Skip to main content

Advertisement

Log in

The Role of Muscles in Tension-Type Headache

  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

The tenderness of pericranial myofascial tissues and number of myofascial trigger points are considerably increased in patients with tension-type headache (TTH). Mechanisms responsible for the increased myofascial pain sensitivity have been studied extensively. Peripheral activation or sensitization of myofascial nociceptors could play a role in causing increased pain sensitivity, but firm evidence for a peripheral abnormality still is lacking. Peripheral mechanisms are most likely of major importance in episodic TTH. Sensitization of pain pathways in the central nervous system due to prolonged nociceptive stimuli from pericranial myofascial tissues seem to be responsible for the conversion of episodic to chronic TTH. Treatment directed toward muscular factors include electromyography biofeedback, which has a documented effect in patients with TTH, as well as physiotherapy and muscle relaxation therapy, which are most likely effective. Future studies should aim to identify the source of peripheral nociception.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

  1. Schwartz BS, Stewart WF, Lipton RB. Lost workdays and decreased work effectiveness associated with headache in the workplace. J Occup Environ Med. 1997;39:320–7.

    Article  PubMed  CAS  Google Scholar 

  2. Mathew NT. Tension-type headache. Curr Neurol Neurosci Rep. 2006;6:100–5.

    Article  PubMed  CAS  Google Scholar 

  3. Bendtsen L. Central sensitization in tension-type headache - possible pathophysiological mechanisms. Cephalalgia. 2000;20:486–508.

    Article  PubMed  CAS  Google Scholar 

  4. Bendtsen L, Jensen R. Tension-type headache: the most common, but also the most neglected, headache disorder. Curr Opin Neurol. 2006;19:305–9.

    PubMed  Google Scholar 

  5. Ashina M. Neurobiology of chronic tension-type headache. Cephalalgia. 2004;24:161–72.

    Article  PubMed  CAS  Google Scholar 

  6. Jensen R. Pathophysiological mechanisms of tension-type headache: a review of epidemiological and experimental studies. Cephalalgia. 1999;19:602–21.

    Article  PubMed  CAS  Google Scholar 

  7. Vandenheede M, Schoenen J. Central mechanisms in tension-type headaches. Curr Pain Headache Rep. 2002;6:392–400.

    Article  PubMed  CAS  Google Scholar 

  8. Ashina S, Bendtsen L, Ashina M. Pathophysiology of tension-type headache. Curr Pain Headache Rep. 2005;9:415–22.

    Article  PubMed  Google Scholar 

  9. Fernandez-de-Las-Penas C, Cuadrado ML, Arendt-Nielsen L, Simons DG, Pareja JA. Myofascial trigger points and sensitization: an updated pain model for tension-type headache. Cephalalgia. 2007;27:383–93.

    Article  PubMed  CAS  Google Scholar 

  10. Fumal A, Schoenen J. Tension-type headache: current research and clinical management. Lancet Neurol. 2008;7:70–83.

    Article  PubMed  CAS  Google Scholar 

  11. Bendtsen L, Jensen R. Tension-type headache. Neurol Clin. 2009;27:525–35.

    Article  PubMed  Google Scholar 

  12. Lipchik GL, Holroyd KA, O’Donnell FJ, et al. Exteroceptive suppression periods and pericranial muscle tenderness in chronic tension-type headache: effects of psychopathology, chronicity and disability. Cephalalgia. 2000;20:638–46.

    PubMed  CAS  Google Scholar 

  13. Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Frequency of headache is related to sensitization: a population study. Pain. 2006;123:19–27.

    Article  PubMed  CAS  Google Scholar 

  14. Fernandez-de-Las-Penas C, Cuadrado ML, Arendt-Nielsen L, Ge HY, Pareja JA. Increased pericranial tenderness, decreased pressure pain threshold, and headache clinical parameters in chronic tension-type headache patients. Clin J Pain. 2007;23:346–52.

    Article  PubMed  Google Scholar 

  15. Langemark M, Olesen J. Pericranial tenderness in tension headache. A blind, controlled study. Cephalalgia. 1987;7:249–55.

    Article  PubMed  CAS  Google Scholar 

  16. Jensen R, Bendtsen L, Olesen J. Muscular factors are of importance in tension-type headache. Headache. 1998;38:10–7.

    Article  PubMed  CAS  Google Scholar 

  17. Ashina M, Bendtsen L, Jensen R, Sakai F, Olesen J. Muscle hardness in patients with chronic tension-type headache: relation to actual headache state. Pain. 1999;79:201–5.

    Article  PubMed  CAS  Google Scholar 

  18. Newham DJ, Edwards RHT, Mills KR. Skeletal muscle pain. In: Wall PD, Melzack R, editors. Textbook of pain. 3rd ed. Edinburgh: Churchill Livingstone; 1994. p. 423–40.

    Google Scholar 

  19. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain. 1993;54:241–89.

    Article  PubMed  CAS  Google Scholar 

  20. Jensen R, Olesen J. Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia. 1996;16:175–82.

    Article  PubMed  CAS  Google Scholar 

  21. Christensen M, Bendtsen L, Ashina M, Jensen R. Experimental induction of muscle tenderness and headache in tension-type headache patients. Cephalalgia. 2005;25:1061–7.

    Article  PubMed  CAS  Google Scholar 

  22. Hubbard DR, Berkoff GM. Myofascial trigger points show spontaneous needle EMG activity. Spine. 1993;18:1803–7.

    Article  PubMed  CAS  Google Scholar 

  23. Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Myofascial trigger points and their relationship to headache clinical parameters in chronic tension-type headache. Headache. 2006;46:1264–72.

    Article  PubMed  Google Scholar 

  24. Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Trigger points in the suboccipital muscles and forward head posture in tension-type headache. Headache. 2006;46:454–60.

    Article  PubMed  Google Scholar 

  25. Fernandez-de-Las-Penas C, Cuadrado ML, Pareja JA. Myofascial trigger points, neck mobility, and forward head posture in episodic tension-type headache. Headache. 2007;47:662–72.

    Article  PubMed  Google Scholar 

  26. Fernandez-de-Las-Penas C, Ge HY, Arendt-Nielsen L, Cuadrado ML, Pareja JA. Referred pain from trapezius muscle trigger points shares similar characteristics with chronic tension type headache. Eur J Pain. 2007;11:475–82.

    Article  PubMed  Google Scholar 

  27. Shah JP, Danoff JV, Desai MJ, Parikh S, Nakamura LY, Phillips TM, et al. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil. 2008;89:16–23.

    Article  PubMed  Google Scholar 

  28. Fernandez-de-Las-Penas C, Schoenen J. Chronic tension-type headache: what is new? Curr Opin Neurol. 2009;22:254–61.

    Article  PubMed  Google Scholar 

  29. •• Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Increased pain sensitivity is not a risk factor but a consequence of frequent headache: a population-based follow-up study. Pain. 2008;137:623–30. This is a very important longitudinal study indicating that central sensitization is the consequence of prolonged muscle pain.

    Article  PubMed  CAS  Google Scholar 

  30. Simons DG, Mense S. Understanding and measurement of muscle tone as related to clinical muscle pain. Pain. 1998;75:1–17.

    Article  PubMed  CAS  Google Scholar 

  31. Mense S, Simons DG, Hoheisel U, Quenzer B. Lesions of rat skeletal muscle after local block of acetylcholinesterase and neuromuscular stimulation. J Appl Physiol. 2003;94:2494–501.

    Article  PubMed  CAS  Google Scholar 

  32. Ashina M, Stallknecht B, Bendtsen L, et al. In vivo evidence of altered skeletal muscle blood flow in chronic tension-type headache. Brain. 2002;125:320–6.

    Article  PubMed  CAS  Google Scholar 

  33. Fernandez-Carnero J, Ge HY, Kimura Y, Fernandez-de-Las-Penas C, Arendt-Nielsen L. Increased spontaneous electrical activity at a latent myofascial trigger point after nociceptive stimulation of another latent trigger point. Clin J Pain. 2010;26:138–43.

    Article  PubMed  Google Scholar 

  34. Ashina M, Stallknecht B, Bendtsen L, et al. Tender points are not sites of ongoing inflammation - in vivo evidence in patients with chronic tension-type headache. Cephalalgia. 2003;23:109–16.

    Article  PubMed  CAS  Google Scholar 

  35. Mense S. Differences between myofascial trigger points and tender points. Schmerz. 2011;25:93–103.

    Article  PubMed  CAS  Google Scholar 

  36. Schmidt-Hansen PT, Svensson P, Jensen TS, Graven-Nielsen T, Bach FW. Patterns of experimentally induced pain in pericranial muscles. Cephalalgia. 2006;26:568–77.

    Article  PubMed  CAS  Google Scholar 

  37. Mork H, Ashina M, Bendtsen L, Olesen J, Jensen R. Possible mechanisms of pain perception in patients with episodic tension-type headache. A new experimental model of myofascial pain. Cephalalgia. 2004;24:466–75.

    Article  PubMed  CAS  Google Scholar 

  38. Göbel H, Weigle L, Kropp P, Soyka D. Pain sensitivity and pain reactivity of pericranial muscles in migraine and tension-type headache. Cephalalgia. 1992;12:142–51.

    Article  PubMed  Google Scholar 

  39. Jensen R, Rasmussen BK, Pedersen B, Olesen J. Muscle tenderness and pressure pain thresholds in headache. A population study. Pain. 1993;52:193–9.

    Article  PubMed  CAS  Google Scholar 

  40. Bovim G. Cervicogenic headache, migraine, and tension-type headache. Pressure-pain threshold measurements. Pain. 1992;51:169–73.

    Article  PubMed  CAS  Google Scholar 

  41. Jensen R. Mechanisms of spontaneous tension-type headaches: an analysis of tenderness, pain thresholds and EMG. Pain. 1996;64:251–6.

    Article  PubMed  CAS  Google Scholar 

  42. Schmidt-Hansen PT, Svensson P, Bendtsen L, Graven-Nielsen T, Bach FW. Increased muscle pain sensitivity in patients with tension-type headache. Pain. 2007;129:113–21.

    Article  PubMed  Google Scholar 

  43. Mork H, Ashina M, Bendtsen L, Olesen J, Jensen R. Induction of prolonged tenderness in patients with tension-type headache by means of a new experimental model of myofascial pain. Eur J Neurol. 2003;10:249–56.

    Article  PubMed  CAS  Google Scholar 

  44. Bendtsen L, Jensen R, Olesen J. Decreased pain detection and tolerance thresholds in chronic tension-type headache. Arch Neurol. 1996;53:373–6.

    PubMed  CAS  Google Scholar 

  45. Langemark M, Jensen K, Jensen TS, Olesen J. Pressure pain thresholds and thermal nociceptive thresholds in chronic tension-type headache. Pain. 1989;38:203–10.

    Article  PubMed  CAS  Google Scholar 

  46. Langemark M, Bach FW, Jensen TS, Olesen J. Decreased nociceptive flexion reflex threshold in chronic tension-type headache. Arch Neurol. 1993;50:1061–4.

    PubMed  CAS  Google Scholar 

  47. Schoenen J, Bottin D, Hardy F, Gerard P. Cephalic and extracephalic pressure pain thresholds in chronic tension-type headache. Pain. 1991;47:145–9.

    Article  PubMed  CAS  Google Scholar 

  48. Sandrini G, Rossi P, Milanov I, Serrao M, Cecchini AP, Nappi G. Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients. Cephalalgia. 2006;26:782–9.

    Article  PubMed  CAS  Google Scholar 

  49. Ashina S, Bendtsen L, Ashina M, Magerl W, Jensen R. Generalized hyperalgesia in patients with chronic tension-type headache. Cephalalgia. 2006;26:940–8.

    Article  PubMed  CAS  Google Scholar 

  50. Lindelof K, Ellrich J, Jensen R, Bendtsen L. Central pain processing in chronic tension-type headache. Clin Neurophysiol. 2009;120:1364–70.

    Article  PubMed  Google Scholar 

  51. Cathcart S, Winefield AH, Lushington K, Rolan P. Noxious inhibition of temporal summation is impaired in chronic tension-type headache. Headache. 2010;50:403–12.

    Article  PubMed  Google Scholar 

  52. Cathcart S, Winefield AH, Lushington K, Rolan P. Effect of mental stress on cold pain in chronic tension-type headache sufferers. J Headache Pain. 2009;10:367–73.

    Article  PubMed  Google Scholar 

  53. Buchgreitz L, Lyngberg A, Bendtsen L, Jensen R. Increased prevalence of tension-type headache over a 12-year period is related to increased pain sensitivity. A population study. Cephalalgia. 2007;27:145–52.

    Article  PubMed  CAS  Google Scholar 

  54. Treede RD, Meyer RA, Raja SN, Campbell JN. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol. 1992;38:397–421.

    Article  PubMed  CAS  Google Scholar 

  55. Milanov I, Bogdanova D. Pain and tension-type headache: a review of the possible pathophysiological mechanisms. J Headache Pain. 2004;5:4–11.

    Article  Google Scholar 

  56. Bendtsen L, Jensen R, Olesen J. Qualitatively altered nociception in chronic myofascial pain. Pain. 1996;65:259–64.

    Article  PubMed  CAS  Google Scholar 

  57. Srbely JZ, Dickey JP, Bent LR, Lee D, Lowerison M. Capsaicin-induced central sensitization evokes segmental increases in trigger point sensitivity in humans. J Pain. 2010;11:636–43.

    Article  PubMed  CAS  Google Scholar 

  58. Pielsticker A, Haag G, Zaudig M, Lautenbacher S. Impairment of pain inhibition in chronic tension-type headache. Pain. 2005;118:215–23.

    Article  PubMed  Google Scholar 

  59. Buchgreitz L, Egsgaard LL, Jensen R, Arendt-Nielsen L, Bendtsen L. Abnormal pain processing in chronic tension-type headache: a high-density EEG brain mapping study. Brain. 2008;131:3232–8.

    Article  PubMed  CAS  Google Scholar 

  60. Merskey H. Pain and psychological medicine. In: Wall PD, Melzack R, editors. Textbook of pain. 3rd ed. Edinburgh: Churchill Livingstone; 1994. p. 903–20.

    Google Scholar 

  61. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 1993;52:259–85.

    Article  PubMed  CAS  Google Scholar 

  62. •• Cathcart S, Winefield AH, Lushington K, Rolan P. Stress and tension-type headache mechanisms. Cephalalgia. 2010;30:1250–67. This is an interesting series of studies on the relation between stress and headache.

    Article  PubMed  Google Scholar 

  63. Cathcart S, Petkov J, Winefield AH, Lushington K, Rolan P. Central mechanisms of stress-induced headache. Cephalalgia. 2010;30:285–95.

    Article  PubMed  CAS  Google Scholar 

  64. Penacoba-Puente C, Fernandez-de-Las-Penas C, Gonzalez-Gutierrez JL, Miangolarra-Page JC, Pareja JA. Interaction between anxiety, depression, quality of life and clinical parameters in chronic tension-type headache. Eur J Pain. 2008;12:886–94.

    Article  PubMed  Google Scholar 

  65. Schmidt-Wilcke T, Leinisch E, Straube A, Kampfe N, Draganski B, Diener HC, et al. Gray matter decrease in patients with chronic tension type headache. Neurology. 2005;65:1483–6.

    Article  PubMed  CAS  Google Scholar 

  66. Bendtsen L. Sensitization: its role in primary headache. Curr Opin Investig Drugs. 2002;3:449–53.

    PubMed  CAS  Google Scholar 

  67. Bendtsen L, Jensen R. Amitriptyline reduces myofascial tenderness in patients with chronic tension-type headache. Cephalalgia. 2000;20:603–10.

    Article  PubMed  CAS  Google Scholar 

  68. Meller ST, Gebhart GF. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain. 1993;52:127–36.

    Article  PubMed  CAS  Google Scholar 

  69. Ashina M, Bendtsen L, Jensen R, Olesen J. Nitric oxide-induced headache in patients with chronic tension-type headache. Brain. 2000;123:1830–7.

    Article  PubMed  Google Scholar 

  70. Ashina M, Lassen LH, Bendtsen L, Jensen R, Olesen J. Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial. Lancet. 1999;353:287–9.

    Article  PubMed  CAS  Google Scholar 

  71. Ashina M, Bendtsen L, Jensen R, Lassen LH, Sakai F, Olesen J. Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache. Brain. 1999;122:1629–35.

    Article  PubMed  Google Scholar 

  72. Sarchielli P, Alberti A, Floridi A, Gallai V. L-Arginine/nitric oxide pathway in chronic tension-type headache: relation with serotonin content and secretion and glutamate content. J Neurol Sci. 2002;198:9–15.

    Article  PubMed  CAS  Google Scholar 

  73. Makowska A, Panfil C, Ellrich J. Long-term potentiation of orofacial sensorimotor processing by noxious input from the semispinal neck muscle in mice. Cephalalgia. 2005;25:109–16.

    Article  PubMed  CAS  Google Scholar 

  74. Makowska A, Panfil C, Ellrich J. Nerve growth factor injection into semispinal neck muscle evokes sustained facilitation of the jaw-opening reflex in anesthetized mice – possible implications for tension-type headache. Exp Neurol. 2005;191:301–9.

    Article  PubMed  CAS  Google Scholar 

  75. Makowska A, Panfil C, Ellrich J. ATP induces sustained facilitation of craniofacial nociception through P2X receptors on neck muscle nociceptors in mice. Cephalalgia. 2006;26:697–706.

    Article  PubMed  CAS  Google Scholar 

  76. Panfil C, Makowska A, Ellrich J. Brainstem and cervical spinal cord Fos immunoreactivity evoked by nerve growth factor injection into neck muscles in mice. Cephalalgia. 2006;26:128–35.

    Article  PubMed  CAS  Google Scholar 

  77. •• Bendtsen L, Evers S, Linde M, Mitsikostas DD, Sandrini G, Schoenen J. EFNS guideline on the treatment of tension-type headache - report of an EFNS task force. Eur J Neurol. 2010;17:1318–25. This is an important guideline on the treatment of tension-type headache.

    PubMed  CAS  Google Scholar 

  78. Nestoriuc Y, Rief W, Martin A. Meta-analysis of biofeedback for tension-type headache: efficacy, specificity, and treatment moderators. J Consult Clin Psychol. 2008;76:379–96.

    Article  PubMed  Google Scholar 

  79. Soderberg EI, Carlsson JY, Stener-Victorin E, Dahlof C. Subjective well-being in patients with chronic tension-type headache: Effect of acupuncture, physical training, and relaxation training. Clin J Pain. 2011 Feb 11.

Download references

Acknowledgements

Springer would like to thank Dr. Katherine Henry, Section Editor of the Tension-type Headache section, for her proposal and review of this article.

Disclosures

Dr. Lars Bendtsen has served as a board member for Berlin-Chemie and Allergan, and as a consultant for Pfizer and Merck & Co. C. Fernández-de-la-Peñas: none.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lars Bendtsen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bendtsen, L., Fernández-de-la-Peñas, C. The Role of Muscles in Tension-Type Headache. Curr Pain Headache Rep 15, 451–458 (2011). https://doi.org/10.1007/s11916-011-0216-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11916-011-0216-0

Keywords

Navigation