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N-Acetylaspartate pp 199–214Cite as

N-Acetyl-L-Aspartate in Multiple Sclerosis

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 576))

4. Conclusion

It is well established that axonal pathology is the basis of permanent disability in MS from its earliest stage. The promise of NAA measurement is that, it provides a specific and readily quantifiable index of neuronal and axonal dysfunction or loss. Therefore, monitoring NAA dynamics provides an index of change associated with irreversible stages in the evolution of diffuse MS lesions central to determining disability. Use in the proper context and together with other modern MR techniques, understanding NAA concentration dynamics may enable early forecast of disease course, reflect disease load and so influence treatment decision; improve clinical trial efficiency, and enhance further understanding of this complex disease.

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Authors and Affiliations

  1. Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, 44195

    Bruce D. Trapp

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  1. Gerson A. Criste
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Editors and Affiliations

  1. Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA

    John R. Moffett  & Aryan M. A. Namboodiri  & 

  2. University of Albany, Albany, NY, 12222, USA

    Suzannah B. Tieman

  3. National Institute of Mental Health, Bethesda, MD, 20814, USA

    Daniel R. Weinberger

  4. McLean Hospital, Belmont, MA, 02178, USA

    Joseph T. Coyle

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Criste, G.A., Trapp, B.D. (2006). N-Acetyl-L-Aspartate in Multiple Sclerosis. In: Moffett, J.R., Tieman, S.B., Weinberger, D.R., Coyle, J.T., Namboodiri, A.M.A. (eds) N-Acetylaspartate. Advances in Experimental Medicine and Biology, vol 576. Springer, Boston, MA . https://doi.org/10.1007/0-387-30172-0_14

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