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Engineered MSCs from Patient-Specific iPS Cells

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Mesenchymal Stem Cells - Basics and Clinical Application II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 130))

Abstract

Mesenchymal stroma/stem cells (MSCs) represent a heterogenic cell population that can be isolated from various tissues of the body or can be generated from pluripotent stem cells by in vitro differentiation. Various promising pre-clinical and clinical studies suggest that MSCs might stimulate endogenous regeneration and/or act as anti-inflammatory agents, which could be of high therapeutic relevance for a number of diseases, including graft-versus-host disease after allogeneic hematopoietic stem cell transplantation, inflammatory bowel diseases, or some forms of liver failure. Notably, conflicting results of various studies illustrated that the source of MSCs, the cultivation condition, and the way of administration have important effects on the desired clinical effect. Some of the involved molecular pathways have recently been elucidated and an artificial modulation of these pathways by engineered MSCs might result in superfunctional MSCs for enhanced endogenous regeneration or anti-inflammatory response. In this review, we summarize important findings of conventional MSCs for applications in gastroenterology and we describe the state-of-the-art for the generation of patient-derived iPS cells that eventually might provide genetically engineered superfunctional iPS cells for advanced cell therapies.

Graphical Abstract

Irina Eberle and Mohsen Moslem contributed equally

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Acknowledgments

We are very grateful to the members of our lab providing intensive discussions and much critical input, which contributed to this review. M.M. and T.C. receive funding from the cluster of excellence REBIRTH (REgenerative BIology and Reconstructive THerapy), which is funded by the German Research Foundation (DFG; EXC 62/1). I.E. receives funding from the Centre for Cell and Gene Therapy of the LOEWE initiative. Further funding is provided by the Federal Ministry of Education and Research through grants 01GM1110A, 01GP1007C, as well as by the José Carreras leukemia foundation (DJCLS R11/22f).

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Authors and Affiliations

  1. Junior Research Group Stem Cell Biology, OE 8881, Cluster-of-Excellence REBIRTH, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Irina Eberle, Mohsen Moslem & Tobias Cantz

  2. DRK-Institute of Transfusion Medicine and Immune Hematology, Frankfurt, Germany

    Irina Eberle & Reinhard Henschler

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  1. Irina Eberle
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  2. Mohsen Moslem
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  3. Reinhard Henschler
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  4. Tobias Cantz
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Correspondence to Tobias Cantz .

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Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy

    Massimo Dominici

  3. Medizinische Hochschule Hannover, AG Biochemie und Tumorbiologie, Klinik für Frauenheilkunde und Geburtshilfe, Hannover, Germany

    Ralf Hass

  4. Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Wien, Austria

    Cornelia Kasper

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Eberle, I., Moslem, M., Henschler, R., Cantz, T. (2012). Engineered MSCs from Patient-Specific iPS Cells. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application II. Advances in Biochemical Engineering/Biotechnology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_156

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