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Is Cycloxygenase-2 (COX-2) a Major Component of the Mechanism Responsible for Microvascular Remodeling in the Brain?

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Oxygen Transport to Tissue XXVII

Part of the book series: Advances in Experimental Medicine and Biology ((volume 578))

5. Conclusion

We have used a relatively simple model of hypoxia that triggers adaptive structural changes in the cerebral microvasculature to study the process of physiological angiogenesis. This model can be used to obtain mechanistic data for the processes that probably underlie the dynamic structural changes that occur in learning and the control of oxygen availability to the neurovascular unit. These mechanisms are broadly involved in a wide variety of pathophysiological processes. This is the vascular component to CNS functional plasticity, supporting learning and adaptation. The angiogenic process may wane with age, contributing to the decreasing ability to survive metabolic stress and the diminution of neuronal plasticity.

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Author information

Authors and Affiliations

  1. Department of Anatomy, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106

    Nicole L. Ward

Authors
  1. Joseph C. LaManna
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  2. Xiaoyan Sun
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  3. Andre D. Ivy
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  4. Nicole L. Ward
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Editor information

Editors and Affiliations

  1. C.E.M.O.T.—Centro Interdipantimentale di Ricerca in Emoreologia, Microcircolazione, Transporto di Ossigeno e Tecnologie Ottiche non Invasive, Università di Bari, Bari, Italy, 70124

    Giuseppe Cicco

  2. College of Engineering, University of Maryland Baltimore County, Baltimore, MD, 21250, USA

    Duane F. Bruley

  3. Dip. Di Scienze e Tecnologie Biomediche, Università de L’Aquila, L’Aquila, Italy, 67100

    Marco Ferrari

  4. Regional Medical Physics Department, University Hospital of North Durham, Durham, UK, DH1 5TW

    David K. Harrison

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LaManna, J.C., Sun, X., Ivy, A.D., Ward, N.L. (2006). Is Cycloxygenase-2 (COX-2) a Major Component of the Mechanism Responsible for Microvascular Remodeling in the Brain?. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_47

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