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JDP2 inhibits the epithelial-to-mesenchymal transition in pancreatic cancer BxPC3 cells

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Tumor Biology

Abstract

Pancreatic carcinoma is one of the most malignant and aggressive cancers. Increased motility and invasiveness of pancreatic cancer cells are believed to be associated with epithelial-to-mesenchymal transition (EMT). However, the molecular basis of EMT in pancreatic cancer cells is poorly understood. In this study, we examined the relationship between Jun dimerization protein 2 (JDP2), which is an AP-1 inhibitor, and EMT in human pancreatic carcinoma cells. We demonstrated that transforming growth factor-β1 (TGF-β1) promoted epidermal growth factor (EGF)-induced EMT in co-treated human pancreatic BxPC3 cells and that JDP2 overexpression reversed the EMT that was induced by co-treatment with TGF-β1 and EGF. These results suggest that EGF plays a principal role in EMT through its association with TGF-β1 in human pancreatic BxPC3 cells and that JDP2 may be a molecular target for pancreatic carcinoma intervention.

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Authors and Affiliations

  1. Department of Pancreatic Gastroenterologic Surgery, First Hospital of China Medical University, No. 92, Nanjing Rd, Shenyang, 110001, China

    Zhe Liu, Jin Long, Anbing Dong, Jianpeng Fan, Kejian Guo & Yuanhong Xu

  2. Department of Otorhinolaryngology, Fengtian Hospital, Shenyang Medical University, Shenyang, China

    Ruixia Du

Authors
  1. Zhe Liu
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  2. Ruixia Du
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  3. Jin Long
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  4. Anbing Dong
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  5. Jianpeng Fan
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  6. Kejian Guo
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  7. Yuanhong Xu
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Correspondence to Kejian Guo or Yuanhong Xu.

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Liu, Z., Du, R., Long, J. et al. JDP2 inhibits the epithelial-to-mesenchymal transition in pancreatic cancer BxPC3 cells. Tumor Biol. 33, 1527–1534 (2012). https://doi.org/10.1007/s13277-012-0404-5

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  • DOI: https://doi.org/10.1007/s13277-012-0404-5

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