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Growth hormone insensitivity: diagnostic and therapeutic approaches

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Abstract

Introduction

Growth hormone resistance defines several genetic (primary) and acquired (secondary) pathologies that result in completely or partially interrupted activity of growth hormone. An archetypal disease of this group is the Laron-type dwarfism caused by mutations in growth hormone receptors. The diagnosis is based on high basal levels of growth hormone, low insulin like growth factor-I (IGF-1) level, unresponsiveness to IGF generation test and genetic testing. Recombinant IGF-1 preparations are used in the treatment

Conclusion

In this article, clinical characteristics, diagnosis and therapeutic approaches of the genetic and other diseases leading to growth hormone insensitivity are reviewed.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric Endocrinology, Medical Faculty, Erciyes University, 38039, Kayseri, Turkey

    S. Kurtoğlu & N. Hatipoglu

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  1. S. Kurtoğlu
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  2. N. Hatipoglu
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Correspondence to N. Hatipoglu.

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Kurtoğlu, S., Hatipoglu, N. Growth hormone insensitivity: diagnostic and therapeutic approaches. J Endocrinol Invest 39, 19–28 (2016). https://doi.org/10.1007/s40618-015-0327-2

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  • DOI: https://doi.org/10.1007/s40618-015-0327-2

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