Conclusion
Very low levels of MBL were detected in a significantly higher number of BD patients compared to HC, ROU and RA. This observation needs to be confirmed with genetic analysis as low MBL levels are shown to correlate with MBL gene mutations.
These results suggest that MBL deficiency might contribute to the pathogenesis of BD by impairing “innate” immune responses against microorganisms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sakane, T., Takeno, M., Suzuki, N., et al., 1999, Behçet’s disease. N. Engl. J. Med. 341: 1284–1291.
Direskeneli, H., 2001, Behçet’s disease: infectious aetiology, new autoantigens, and HLA-B5l. Ann. Rheum. Dis. 60: 996–1002.
Gadjeva, M., Thiel, S., and Jensenius, J.C., 2001, The mannan-binding-lectin pathway of the innate immune response. Curr. Opin. Immunol. 13: 74–78.
Turner, W.T., 1996, Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol. Today 17: 532–540.
Graudal, N.A., Homann, C., and Madsen, H.O., 1998, Mannan binding lectin in rheumatoid arthritis. A longitudinal study. J. Rheumatol. 25: 629–635.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Kluwer Academic Publishers
About this chapter
Cite this chapter
Inanc, N., Birtas, E., Yavuz, S., Ergun, T., Direskeneli, H. (2004). Low Serum Mannose-binding Lectin Levels in Behçet’s Disease. In: Zouboulis, C.C. (eds) Adamantiades-Behçet’s Disease. Advances in Experimental Medicine and Biology, vol 528. Springer, Boston, MA. https://doi.org/10.1007/0-306-48382-3_58
Download citation
DOI: https://doi.org/10.1007/0-306-48382-3_58
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-47757-7
Online ISBN: 978-0-306-48382-0
eBook Packages: Springer Book Archive