

Liquid-core waveguide

LED:

Light-emitting diode

L-GRIN:

Liquid gradient refractive index

LIF:

Laser-induced fluorescence

(L)SPR:

(Localized) surface plasmon resonance

OFM:

Optofluidic microscopy

OPD:

Organic photodiode

PC:

Photonic crystal

PDMS:

Poly(dimethylsiloxane)

PMMA:

Poly(methyl methacrylate)

PMTs:

Photomultiplier tubes

QD:

Quantum dot

SERS:

Surface enhanced Raman spectroscopy

UV/Vis:

Ultraviolet–visible

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Acknowledgments

The authors would like to thank Xingbo Shi, Xinliang Liu, Lichun Sun, and Haixia Ding for helpful discussions. HWG gratefully acknowledges the support of National Natural Science Foundation of China (20705007, 21075033, 20703016).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, China

    Hongwei Gai

  2. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082, China

    Hongwei Gai, Yongjun Li & Edward S. Yeung

  3. School of Biology, Hunan University, Changsha, 410082, China

    Hongwei Gai & Edward S. Yeung

  4. School of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    Yongjun Li

Authors
  1. Hongwei Gai
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  2. Yongjun Li
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  3. Edward S. Yeung
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Corresponding authors

Correspondence to Hongwei Gai or Yongjun Li .

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Editors and Affiliations

  1. The Chinese Academy of Sciences, Laboratory of Biotechnology, Dalian Institute of Chemical Physics, ZhongShan Road 457, Dalian, 116023, China, People's Republic

    Bingcheng Lin

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Gai, H., Li, Y., Yeung, E.S. (2011). Optical Detection Systems on Microfluidic Chips. In: Lin, B. (eds) Microfluidics. Topics in Current Chemistry, vol 304. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_144

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