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N-Acetylaspartate pp 175–182Cite as

Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?

A Tissue Culture Study of ASPA KO Mice Brain

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 576))

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4. References

  1. Tallan, H., 1957, Studies on the distribution of N-acetyl-L-aspartic acid in brain. J. Biol. Chem. 224:41.

    PubMed  CAS  Google Scholar 

  2. Miyake, M., Kakimoto, Y., and Sorimachi, M., 1980, A gas chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-aspartylglutamic acid and beta-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of animals. J. Neurochem. 36:804.

    Article  Google Scholar 

  3. Matalon, R., Michals, K., Sebesta, D., Deanching, M., Gashkoff, P., and Casanova, J., 1988, Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. Am. J. Med. Genet. 29:463.

    Article  PubMed  CAS  Google Scholar 

  4. Matalon, R., Kaul, R., Casanova, J., Michals, K., Johnson, A., Rapin, I., Gashkoff, P., and Deanching, M., 1989, Aspartoacylase deficiency: The enzyme defect in Canavan disease. Inher. Metab. Dis. 12:463.

    Google Scholar 

  5. D’Adamo, A.J., Smith, J., and Woiler, C., 1973, The occurrence of N-acetylaspartate amidohydrolase (aminoacylase II) in the developing rat. J. Neurochem. 20:1275.

    Article  PubMed  CAS  Google Scholar 

  6. Kaul, R., Casanova, J., Johnson, A., Tang, P., and Matalon, R., 1991, Purification, characterization, and localization of aspartoacylase from bovine brain. J. Neurochem. 56:129.

    Article  PubMed  CAS  Google Scholar 

  7. Baslow, M., Suckow, R., Sapirstein, V., and Hungund, B., 1999, Expression of aspartoacylase activity incultures rat macroglial cells is limited to oligodendrocytes. J. Mol. Neurosci. 13:47.

    Article  PubMed  CAS  Google Scholar 

  8. Bhakoo, K., and Pearce, D., 2000, In vitro expression of N-acetyl aspartate by oligodendrocytes: Implications for proton magnetic resonance spectroscopy signal in vivo. J. Neurochem. 74:254.

    Article  PubMed  CAS  Google Scholar 

  9. Madhavarao, C.N., Hammer, J.A., Quarles, R.H., Namboodiri, M.A., 2002, A radiometric assay for aspartoacylase activity in cultured oligodendrocytes. Anal. Biochem. 308:314.

    Article  PubMed  CAS  Google Scholar 

  10. Baslow, M., 2000, Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: Role in glial cell-specific signaling. J. Neurochem. 75:453–459.

    Article  PubMed  CAS  Google Scholar 

  11. Bhakoo, K., Craig, T., and Styles, P., 2001, Developmental and regional distribution of aspartoacylase in rat brain tissue. J. Neurochem. 79:211.

    Article  PubMed  CAS  Google Scholar 

  12. Chakraborty, G., Mekala, P., Yahya, D., Wu, G., and Ledeen, R., 2001, Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: Evidence for myelin-associated aspartoacylase. J. Neurochem. 78:736.

    Article  PubMed  CAS  Google Scholar 

  13. Chakraborty, G., Ledeen R., 2003, Fatty acid synthesizing enzymes intrinsic to myelin. Brain Res. Mol. Brain Res. 112:46.

    Article  PubMed  CAS  Google Scholar 

  14. Matalon, R., Rady, P., Platt, K., Skinner, H., Quast, M., Campbell, G., Matalon, K., Ceci, J., Tyring, S., Nehls, M., Surendran, S., Wei, J., Ezell, E., and Szucs, S., 2000, Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. J. Gene Med. 2:165.

    Article  PubMed  CAS  Google Scholar 

  15. Surendran, S., Michals-Matalon, K., Quast, M.J., Tyring, S.K., Wei, J., Ezell, E.L., Matalon, R., 2003, Canavan disease: a monogenic trait with complex genomic interaction. Mol. Genet. Metab. 80:74.

    Article  PubMed  CAS  Google Scholar 

  16. McCarthy, K., and de Vellis, J., 1980, Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85:879.

    Article  Google Scholar 

  17. Cole, R., and de Vellis, J., 1998, Preparation of astrocyte and oligodendrocyte cultures from primary rat glial cultures, in: A Dissection and Tissue Culture Manual of the Nervous System. Shahar, A., de Vellis, J., Vernadakis, A., and Haber, B., ed., Alan R. Liss, Inc. pp 121–133.

    Google Scholar 

  18. Lee, J., Mayer-Proschel, M., and Rao, M., 2000, Gliogenesis in the central nervous system. Glia 30:105.

    Article  PubMed  CAS  Google Scholar 

  19. Richardson, W.D., Smith, H.K., Sun, T., Pringle, N.P., Hall, A., and Woodruff, R., 2000, Oligodendrocyte lineage and the motor neuron connection. Glia 29:136.

    Article  PubMed  CAS  Google Scholar 

  20. Ellison, J., and de Vellis, J., 1994 Platelet-Derived growth factor receptor is expressed by cells in the early oligodendrocyte lineage. J. Neurosci. Res. 37, 116.

    Article  PubMed  CAS  Google Scholar 

  21. Ellison, J., Scully, S., and de Vellis, J., 1996, Evidence for Neuronal Regulation of Oligodendrocyte Development: Cellular Localization of Platelet-Derived Growth Factor Receptor and A-Chain mRNA During Cerebral Cortex Development in the Rat. J. Neurosci. Res. 44:28.

    Article  Google Scholar 

  22. Liu, Y., Rao, M.S., 2004, Glial progenitors in the CNS and possible lineage relationships among them. Biol. Cell 96:279.

    Article  PubMed  CAS  Google Scholar 

  23. Rogister, B., Ben Hur, T., and Dubois-Dalcq, M., 1999, From neural stem cells to myelinating oligodendrocytes. Mol. Cell. Neurosci. 14:287.

    Article  PubMed  CAS  Google Scholar 

  24. Aguirre, A., Gallo, V., 2004, Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone. J. Neurosci. 24:10530.

    Article  PubMed  CAS  Google Scholar 

  25. Kumar, S., and de Vellis, J., 1996, Neurotrophin activates signal transduction in oligodendroglial cells: expression of functional TrkC receptor isoforms. J. Neurosci. Res. 44:490.

    Article  PubMed  CAS  Google Scholar 

  26. Kumar, S., Kahn, M., Dinh, L., and de Vellis, J., 1998, NT-3-mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo. J. Neurosci.Res. 54:754.

    Article  PubMed  CAS  Google Scholar 

  27. Kahn, M., Kumar, S., Liebl, D., Chang, R., Parada, L., and de Vellis J. 1999 Mice lacking NT-3 and its Receptor TrkC exhibit profound deficiencies in CNS glial cells. Glia 26:153.

    Article  PubMed  CAS  Google Scholar 

  28. Hardy, R., and Reynolds, R., 1991, Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo. Development 111:1061.

    PubMed  CAS  Google Scholar 

  29. Monge, M., Kadiiski, D., Jacque, C.M., and Zalc, B., 1986, Oligodendroglial expression and deposition of four major myelin constituents in the myelin sheath during development. An in vivo study. Dev Neurosci. 8:222.

    PubMed  CAS  Google Scholar 

  30. Pfeiffer, S., Warrington, A., and Bansal, R., 1993, The OL and its many cellular processes. Trends Cell Biol. 3:191.

    Article  PubMed  CAS  Google Scholar 

  31. Gardinier, M., Amiguet, P., Linington, C., and Matthieu, J., 1992 Myelin/oligodendrocyte glydoprotein is a unique member of the immunoglobulin superfamily. J. Neurosci. Res. 33:177.

    Article  PubMed  CAS  Google Scholar 

  32. Kumar, S., Sachar, K., Huber, J., Weingarten, D.P., de Vellis, J., 1985, Glucocorticoids regulate the transcription of glycerol phosphate dehydrogenase in cultured glial cells. J. Biol. Chem. 260:14743.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Mental Retardation Research Center, Department of Neurobiology and Psychiatry, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles

    Jean de Vellis

  2. Division of Genetics, Department of Pediatrics, University of Texas Medical Branch, Galveston

    Sankar Surendran & Reuben Matalon

Authors
  1. Shalini Kumar
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  2. Rasika Sowmyalakshmi
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  3. Sarah L. Daniels
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  4. Ruth Chang
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  5. Sankar Surendran
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  6. Reuben Matalon
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  7. Jean de Vellis
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Editor information

Editors and Affiliations

  1. Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA

    John R. Moffett  & Aryan M. A. Namboodiri  & 

  2. University of Albany, Albany, NY, 12222, USA

    Suzannah B. Tieman

  3. National Institute of Mental Health, Bethesda, MD, 20814, USA

    Daniel R. Weinberger

  4. McLean Hospital, Belmont, MA, 02178, USA

    Joseph T. Coyle

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© 2006 Springer Science+Business Media, Inc.

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Kumar, S. et al. (2006). Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?. In: Moffett, J.R., Tieman, S.B., Weinberger, D.R., Coyle, J.T., Namboodiri, A.M.A. (eds) N-Acetylaspartate. Advances in Experimental Medicine and Biology, vol 576. Springer, Boston, MA . https://doi.org/10.1007/0-387-30172-0_12

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