Skip to main content

Advertisement

Log in

Can We Really Prevent Suicide?

  • Mood Disorders (SM Strakowski, Section Editor)
  • Published:
Current Psychiatry Reports Aims and scope Submit manuscript

Abstract

Every year, suicide is among the top 20 leading causes of death globally for all ages. Unfortunately, suicide is difficult to prevent, in large part because the prevalence of risk factors is high among the general population. In this review, clinical and psychological risk factors are examined and methods for suicide prevention are discussed. Prevention strategies found to be effective in suicide prevention include means restriction, responsible media coverage, and general public education, as well identification methods such as screening, gatekeeper training, and primary care physician education. Although the treatment for preventing suicide is difficult, follow-up that includes pharmacotherapy, psychotherapy, or both may be useful. However, prevention methods cannot be restricted to the individual. Community, social, and policy interventions will also be essential.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. http://www.who.int/topics/suicide/en/

  2. WHO mortality database. http:/www.who.int/healthinfo/morttables/en/.

  3. Wasserman D, Rihmer Z, Rujescu D, Sarchiapone M, Sokolowski M, Titelman D, Zalsman G, Zemishlany Z, Carli V. European psychiatric association Guidance on Suicide treatment and Prevention. Eur Psychiatry. 2012;27(2):129–41.

    Article  PubMed  CAS  Google Scholar 

  4. Posner K, Oquendo MA, Gould M, Stanley B, Davies M. Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants. Am J Psychiatry. 2007;164(7):1035–43.

    Article  PubMed  Google Scholar 

  5. Pompili M, Rihmer Z, Innamorati M, Lester D, Girardi P, Tatarelli R. Assessment and treatment of suicide risk in bipolar disorders. Expert Rev Neurother. 2009;9(1):109–36.

    Article  PubMed  Google Scholar 

  6. Soloff PH, Fabio A. Prospective predictors of suicide attempts in borderline personality disorder. J Pers Disord. 2008;22(2):123–34.

    Article  PubMed  Google Scholar 

  7. Soloff PH, Fabio A, Lonnqvist J. Major psychiatric disorders in suicide and suicide attempters. In: Wasserman D, Wasserman C, editors. Oxford textbook of suicidology and suicide prevention: a global perspective. Oxford: Oxford University Press; 2009. p. 275–86.

    Google Scholar 

  8. Rihmer Z. Suicide risk in mood disorders. Curr Opin Psychiatry. 2007;20:17–22.

    Article  PubMed  Google Scholar 

  9. Mann JJ, Ellis SP, Waternaux CM, Liu X, Oquendo MA, Malone KM, Brodsky BS, Haas GL, Currier D. Classification trees distinguish suicide attempters in major psychiatric disorders: a model of clinical decision making. J Clin Psychiatry. 2008;69(1):23–31.

    Article  PubMed  Google Scholar 

  10. Mann JJ, Apter A, Bertolote J, Beautrais A, Currier D, Haas A, Hegerl U, Lonnqvist J, Malone K, Marusic A, Mehlum L, Patton G, Phillips M, Rutz W, Rihmer Z, Schmidtke A, Shaffer D, Silverman M, Takahashi Y, Varnik A, Wasserman D, Yip P, Hendin H. Suicide prevention strategies: a systematic review. JAMA. 2005;294:2064–74.

    Article  PubMed  CAS  Google Scholar 

  11. Luoma JB, Martin CE, Pearson JL. Contact with mental health and primary care providers before suicide: a review of the evidence. Am J Psychiatry. 2002;159:909–16.

    Article  PubMed  Google Scholar 

  12. Andersen UA, Andersen M, Rosholm JU, Gram LF. Contacts to the health care system prior to suicide: a comprehensive analysis using registers for general and psychiatric hospital admissions, contacts to general practitioners and practicing specialists and drug prescriptions. Acta Psychiatr Scand. 2000;102:126–34.

    Article  PubMed  CAS  Google Scholar 

  13. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors: systematic analysis of population health data. Lancet. 2006;367:1747–57.

    Article  PubMed  Google Scholar 

  14. Isacsson G, Holmgren P, Druid H, Bergman U. The utilization of antidepressants-a key issue in the prevention of suicide: an analysis of 5281 suicides in Sweden during the period 1992–1994. Acta Psychiatr Scand. 1997;96:94–100.

    Article  PubMed  CAS  Google Scholar 

  15. Isacsson G, Holmgren P, Wasserman D, Bergman U. Use of antidepressants among people committing suicide in Sweden. BMJ. 1994;308:506–9.

    Article  PubMed  CAS  Google Scholar 

  16. Oquendo MA, Currier D, Mann JJ. Prospective studies of suicidal behavior in major depressive and bipolar disorders: what is the evidence for predictive risk factors? Acta Psychiatr Scand. 2006;114:151–8.

    Article  PubMed  CAS  Google Scholar 

  17. • Lonnqvist J. Major Psychiatric disorders in suicide and suicide attempts. In: Wasserman D, Wasserman C, editors. Oxford textbook of suicidology and suicide prevention: a global perspective. Oxford: Oxford University Press; 2009. p. 275–86. This systematic review of disorders that serve as risk factors for both suicide and suicide attempts provides a comprehensive summary of the literature to date.

    Google Scholar 

  18. Boden JM, Fergusson DM, Horwood LJ. Anxiety disorders and suicidal behaviours in adolescence and young adulthood: findings from a longitudinal study. Psychol Med. 2007;37:431–40.

    Article  PubMed  Google Scholar 

  19. Fawcet J, Scheftner WA, Fogg L, Clark DC, Young MA, Hedeker D, Gibbons R. Time relared predictors of suicide in major affective disorders. Am J Psychiatry. 1990;147:1189–94.

    Google Scholar 

  20. Johnson J, Weissman M, Klerman GL. Panic disorder, comorbidity, and suicide attempts. Arch Gen Psychiatry. 1990;47:805–8.

    Article  PubMed  CAS  Google Scholar 

  21. Placidi PG. Anxiety in major depression: relationship to suicide attempts. Am J Psychiatry. 2000;157(10):1614–8.

    Article  PubMed  CAS  Google Scholar 

  22. Panagioti M, Gooding P, Tarrier N. Post-traumatic stress disorder and suicidal behavior: a narrative review. Clin Psychol Rev. 2009;29:471–82.

    Article  PubMed  Google Scholar 

  23. Pirkola SP, Isometsa ET, Heikkinen ME, Lonnqvist JK. Suicides of alcohol misusers and non-misusers in a nationwide population. Alcohol Alcohol. 2000;35:70–5.

    PubMed  CAS  Google Scholar 

  24. Oquendo MA, Currier D, Liu S, Hasin D, Grant B, Blanco C. Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders. J Clin Psychiatry. 2010;71(7):902–9.

    Article  PubMed  Google Scholar 

  25. Bushe C, Taylor M, Haukka J. Mortality in schizophrenia – A measurable clinical endpoint. J Psychopharmacol. 2010;24(4):17–25.

    Article  PubMed  Google Scholar 

  26. Palmer BA, Pankratz VS, Bostwick JM. The lifetime risk of suicide in schizophrenia: a reexamination. Arch Gen Psychiatry. 2005;62:247–53.

    Article  PubMed  Google Scholar 

  27. Haw C, Hawten K, Sutton L, Sinclair J, Deeks J. Schizophrenia and deliberate self harm: a systematic review of risk factors. Suicide Life Threat Behav. 2005;35:50–62.

    Article  PubMed  Google Scholar 

  28. Hor K, Taylor M. Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol. 2010;24(4):81–90.

    Article  PubMed  Google Scholar 

  29. Stanely B, Jones J. Risk for suicidal behavior in personality disorders. In: Wasserman D, Wasserman C, editors. Oxford textbook of suicidology and suicide prevention: a global perspective. Oxford: Oxford University Press; 2009. p. 287–92.

    Google Scholar 

  30. Chioqueta AP, Stiles TC. Assessing suicide risk in cluster C personality disorders. Crisis. 2004;25:128–33.

    Article  PubMed  Google Scholar 

  31. Schneider B, Watterling T, Sargk D, Schneider F, Schnabel A, Maurer K, Fritze J. Axis one disorders and personality disorders as risk factors for suicide. Eur Arch Psychiatry Clin Neurosci. 2006;256:17–27.

    Article  PubMed  Google Scholar 

  32. Sabo AN, Gunderson JG, Najavits LM, Chauncey D, Kisiel C. Changes in self-destructiveness of borderline patients in psychotherapy. A prospective follow-up. J Nerv Ment Dis. 1995;183:370–6.

    Article  PubMed  CAS  Google Scholar 

  33. Malone KM, Haas GL, Sweeney JA, Mann JJ. Major depression and the risk of attempted suicide. J Affect Disord. 1995;34(3):173–l85.

    Article  PubMed  CAS  Google Scholar 

  34. Oquendo MA, Waternaux C, Brodsky B, Parsons B, Haas GL, Malone KM, Mann JJ. Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and nonattempters. J Affect Disord. 2000;59:107–17.

    Article  PubMed  CAS  Google Scholar 

  35. Maser JD, Akiskal HS, Schettler P, Scheftner W, Mueller T, Endicott J, Solomon D, Clayton P. Can temperament identify affectively ill patients who engage in lethal or near-lethal suicidal behavior? a 14-year prospective study. Suicide Life Threat Behav. 2002;32:10–32.

    Article  PubMed  Google Scholar 

  36. Schneider B, Philipp M, Muller MJ. Psychopathological predictors of suicide in patients with major depression during a 5-year follow-up. Eur Psychiatry. 2001;16:283–8.

    Article  PubMed  CAS  Google Scholar 

  37. Keller F, Wolfersdorf M. Hopelessness and the tendency to commit suicide in the course of depressive disorders. Crisis. 1993;14:173–7.

    PubMed  CAS  Google Scholar 

  38. Sidley GL, Calam R, Wells A, Hughes T, Whitaker K. The prediction of parasuicide repetition in a high-risk group. Br J Clin Psychol. 1999;38:375–86.

    Article  PubMed  Google Scholar 

  39. Brent DA, Mann JJ. Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet. 2005;133C:13–24.

    Article  PubMed  Google Scholar 

  40. Roy A, Janal M. Family history of suicide, female sex, and childhood trauma: separate or interacting risk factors for attempts at suicide? Acta Psychiatr Scand. 2005;112:367–71.

    Article  PubMed  CAS  Google Scholar 

  41. Roy A, Nielson D, Rylander G, Sarchiapone M. The genetics of suicidal behavior. In: Hawton K, van Heeringen K, editors. The international handbook of suicide and attempted suicide. Wiley: Chichester; 2000. p. 209–22.

    Chapter  Google Scholar 

  42. Egeland JA, Sussex JN. Suicide and family loading for affective disorders. JAMA. 1985;254(7):915–8.

    Article  PubMed  CAS  Google Scholar 

  43. Brent DA, Oquendo M, Birmaher B, Greenhill L, Kolko D, Stanley B, Zelazny J, Brodsky B, Bridge J, Ellis S, Salazar JO, Mann JJ. Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters. Arch Gen Psychiatry. 2002;59(9):801–7.

    Article  PubMed  Google Scholar 

  44. Brent DA. Peripubertal suicide attempts in offspring of suicide attempters with siblings concordant for suicidal behavior. Am J Psychiatry. 2003;160(8):1486–93.

    Article  PubMed  Google Scholar 

  45. Melhem NM. Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior. Am J Psychiatry. 2007;164(9):1364–70.

    Article  PubMed  Google Scholar 

  46. Cassidy F. Risk factors of attempted suicide in bipolar disorder. Suicide Life-Threat Behav. 2011;41:6–11.

    Article  PubMed  Google Scholar 

  47. Goodwin FK, Fireman B, Simon GE, Hunkeler EM, Lee J, Revicki D. Suicide risk in bipolar disorder during treatment with lithium and divalproex. JAMA. 2003;290:1467–73.

    Article  PubMed  CAS  Google Scholar 

  48. Harris EC, Barraclough B. Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry. 1997;170:205–28.

    Article  PubMed  CAS  Google Scholar 

  49. Hawton K, Sutton L, Haw C, Sinclair J, Harriss L. Suicide and attempted suicide in bipolar disorder: a systematic review of risk factors. J Clin Psychiatry. 2005;66:693–704.

    Article  PubMed  Google Scholar 

  50. Rihmer Z. Pharmacological prevention of suicide in bipolar patients – a realizable target. J Affect Disord. 2007;103:1–3.

    Article  PubMed  Google Scholar 

  51. Rihmer Z. Suicide risk in mood disorders. Curr Opin Psychiatry. 2007;20:17–22.

    Article  PubMed  Google Scholar 

  52. Rihmer Z, Kiss K. Bipolar disorders and suicidal behaviour. Bipolar disorder. 2002;4(1):21–5.

    Article  Google Scholar 

  53. Leon AC, Keller MB, Warshaw MG, Mueller TI, Solomon DA, Coryell W, Endicott J. A prospective study of fluoxetine treatment and suicidal behavior in affectively ill subjects. Am J Psychiatry. 1999;156:195–201.

    PubMed  CAS  Google Scholar 

  54. Oquendo MA, Kamali M, Ellis SP, Grunebaum MF, Malone KM, Brodsky BS, Sackeim HA, Mann JJ. Adequacy of antidepressant treatment after discharge and the occurrence of suicidal acts in major depression: a prospective study. Am J Psychiatry. 2002;159:1746–51.

    Article  PubMed  Google Scholar 

  55. Valtonen H, Suominen K, Mantere O, et al. Suicidal ideation and attempts in bipolar I and bipolar II disorders. J Clin Psychiatry. 2005;66:1456–62.

    Article  PubMed  Google Scholar 

  56. Coryell W, Young EA. Clinical predictors of suicide in primary major depressive disorder. J Clin Psychiatry. 2005;66:412–7.

    Article  PubMed  Google Scholar 

  57. Hayes LM. Juvenile suicide in confinement in the United States: results from a National Survey. Crisis. 2005;26:146–8.

    Article  PubMed  Google Scholar 

  58. Williams JMG, Crane C, Van der Does AJW, Segal ZV. Recurrence of suicidal ideation across depressive episodes. J Affect Disord. 2005;91:189–94.

    Article  Google Scholar 

  59. Galfalvy H, Oquendo MA, Carballo JJ, Sher L, Grunebaum MF, Burke A, Mann JJ. Clinical predictors of suicidal acts after major depression in bipolar disorder: a prospective study. Bipolar Disord. 2006;8:586–95.

    Article  PubMed  Google Scholar 

  60. Fagiolini A, Kupfer DJ, Rucci P, Scott JA, Novick DM, Frank E. Suicide attempts and ideation in patients with bipolar I disorder. J Clin Psychiatry. 2004;65:509–14.

    Article  PubMed  Google Scholar 

  61. Hegerl U, Wittmann M, Arensman E, Van Audenhove C, Bouleau JH, Van Der Feltz-Cornelis C, Gusmao R, Kopp M, Lohr C, Maxwell M. The ‘European Alliance Against Depression (EAAD)’: a multifaceted, community-based action programme against depression and suicidality. World J Biol Psychiatry. 2008;9:51–8.

    Article  PubMed  Google Scholar 

  62. U.S. Suicide Statistics (2005) http://www.suicide.org/suicide-statistics

  63. Beautrais A, Fergusson D, Coggan C, Collings C, Doughty C, Ellis P, Hatcher S, Horwood J, Merry S, Mulder R, Poulton R, Surgenor L. Effective strategies for suicide prevention in New Zealand:a review of the evidence. The new Zealand journal of medicine 2007;120.

  64. Bridges FS, Kunselman JC. Gun availability and use of guns for suicide, homicide, and murder in Canada. Percept Mot Skills. 2004;98:594–8.

    Article  PubMed  Google Scholar 

  65. Miller M, Azrael D, Hepburn L, Hemenway D, Lippmann SJ. The association between changes in household firearm ownership and rates of suicide in the United States, 1981–2002. Inj Prev. 2006;12:178–82.

    Article  PubMed  CAS  Google Scholar 

  66. Kapusta ND, Etzersdorfer E, Krall C, Sonneck G. Firearm legislation reform in the European Union: impact on firearm availability, firearm suicide and homicide rates in Austria. Br J Psychiatry. 2007;191:253–7.

    Article  PubMed  Google Scholar 

  67. Shelef M. Unanticipated benefits of automotive emission control: reduction in fatalities by motor vehicle exhaust gas. Sci Total Environ. 1994;146–147:93–101.

    Article  PubMed  Google Scholar 

  68. Kelly S, Bunting J. Trends in suicide in England and Wales, 1982–96. Popul Trends. 1998;92:29–41.

    PubMed  Google Scholar 

  69. Bennewith O, Nowers M, Gunnell D. Suicidal behaviour and suicide from the Clifton Suspension Bridge, Bristol and surrounding area in the UK: 1994–2003. Eur J Public Health. 2011;21:204–8.

    Article  PubMed  Google Scholar 

  70. Lin JJ, Lu TH. Association between the accessibility to lethal methods and method-specific suicide rates: an ecological study in Taiwan. J Clin Psychiatry. 2006;67:1074–9.

    Article  PubMed  Google Scholar 

  71. Gunnell D, Bennewith O, Hawton K, Simkin S, Kapur N. The epidemiology and prevention of suicide by hanging: a systematic review. Int J Epidemiol. 2005;34:433–42.

    Article  PubMed  Google Scholar 

  72. Sarchiapone M, Mandelli L, Iosue M, Andrisano C, Roy A. Controlling access to suicide means. Int J Environ Res Public Health. 2011;8:4550–62.

    Article  PubMed  Google Scholar 

  73. Tsai CW, Gunnell D, Chou YH, Kuo CJ, Lee MB, Chen YY. Why do people choose charcoal burning as a method of suicide? An interview based study of survivors in Taiwan. J Affect Disord. 2011;131:402–7.

    Article  PubMed  Google Scholar 

  74. Sonneck G, Etzersdorfer E, Nagel-Kuess S. Imitative suicide on the Viennese subway. Soc Sci Med. 1994;38:453–7.

    Article  PubMed  CAS  Google Scholar 

  75. •• van der Feltz-Cornelis CM, Sarchiapone M, Postuvan V, Volker D, Roskar S, Grum AT, Carli V, McDaid D, O'Connor R, Maxwell M, Ibelshäuser A, Van Audenhove C, Scheerder G, Sisask M, Gusmão R, Hegerl U. Best practice elements of multilevel suicide prevention strategies: a review of systematic reviews. Crisis. 2011;32(6):319–33. This concise meta-review summarizes the data relevant to designing a comprehensive suicide prevention model, addressing the various levels of intervention that are essential to an effective campaign.

    Article  PubMed  Google Scholar 

  76. Knox KL, Litts DA, Talcott WJ, Catalano Feig J, Caine ED. Risk of suicide and related adverse outcomes after exposure to a suicide prevention programme in the US Air Force: cohort study. BMJ. 2003;327:1376–8.

    Article  PubMed  Google Scholar 

  77. Hegerl U, Althaus D, Stefanek J. Public attitudes towards treatment of depression: effects of an information campaign. Pharmacopsychiatry. 2003;36:288–91.

    Article  PubMed  CAS  Google Scholar 

  78. Jorm AF, Christensen H, Griffiths KM. The impact of beyondblue: the national depression initiative on the Australian public’s recognition of depression and beliefs about treatments. Aust NZJ Psychiatry. 2005;39:248–54.

    Google Scholar 

  79. Akroyd S, Wyllie J. Impacts of National Media Campaign to Counter Stigma and Discrimination Associated with Mental Illness: Survey 4. Wellington, New Zealand: New Zealand Ministry of Health; 2002. Publication 9-20-0004.

  80. • Dumesnil H, Verger P. Public awareness campaigns about depression and suicide: a review. Psychiatr Serv. 2009;60:1203–13. The role of policy in public health and suicide prevention in particular is highlighted in this review of the evidence.

    Article  PubMed  Google Scholar 

  81. Hegerl U, Althaus D, Schmidtke A, Niklewski G. The alliance against depression: 2-year evaluation of a community-based intervention to reduce suicidality. Psychol Med. 2006;36:1225–33.

    Article  PubMed  Google Scholar 

  82. Leitner M, Barr W, Hobby L. Effectiveness of interventions to prevent suicide and suicidal behavior: a systematic review. Edinburgh, UK: Scottish Government Social Research; 2008.

    Google Scholar 

  83. Szanto K, Kalmar S, Hendin H, Rihmer Z, Mann JJ. A suicide prevention program in a region with a very high suicide rate. Arch Gen Psychiatry. 2007;64:914–20.

    Article  PubMed  Google Scholar 

  84. Mehlum L, Schwebs R. Suicide prevention in the military: recent experiences in the Norwegian army. In: Program and abstracts of the 33rd International Congress on Military Medicine; June 25–30, 2000; Helsinki, Finland.

  85. Wyman PA, Brown CH, Inman J, Cross W, Schmeelk-Cone K, Guo J, Pena JB. Randomized trial of a gatekeeper program for suicide prevention: 1-year impact on secondary school staff 2008. J Consult Clin Psychol. 2008;76(1):104–15.

    Article  PubMed  Google Scholar 

  86. Shaffer D, Scott M, Wilcox H, Maslow C, Hicks R, Lucas CP, Garfinkel R, Greenwald S. The Columbia Suicide Screen: validity and reliability of a screen for youth suicide and depression. J Am Acad Child Adolesc Psychiatry. 2004;43:71–9.

    Article  PubMed  Google Scholar 

  87. Pignone MP, Gaynes BN, Rushton JL, Burchell CM, Orleans CT, Mulrow CD, Lohr KN. Screening for depression in adults: a summary of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2002;136:765–76.

    PubMed  Google Scholar 

  88. Gaynes BN, West SL, Ford CA, Frame P, Klein J, Lohr KN. Screening for suicide risk in adults: a summary of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2004;140:822–35.

    PubMed  Google Scholar 

  89. http://www.who.int/mental_health/management/depression/definition/en

  90. Stanley B, Brown G, Brent DA, et al. Cognitive-behavioral therapy for suicide prevention (CBT-SP): treatment model, feasibility, and acceptability. J Am Acad Child Adolesc Psychiatry. 2009;48:1005–13.

    Article  PubMed  Google Scholar 

  91. Rudd MD, Williams B, Trotter D. The psychological and behavioural treatment of suicidal behaviour: what are the common elements of treatment that work? In: Wasserman D, Wasserman C, editors. Oxford textbook of suicidology and suicide prevention: a global perspective. Oxford: Oxford University Press; 2009. p. 427–37.

    Google Scholar 

  92. Tarrier N, Taylor K, Gooding P. Cognitive-behavioral interventions to reduce suicide behavior a systematic review and meta-analysis. Behav Modif. 2008;32:77–108.

    Article  PubMed  Google Scholar 

  93. Brown GK, Ten Have TR, Henriques GR, Xie SX, Hollander JE, Beck AT. Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial. JAMA. 2005;294:563–70.

    Article  PubMed  CAS  Google Scholar 

  94. Cognitive treatment of suicidal adults In: Wasserman D, Wasserman C, editors. Oxford Textbook of Suicidology and Suicide Prevention: a Global Perspective. Oxford: Oxford University Press; 2009. p. 413–420.

  95. DBT for suicidal individuals in: Wasserman D, Wasserman C, editors. Oxford Textbook of Suicidology and Suicide Prevention: a Global Perspective. Oxford: Oxford University Press; 2009. p. 421–425.

  96. Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, Korslund KE, Tutek DA, Reynolds SK, Lindenboim N. Two-year randomized controlled trial and follow-up of dialectical behavior therapy vs therapy by experts for suicidal behaviors and borderline personality disorder. Arch Gen Psychiatry. 2006;63:757.

    Article  PubMed  Google Scholar 

  97. Bauer M, Bschor T, Pfenning A, Whybrow PC, Angst J, Versiani M, Möller HJ. World Federation of Societies of Biological Psychiatry (WFSBP) guiedelines for Biological Treatment of Unipolar Depressive Disorders in primary care. World J Biol Psychiatry. 2007;8:67–104.

    Article  PubMed  Google Scholar 

  98. Bauer M, Whybrow PC, Angst J, Versiani M, Möller HJ. World Federation Of Societies Of Biological Psychiatry (WFSBP) guiedelines for Biological Treatment of Unipolar Depressive Disorders, part 1: acute and continuation treatment of major depressive disorder. World J Biol Psychiatry. 2002;3:5–43.

    Article  PubMed  Google Scholar 

  99. Gibbons RD, Hur K, Bhaumik DK, Mann JJ. The relationship between antidepressant medication use and rate of suicide. Arch Gen Psychiatry. 2005;65:165–72.

    Article  Google Scholar 

  100. Olfson M, Shaffer D, Marcus SC, Greenberg T. Relationship between antidepressant medication treatment and suicide in adolescents. Arch Gen Psychiatry. 2003;60:978–82.

    PubMed  Google Scholar 

  101. Hall WD, Mant A, Mitchell PB, Rendle VA, Hickie IB, McManus P. Association between antidepressant prescribing and suicide in Australia, 1991–2000: trend analysis. BMJ. 2003;326:1008.

    Article  PubMed  Google Scholar 

  102. Moller HJ. Pharmacological and other biological treatments of suicidal individuals. In: Wasserman D, Wasserman C, editors. Oxford textbook of suicidology and suicide prevention: a global perspective. Oxford: Oxford University Press; 2009. p. 395–405.

    Google Scholar 

  103. Fergusson D, Doucette S, Glass KC, Shapiro S, Healy D, Hebert P, Hutton B. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ. 2005;330:396.

    Article  PubMed  CAS  Google Scholar 

  104. Gunnell D, Saperia J, Ashby D. Selective Serotonin Reuptake Inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomized controlled trials submitted to the MHRA’s safety review. BMJ;330:385

  105. http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm096273.ht

  106. Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J. Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord. 2006;8:625–39.

    Article  PubMed  CAS  Google Scholar 

  107. Guzzetta F, Tondo L, Centorrino F, Baldessarini RJ. Lithium treatment reduces suicide risk in recurrent major depressive disorder. J Clin Psychiatry. 2007;68:380–3.

    Article  PubMed  Google Scholar 

  108. Watson WA, Litovitz TL, Klein-Schwartz W, Rodgers Jr GC, Youniss J, Reid N, Rouse WG, Rembert RS, Borys D. 2003 Annual report of the American association of poison control centers toxic exposure surveillance system (TESS). Am J Emerg Med. 2004;22:335–404.

    Article  PubMed  Google Scholar 

  109. Tondo L, Isacsson G, Baldessarini R. Suicidal behavior in bipolar disorder: risk and prevention. CNS Drugs. 2003;17(7):491–511.

    Article  PubMed  CAS  Google Scholar 

  110. Yerevanian B, Koek R, Mintz J. Bipolar pharmacotherapy and suicidal behavior. Part I: Lithium, divalproex and carbamazepine. J Affect Disord. 2007;103:5–11.

    Article  PubMed  CAS  Google Scholar 

  111. Meltzer HY, Baldessarini RJ. Reducing the risk for suicide in schizophrenia and affective disorders. J Clin Psychiatry. 2003;64:1122–9.

    Article  PubMed  Google Scholar 

  112. Spivac B, Shabash E, Sheitman B, Weizman A, Mester R. The effects of clozapine versus haloperidol on measures of impulsive aggression and suicidality in chronic schizophrenia patients: an open, non-randomized, 6-month study. J Clin Psychiatry. 2003;64:755–60.

    Article  Google Scholar 

  113. Moller HJ. Antipsychotic and antidepressive effects of second generation antipsychotics Two different pharmacological mechanisms? Eur Arch Psychiatry Clin Neurosci. 2005;255:190–201.

    Article  PubMed  Google Scholar 

  114. Moller HJ. Antidepressive effects of traditional and second generation antipsychotics: a review of the clinical data. Eur Arch Psychiatry Clin Neurosci. 2005;255:83–93.

    Article  PubMed  Google Scholar 

  115. Kennedy SH, Milev R, Giacobbe P, Ramasubbu R, Lam RW, Parikh SV, Patten SB, Ravindran AV. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. IV. Neurostimulation therapies. J Affect Disord. 2009;117(1):S44–53.

    Article  PubMed  Google Scholar 

  116. Beautrais AL. Subsequent mortality in medically serious suicide attempts: a 5 year follow-up. Aust New Zeal J Psychiatry. 2003;37:595–9.

    Article  Google Scholar 

  117. Suicide attempts in Europe in: Wasserman D, Wasserman C, editors. Oxford Textbook of Suicidology and Suicide Prevention: a Global Perspective. Oxford: Oxford University Press; 2009. p. 123–126

  118. Morgan HG, Jones EM, Owen JH. Secondary prevention of Non-fatal deliberate self-harm the green card study. Br J Psychiatry. 1993;163:111–2.

    Article  PubMed  CAS  Google Scholar 

  119. Carter GL, Clover K, Whyte IM, Dawson AH, D’Este C. Postcards from the EDge project: randomised controlled trial of an intervention using postcards to reduce repetition of hospital treated deliberate self poisoning. BMJ. 2005;331:805.

    Article  PubMed  Google Scholar 

  120. Dieserud G, Loeb M, Ekeberg O. Suicidal behavior in the municipality of Baerum, Norway: a 12-year prospective study of parasuicide and suicide. Suicide Life Threat Behav. 2000;30:61–73.

    PubMed  CAS  Google Scholar 

  121. Family psychoeducation with suicide attempters. In: Wasserman D, Wasserman C, editors. Oxford textbook of suicidology and suicide prevention: a global perspective. Oxford: Oxford University Press; 2009; p. 439–443.

Download references

Acknowledgments

Research on this paper was supported by MH 48514 and the Conte Center for the Neurobiology of Suicidal Behavior MH 62185.

Disclosure

M. Schwartz-Lifshitz: none; G. Zalsman: none; L. Giner has received compensation for development of educational presentations from Servier, Bristol-Myers Squibb, Janssen, and GlaxoSmithKline; has received compensation for travel, accommodations, and meeting expenses from Servier, Bristol-Myers Squibb, Janssen, and GlaxoSmithKline; and has received compensation for development of a presentation from GlaxoSmithKline; M.A. Oquendo receives royalties for the use of the Columbia Suicide Severity Rating Scale; has received financial compensation from Pfizer for the safety evaluation of a clinical facility, unrelated to the current manuscript; was the recipient of a grant from Eli Lilly to support a year’s salary for the Lilly Suicide Scholar, Enrique Baca-Garcia, MD, PhD; and has received unrestricted educational grants and/or lecture fees from AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen, Otsuko, Pfizer, Sanofi-Aventis, and Shire. Her family owns stock in Bristol-Myers Squibb.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maria A. Oquendo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schwartz-Lifshitz, M., Zalsman, G., Giner, L. et al. Can We Really Prevent Suicide?. Curr Psychiatry Rep 14, 624–633 (2012). https://doi.org/10.1007/s11920-012-0318-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11920-012-0318-3

Keywords

Navigation