Abstract
The location, identity and functional properties of the primary molecular components of the NO/cGMP pathway have now been well-characterised. These components are widespread, but not ubiquitous, across the brain, and the downstream effects of activation of this pathway are diverse and often incompletely understood. It is now important to consider the identity of these later stages of the transduction pathway and the way in which different dynamic patterns of NO and cGMP signalling induce such a variety of change in the long- and short-term function of neuronal circuitry. Future studies need to concentrate on the effects of endogenously-released NO and on the application of concentrations of exogenous NO that are physiologically relevant, in order to dissect out the downstream targets of NO signalling that relate to normal function.
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Hall, C.N., Garthwaite, J. (2005). Trans-Synaptic Signalling by Nitric Oxide. In: Ludwig, M. (eds) Dendritic Neurotransmitter Release. Springer, Boston, MA. https://doi.org/10.1007/0-387-23696-1_19
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