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Failure of Trimethoprim/Sulfamethoxazole Prophylaxis for Pneumocystis carinii Pneumonia with Concurrent Leucovorin Use

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Abstract

Pneumocystis carinii is a common cause of pneumonia in patients with AIDS, however, the incidence has dropped with the availability of effective prophylactic regimens. First-line treatment for both acute Pneumocystis pneumonia and chronic prophylaxis is trimethoprim/sulfamethoxazole (TMP/SMX). This combination can cause hypersensitivity reactions as well as myelosuppression. The simultaneous administration of leucovorin during acute treatment has bee shown to reduce the incidence of neutropenia, but may interfere with the efficacy of TMP/SMX. We report a case of P. carinii pneumonia in a patient with AIDS who failed TMP/SMX prophylaxis while taking leucovorin.

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Authors and Affiliations

  1. Dept. of Medicine, Washington University School of Medicine, St. Louis, MO, USA, , , , , , US

    B. Razavi

  2. University of Iowa College of Pharmacy, Iowa Citiy, IA, USA, , , , , , US

    B. Lund

  3. Dept. of Internal Medicine, Indianapolis VAMC and Indiana University School of Medicine, Division of Infectious Diseases, EH 435,545 Barnhill Drive, Indianapolis, IN 46202, USA; Phone: (317) 274-2898, Fax: -1587, e-mail: bradalle@iupui.edu, , , , , , US

    B. L. Allen

  4. Dept. of Internal Medicine, Iowa City VAMC and University of Iowa Hospitals and Clinicx, Iowa City, IA, USA, , , , , , US

    L. Schlesinger

Authors
  1. B. Razavi
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  2. B. Lund
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  3. B. L. Allen
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  4. L. Schlesinger
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Received: October 25, 2000 · Revision accepted: October 4, 2001

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Razavi, B., Lund, B., Allen, B. et al. Failure of Trimethoprim/Sulfamethoxazole Prophylaxis for Pneumocystis carinii Pneumonia with Concurrent Leucovorin Use. Infection 30, 41–42 (2002). https://doi.org/10.1007/s15010-001-1172-0

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  • DOI: https://doi.org/10.1007/s15010-001-1172-0

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