Skip to main content
SpringerLink
Log in

Sensors in Disposable Bioreactors Status and Trends

  • Chapter
  • First Online:
Disposable Bioreactors

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 115))

Abstract

For better control of productivity and product quality, detailed monitoring of various parameters is required. Since disposable bioreactors become more and more important for biotechnological applications, adequate sensors for this type of reactor are necessary. The required properties of sensors used in disposable reactors differ from those of sensors for multiuse reactors. For example, sensors which are in direct contact with the medium must be inexpensive, but do not need a long life-time, since they can be used only once.

This chapter gives an overview on the state of the art and future trends in the field of sensors suited for use in disposable bioreactors. The main focus here is on in situ sensors, which can be based on optical, semiconductor and ultrasonic technologies, but current concepts for disposable sampling units are also reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 379.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

κ :

Adiabatic compressibility

κ c :

Conductivity

κ cell :

Cell constant

ρ:

Density

ATR:

Attenuated total reflectance

CA:

Commercially available

CIP:

Cleaning in place

c US :

Velocity of ultrasonic wave

I Drain :

Drain current

IR:

In research

ISFET:

Ion-sensitive field-effect transistor

JFET:

Junction field-effect transistor

MOSFET:

Metal oxide semiconductor field-effect transistor

NA:

Not available

NIR:

Near infrared

PAT:

Process analysis technology

pHFET:

pH-sensitive ISFET

R:

Resistance

SIP:

Sterilization in place

SWIR:

Short wave infrared

U Drain :

Drain voltage

U Gate :

Gate voltage

References

  1. Novais J, Titchener-Hooker N, Hoare M (2001) Biotechnol Bioeng 75:143

    Article  CAS  Google Scholar 

  2. Farid S, Washbrook J, Titchener-Hooker N (2005) Biotechnol Bioeng 21:486

    CAS  Google Scholar 

  3. Chirvase AA, Dumitrache I, Caramihai MD (2007) Rev Roum Chim 52:621

    CAS  Google Scholar 

  4. Becker T, Hitzmann B, Muffler K, Portner R, Reardon KF, Stahl F, Ulber R (2007) Adv Biochem Eng Biotechnol 105:249

    CAS  Google Scholar 

  5. Junker BH, Wang HY (2006) Biotechnol Bioeng 95:226

    Article  CAS  Google Scholar 

  6. Rhee IL, Ritzka A, Scheper T (2004) Biotechnol Bioprocess Eng 9:156

    Article  CAS  Google Scholar 

  7. O’Flaherty B (2004) Gen Eng News 24:54

    Google Scholar 

  8. Schugerl K (2001) J Biotechnol 85:149

    Article  CAS  Google Scholar 

  9. Scheper T, Hitzmann B, Stark E, Ulber R, Faurie R, Sosnitza P, Reardon KF (1999) Anal Chim Acta 400:121

    Article  CAS  Google Scholar 

  10. Rehbock C, Beutel S, Brückerhoff T, Hitzmann B, Riechers D, Rudolph G, Stahl F, Scheper T, Friehs K (2008) Chem Eng Technol 80:267

    CAS  Google Scholar 

  11. Ulber R, Hitzmann B, Scheper T (2001) Chem Eng Technol 73:19

    CAS  Google Scholar 

  12. Hilmer JM, Scheper T (1996) Acta Biotechnol 16:185

    Article  CAS  Google Scholar 

  13. http://www.grotonbiosystems.com/pressroom/press_docs/MKT-046_ProductBulletin_SampleProbe.pdf. Accessed 27 May 2008

  14. Kinney S, Phillips C (2007) BioProcess Int 5:52

    Google Scholar 

  15. http://www.cellexusbiosystems.com/index_files/Cellexussampler.pdf. Accessed 20 Mar 2008

  16. Furey J, Proulx S (2007) US Patent 7,293,477 B2

    Google Scholar 

  17. Scheper T et al (1999) Anal Chim Acta 400:121

    Article  CAS  Google Scholar 

  18. Marose S et al (1999) Trends Biotechnol 17:30

    Article  CAS  Google Scholar 

  19. Schugerl K (2001) J Biotechnol 85:149

    Article  CAS  Google Scholar 

  20. Wolfbeis OS et al (2005) J Mater Chem 15:2657

    Article  CAS  Google Scholar 

  21. Scheper T, Schugerl K (1986) J Biotechnol 3:221

    Article  CAS  Google Scholar 

  22. Ulber R et al. (2003) Anal Bioanal Chem 376:342

    CAS  Google Scholar 

  23. Scheper T, Gebauer A, Kuhlmann W, Meyer HD, Schügerl K (1984) DECHEMA-Monographien, Verlag Chemie, 95:83

    CAS  Google Scholar 

  24. Scheper T, Gebauer A, Sauerbrei A, Niehoff A, Schügerl K (1984) Anal Chim Acta 163:111

    Article  CAS  Google Scholar 

  25. Scheper T, Schügerl K (1986) J Biotechnol 3:221

    Article  CAS  Google Scholar 

  26. Scheper T, Schügerl K (1986) Chem Eng Technol 58:433

    CAS  Google Scholar 

  27. Scheper T, Schügerl K (1986) Appl Microbiol Biotechnol 23:440

    Article  CAS  Google Scholar 

  28. Schügerl K, Lorenz T, Lübbert A, Niehoff J, Scheper T, Schmidt W (1986) Trends Biotechnol 4:11

    Article  Google Scholar 

  29. Reardon KF, Scheper T, Bailey JE (1986) Biotechnol Lett 8:817

    Article  CAS  Google Scholar 

  30. Gebauer A, Scheper T, Schügerl K (1987) Bioprocess Eng 2:13

    Article  Google Scholar 

  31. Scheper T, Gebauer A, Schügerl K (1987) Chem Eng J 34:B7

    Article  CAS  Google Scholar 

  32. Scheper T, Lorenz T, Schmidt W, Schügerl K (1987) Ann N Y Acad Sci 506:431

    Article  CAS  Google Scholar 

  33. Reardon KF, Scheper T, Bailey JE (1987) Chem Eng Technol 59:600

    CAS  Google Scholar 

  34. Schügerl K, Lübbert A, Scheper T (1987) Chem Eng Technol 59:701

    Google Scholar 

  35. Reardon KF, Scheper T, Bailey JE (1987) Biotechnol Progress 3:153

    Article  CAS  Google Scholar 

  36. Müller W, Wehnert G, Scheper T (1988) Anal Chim Acta 213:47

    Article  Google Scholar 

  37. Müller W, Anders KD, Scheper T (1989) Chem Eng Technol 61:564

    Google Scholar 

  38. Scheper T, Bückmann FA (1990) Biosens Bioelectron 5:125

    Article  CAS  Google Scholar 

  39. Wehnert G, Anders KD, Bittner C, Kammeyer R, Hübner U, Niellsen J, Scheper T (1990) Chem Eng Technol 6:211

    Google Scholar 

  40. Scheper T (1990) Biotech Forum Eur 7:67

    CAS  Google Scholar 

  41. Reardon KF, Scheper T, Anders KD, Müller W, Bückmann AF (1990) Appl Biochem Biotechnol 24/25:363

    Article  Google Scholar 

  42. Schügerl K, Lübbert A, Scheper T (1990) Int Chem Eng 30:433

    Google Scholar 

  43. Scheper T, Brandes W, Grau C, Hundeck HG, Reinhardt B, Rüther F, Plötz F, Schelp C, Schügerl K, Schneider KH, Fiffhorn F, Rehr B, Sahm H (1991) Anal Chim Acta 249:25

    Article  CAS  Google Scholar 

  44. Plötz F, Schelp C, Anders KD, Eberhardt F, Scheper T (1991) Proc SPIE 1510:224

    Article  Google Scholar 

  45. Scheper T (1992) J Ind Microbiol 9:163

    Article  CAS  Google Scholar 

  46. Anders KD, Aknoukh R, Scheper T, Kretzmer G (1992) Chem Eng Technol 64:572

    CAS  Google Scholar 

  47. Rhee JI et al (2005) Biochem Eng J 22:135

    Article  CAS  Google Scholar 

  48. Hagedorn A et al (2004) Biotechnol Progr 20:361

    Article  CAS  Google Scholar 

  49. Sato K et al (2000) J Biosci Bioeng 90:294

    CAS  Google Scholar 

  50. Anders KD, Wehnert G, Thordsen O, Scheper T, Rehr B, Sahm H (1993) Sens Actuators B 11:395

    Article  Google Scholar 

  51. Thordsen O, Lee SJ, Degelau A, Scheper T, Loos H, Rehr B, Sahm H (1993) Biotechnol Bioeng 42:387

    Article  CAS  Google Scholar 

  52. Müller C, Kohls O, Comte A, Scheper T (1993) Chem Eng Technol 65:1086

    Google Scholar 

  53. Schügerl K, Bellgardt KH, Kretzmer G, Hitzmann B, Scheper T (1993) Chem Eng Technol 65:1447

    Google Scholar 

  54. Marose S, Lindemann C, Ulber R, Scheper T (1999) Trends Biotechnol 17:30

    Article  CAS  Google Scholar 

  55. Scheper T, Lammers F (1994) Curr Opin Biotechnol 5:187

    Article  CAS  Google Scholar 

  56. Mukherjee J, Lindemann C, Scheper T (1999) Appl Microbiol Biotechnol 52:489

    Article  CAS  Google Scholar 

  57. Tartakovsky B, Sheintuch M, Hilmer JM, Scheper T (1996) Biotechnol Progr 12:126

    Article  CAS  Google Scholar 

  58. Scheper T, Hilmer JM, Lammers F, Müller C, Reinecke M (1996) J Chromat A 725:3–12

    Article  Google Scholar 

  59. Knüttel T, Hartmann T, Meyer H, Scheper T (2001) Enzyme Microb Technol 29:150

    Article  Google Scholar 

  60. Müller C, Hitzmann B, Schubert F, Scheper T (1997) Sens Actuators B 40:71

    Article  Google Scholar 

  61. Marose S, Lindemann C, Scheper T (1998) Biotechnol Progr 14:63

    Article  CAS  Google Scholar 

  62. Schügerl K, Lindemann C, Marose S, Scheper T. (1998) Bioprocess Eng Course 400

    Google Scholar 

  63. Pekeler T, Lindemann C, Scheper T, Hitzmann B (1998) Chem Eng Technol 70:1610

    CAS  Google Scholar 

  64. Marose S, Lindemann C, Ulber R, Scheper T (1999) Trends Biotechnol 17:30

    Article  CAS  Google Scholar 

  65. Lindemann C, Marose S, Scheper T, Nielsen HO, Reardon KF (1999) Encyclopedia of bioprocess technology: fermentation, biocatalysis and bioseparation. Wiley, New York, p 1239

    Google Scholar 

  66. Mukherjee J, Lindemann C, Scheper T (1999) Appl Microbiol Biotechnol 52:489

    Article  CAS  Google Scholar 

  67. Scheper T, Hitzmann B, Stärk E, Ulber R, Faurie R, Sosnitza P, Reardon KF (1999) Anal Chim Acta 400:121

    Article  CAS  Google Scholar 

  68. Ulber R, Hitzmann B, Scheper T, Reardon KF (2000) Enyclopedia of Microbiology, vol. 1. Academic, New York, p 567

    Google Scholar 

  69. Knüttel T, Hartmann T, Meyer H, Scheper T (2001) Enzyme Microb Technol 29:150

    Article  Google Scholar 

  70. Ulber R, Protsch C, Solle D, Hitzmann B, Willke B, Faurie R, Scheper T (2001) Eng Life Sci 1:15

    Article  CAS  Google Scholar 

  71. Stärk E, Hitzmann B, Schügerl K, Scheper T, Fuchs C, Köster D, Märkl H (2002) Adv Biochem Eng Biotechnol 74:22

    Google Scholar 

  72. Bartolome A, Ulber R, Scheper T, Sagi E, Belkin S (2003) Sens Actuators B 89:27

    Article  Google Scholar 

  73. Sagi E, Hever N, Rosen R, Bartolome A, Premkumas JR, Ulber R, Lev O, Scheper T, Belkin S (2003) Sens Actuators B 90:2

    Article  CAS  Google Scholar 

  74. Knüttel T, Meyer H, Scheper T (2005) Anal Chem 77:6184

    Article  CAS  Google Scholar 

  75. Hantelmann K, Kollecker M, Hüll D, Hitzmann B, Scheper T (2005) J Biotechnol 121:410

    Article  CAS  Google Scholar 

  76. Knüttel T, Meyer H, Scheper T (2006) Enzyme Microb Technol 39:607

    Article  CAS  Google Scholar 

  77. Ganzlin M, Marose S, Lu X, Hitzmann B, Scheper T, Rinas U (2007) J Biotechnol 132:461

    Article  CAS  Google Scholar 

  78. Tartakovsky B et al (1996) Biotechnol Prog 12:126

    Article  CAS  Google Scholar 

  79. Pekeler T et al (1998) Chem Eng Technol 70:1610

    CAS  Google Scholar 

  80. Tartakovsky B, Sheintuch M, Hilmer JM, Scheper T (1997) Bioprocess Eng 16:323

    CAS  Google Scholar 

  81. Hitzmann B, Broxtermann O, Cha YL, Sobieh O, Stärk E, Scheper T (2000) Bioprocess Eng 23:337

    Article  CAS  Google Scholar 

  82. Solle D, Geissler D, Stärk E, Scheper T, Hitzmann B (2003) Bioinformatics 19:173

    Article  CAS  Google Scholar 

  83. Boehl D, Solle D, Hitzmann B, Scheper T (2003) J Biotechnol 105:179

    Article  CAS  Google Scholar 

  84. Geissler D, Solle D, Stärk E, Scheper T, Märkl H, Hitzmann B (2003) Eng Life Sci 3:397

    Article  CAS  Google Scholar 

  85. Surribas A, Geissler D, Gierse A, Scheper T, Hitzmann B, Motesinos JL, Valero F (2006) J Biotechnol 124:412

    Article  CAS  Google Scholar 

  86. Arnold SA et al. (2002) Biotechnol Bioeng 80:405

    Article  CAS  Google Scholar 

  87. Mazarevica G et al. (2004) Appl Spectrosc 58:804

    Article  CAS  Google Scholar 

  88. Armenta S et al. (2005) Anal Chim Acta 545:99

    Google Scholar 

  89. Scheper T et al. (1999) Anal Chim Acta 400:121

    Article  CAS  Google Scholar 

  90. Köneke R, Comte A, Jürgens H, Kohls O, Lam H, Scheper T (1998) Chem Eng Technol 70:1661

    Google Scholar 

  91. Kohls O, Scheper T (2000) Sens Actuators B 70:121

    Article  Google Scholar 

  92. Tservistas M, Köneke R, Comte A, Scheper T (2001) Enzyme Microb Technol 28:637

    Article  CAS  Google Scholar 

  93. Frerichs JG, Joeris K, Konstantinov K, Scheper T (2002) Chem Eng Technol 74:1629

    CAS  Google Scholar 

  94. Joeris K, Scheper T (2003) J Colloid Interf Sci 267:369

    Article  CAS  Google Scholar 

  95. Surribas A, Geissler D, Gierse A, Scheper T, Hitzmann B, Motesinos JL, Valero F (2006) J Biotechnol 124:412

    Article  CAS  Google Scholar 

  96. Klimant I et al (1997) Sens Actuators B 38:29

    Article  Google Scholar 

  97. Lam HT. (2002) Dissertation, University of Hanover

    Google Scholar 

  98. Lai SW et al. (2004) Inorg Chem 43:3724

    Article  CAS  Google Scholar 

  99. Park EJ et al. (2005) J Mater Chem 15:2913

    Article  CAS  Google Scholar 

  100. Munkholm C, Walt DR (1998) Talanta 35:109

    Article  Google Scholar 

  101. Mills A, Chang Q (1993) Analyst 118:839

    Article  CAS  Google Scholar 

  102. Fritzsche M, Barreiro CG, Hitzmann B, Scheper T (2007) Sens Actuators B 128:133

    Article  CAS  Google Scholar 

  103. Mills A, Chang Q, McMurray (1992) Anal Chem 64:1383

    Article  CAS  Google Scholar 

  104. Tan W et al. (1992) Anal Chem 64:2985

    Article  CAS  Google Scholar 

  105. Lu J, Rosenzweig Z (2000) Fresenius Z Anal Chem 366:575

    Google Scholar 

  106. Dremel BA et al. (1992) Chem Eng Technol 64:510

    CAS  Google Scholar 

  107. Kermis HR, Kostov Y, Rao G (2003) Analyst 128:1181

    Article  CAS  Google Scholar 

  108. Severinghaus JW, Bradley AF (1958) J Appl Phys 13:515

    CAS  Google Scholar 

  109. Uttamlal M, Walt DR (1995) BioTechnology 13:597

    Article  CAS  Google Scholar 

  110. Ge X, Kostov Y, Rao G (2003) Biosens Bioelectron 18:857

    Article  CAS  Google Scholar 

  111. Weigl BH, Wolfbeis OS (1995) Sens Actuators B 28:151

    Article  Google Scholar 

  112. Suhr H, Wehnert G, Schneider K, Bittner C, Scholz T, Geissler P, Jahne B, Scheper T (1995) Biotechnol Bioeng 47:106

    Article  CAS  Google Scholar 

  113. Bittner C, Wehnert G, Scheper T (1998) Biotechnol Bioeng 60:24

    Article  CAS  Google Scholar 

  114. Rudolph G, Bruckerhoff T, Bluma A, Korb G, Scheper T (2007) Chem Eng Technol 79:42

    CAS  Google Scholar 

  115. Joeris K, Frerichs J, Konstantinov K, Scheper T (2002) Cytotechnology 38:129

    Article  CAS  Google Scholar 

  116. Frerichs JG, Joeris K, Konstantinov K, Scheper T (2002) Chem Eng Technol 74:1629

    CAS  Google Scholar 

  117. Joeris K, Scheper T (2003) J Colloid Interf Sci 267:369

    Article  CAS  Google Scholar 

  118. Anton F, Burzlaff A, Kasper C, Bruckerhoff T, Scheper T (2007) Eng Life Sci 7:91

    Article  CAS  Google Scholar 

  119. Wise KD, Angell JB, Starr A (1970) IEEE Trans Biomed Eng 17:238

    Article  CAS  Google Scholar 

  120. Bergveld P (1968) IEEE Trans Biomed Eng 15:102

    Article  Google Scholar 

  121. Bergveld P (1970) IEEE Trans Biomed Eng 17:70

    Article  CAS  Google Scholar 

  122. Bergveld P (1972) IEEE Trans Biomed Eng 19:342

    Article  CAS  Google Scholar 

  123. Yates DE, Levine S, Healy TW (1974) J Chem Soc 70:1807

    CAS  Google Scholar 

  124. Vanhal REG, Eijkel JCT, Bergveld P (1995) Sens Actuators B 24:201

    Article  Google Scholar 

  125. Bergveld P, Vanhal REG, Eijkel JCT (1995) Biosens Bioelectron 10:405

    Article  CAS  Google Scholar 

  126. van Hal REG, Eijkel JCT, Bergveld P (1996) Adv Colloid Interface Sci 69:31

    Article  CAS  Google Scholar 

  127. Khanna VK et al. (2007) Indian J Eng Mater Sci 14:112

    CAS  Google Scholar 

  128. Kullick T, Ulber R (1995) In: Freitag R. (ed) Biosensors in analytical biotechnology. Landes Bioscience, Austin

    Google Scholar 

  129. Migita S et al. (2007) Anal Sci 23:45

    Article  Google Scholar 

  130. Scheper T, Reardon KF (1991) In: Göpel W, Hesse J, Memel JN. (eds) Sensors, vol 2. VCH, Weinheim, p 1024

    Google Scholar 

  131. Brand U, Reinhardt B, Rüther F, Scheper T, Schügerl K (1991) Sens Actuators B 4:315

    Article  Google Scholar 

  132. Kullick T, Müller C, Plötz F, Rüther F, Scheper T, Schügerl K (1993) In: Alcock SJ, Turner APF. (eds) In-vivo chemical sensors. Cranfield, Bedford, UK, p 65

    Google Scholar 

  133. Menzel C, Beyer M, Kullick T, Quack R, Scheper T, Schügerl K (1993) Biol Ital 23:9

    Google Scholar 

  134. Scheper T, Brandes W, Maschke H, Plötz F, Müller C (1993) J Biotechnol 31:345

    Article  CAS  Google Scholar 

  135. Beyer M, Menzel C, Quack R, Scheper T, Schügerl K, Treichel W, Voigt H, Ullrich M, Ferretti R (1994) Biosens Bioelectron 9:17

    Article  CAS  Google Scholar 

  136. Kullick T, Ulber R, Meyer HH, Scheper T, Schügerl K (1994) Chem Eng Technol 66:704

    Google Scholar 

  137. Sevilla F, Kullick T, Scheper T (1994) Biosens Bioelectron 9:25

    Article  Google Scholar 

  138. Kullick T, Ulber R, Meyer HH, Scheper T, Schügerl K (1994) Anal Chim Acta 293:271

    Article  CAS  Google Scholar 

  139. Kullick T, Beyer M, Henning J, Lerch T, Quack R, Zeitz A, Hitzmann B, Scheper T, Schügerl K (1994) Anal Chim Acta 296:263

    Article  CAS  Google Scholar 

  140. Kullick T, Bock U, Schubert J, Scheper T, Schügerl K (1995) Anal Chim Acta 300:25

    Article  CAS  Google Scholar 

  141. Kullik T, Quack R, Röhrkasten C, Pekeler T, Scheper T (1995) Chem Eng Technol 18:225

    Article  Google Scholar 

  142. Menzel C, Lerch T, Scheper T, Schügerl K (1995) Anal Chim Acta 317:259

    Article  CAS  Google Scholar 

  143. Ulber R, Scheper T (1998) Methods Biotechnol 6:35

    CAS  Google Scholar 

  144. Selvanayagam ZE et al. (2002) Biosens Bioelectron 17:821

    Article  CAS  Google Scholar 

  145. Castellarnau M et al. (2007) Sens Actuators B 120:615

    Article  CAS  Google Scholar 

  146. Song KS et al. (2006) Phys Rev E 74:041919

    Article  CAS  Google Scholar 

  147. Wei JB et al. (2006) Rare Metal Mater Eng 35:443

    CAS  Google Scholar 

  148. Joo S, Brown RB (2008) Chem Rev 108:638

    Article  CAS  Google Scholar 

  149. Bergveld P (2003) Sens Actuators B 88:1

    Article  Google Scholar 

  150. Lorenzelli L et al. (2003) Biosens Bioelectron 18:621

    Article  CAS  Google Scholar 

  151. Maharbiz MM et al. (2004) Biotechnol Bioeng 85:376

    Article  CAS  Google Scholar 

  152. Oelssner W et al. (2005) Sens Actuators B 105:104

    Article  Google Scholar 

  153. Schoning MJ et al. (2005) Sens Actuators B 111:423

    Article  CAS  Google Scholar 

  154. Matsuo T, Esashi M (1981) Sens Actuators B 1:77

    Article  CAS  Google Scholar 

  155. Teravaninthorn U, Miyahara Y, Moriizumi T (1987) Jpn J Appl Phys 26:2116

    Article  CAS  Google Scholar 

  156. Simonis A et al. (2005) Electrochim Acta 51:930

    Article  CAS  Google Scholar 

  157. Kim HR et al. (2004) Sens Actuators B 97:348

    Article  CAS  Google Scholar 

  158. Simonis A et al. (2004) Sens Actuators B 103:429

    Article  CAS  Google Scholar 

  159. Matsuo T, Nakajima H (1984) Sens Actuators 5:293

    Article  CAS  Google Scholar 

  160. Vandenvlekkert HH et al. (1990) Sens Actuators B 1:395

    Article  Google Scholar 

  161. Chovelon JM et al. (1992) Sens Actuators B 8:221

    Article  Google Scholar 

  162. Sant W et al. (2003) Sens Actuators B 95:309

    Article  CAS  Google Scholar 

  163. Oelssner W et al. (2005) Sens Actuators B 105:104

    Article  Google Scholar 

  164. Schöning MJ, Brinkmann D, Rolka D, Demuth C, Poghossian A (2005) Sens Actuators B 111:423

    Article  CAS  Google Scholar 

  165. http://www.shl-unisensor.comAccessed 10 Mar 2008

  166. http://www.scilog.com/. Accessed 13 Apr 2008

  167. Henning B, Rautenberg J (2006) Ultrasonics 44:E1395

    Article  Google Scholar 

  168. Maa YF, Hsu CC (1999) Pharm Dev Technol 4:233

    Article  CAS  Google Scholar 

  169. Becker T, Mitzscherling M, Delgado A (2002) Food Control 13:223

    Article  Google Scholar 

  170. Khanal SK, Grewell D, Sung S, Hans van Leeuwen J (2007) Crit Rev Environ Sci Technol 37:277

    Article  CAS  Google Scholar 

  171. Schmidt P, Rosenfeld E, Millner R, Czerner R, Schellenberger A (1987) Biotechnol Bioeng 30:928

    Article  CAS  Google Scholar 

  172. Mohammad A, Khan AG, Kuek C (2000) Mycorhizza 9:337

    Article  Google Scholar 

  173. Hauptmann P, Hoppe N, Püttmer A (2002) Meas Sci Technol 13:R73

    Article  CAS  Google Scholar 

  174. Rama Rao M (1941) Nature 147:268

    Google Scholar 

  175. Püttmer A, Hoppe N, Henning B, Hauptmann P (1999) Sens Actuators A 76:122

    Article  Google Scholar 

  176. Schneditz D, Kenner T, Heimel H, Stabinger H (1989) J Acoust Soc Am 86:2073

    Article  Google Scholar 

  177. Brown LF, Mason JL (1996) IEEE Trans Ultrason Ferroelectr Freq Control 43:560

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Technical Chemistry, Leibniz University Hannover, Callinstr. 3, 30167, Hannover, Germany

    Anne Glindkamp, Daniel Riechers, Christoph Rehbock, Bernd Hitzmann & Thomas Scheper

  2. Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, 80523-1370, USA

    Kenneth F. Reardon

Authors
  1. Anne Glindkamp
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel Riechers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christoph Rehbock
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bernd Hitzmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Thomas Scheper
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kenneth F. Reardon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Scheper .

Editor information

Editors and Affiliations

  1. Hochschule Wädenswil, Wädenswil, Switzerland

    Regine Eibl

  2. Hochschule Wädenswil, Wädenswil, Switzerland

    Dieter Eibl

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Glindkamp, A., Riechers, D., Rehbock, C., Hitzmann, B., Scheper, T., Reardon, K.F. (2009). Sensors in Disposable Bioreactors Status and Trends. In: Eibl, R., Eibl, D. (eds) Disposable Bioreactors. Advances in Biochemical Engineering / Biotechnology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2009_10

Download citation

Publish with us

Policies and ethics

Search

Navigation