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Epigenetics of Sleep and Chronobiology

  • Sleep (M Thorpy, M Billiard, Section Editors)
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Abstract

The circadian clock choreographs fundamental biological rhythms. This system is comprised of the master circadian pacemaker in the suprachiasmatic nucleus and associated pacemakers in other tissues that coordinate complex physiological processes and behaviors, such as sleep, feeding, and metabolism. The molecular circuitry that underlies these clocks and orchestrates circadian gene expression has been the focus of intensive investigation, and it is becoming clear that epigenetic factors are highly integrated into these networks. In this review, we draw attention to the fundamental roles played by epigenetic mechanisms in transcriptional and post-transcriptional regulation within the circadian clock system. We also highlight how alterations in epigenetic factors and mechanisms are being linked with sleep-wake disorders. These observations provide important insights into the pathogenesis and potential treatment of these disorders and implicate epigenetic deregulation in the significant but poorly understood interconnections now emerging between circadian processes and neurodegeneration, metabolic diseases, cancer, and aging.

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Conflict of Interest

Irfan A. Qureshi declares that he has no conflict of interest. Mark F. Mehler is supported by grants from the National Institutes of Health (NS071571, HD071593, MH66290), as well as by the F.M. Kirby, Alpern Family, Harold and Isabel Feld and Roslyn and Leslie Goldstein Foundations.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Irfan A. Qureshi & Mark F. Mehler

  2. Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Irfan A. Qureshi & Mark F. Mehler

  3. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Irfan A. Qureshi & Mark F. Mehler

  4. Departments of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Mark F. Mehler

  5. Departments of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Mark F. Mehler

  6. Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Room 401, Bronx, NY, 10461, USA

    Irfan A. Qureshi & Mark F. Mehler

  7. Ruth S. and David L. Gottesman Stem Cell Institute, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Mark F. Mehler

  8. Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Mark F. Mehler

  9. Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Mark F. Mehler

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  1. Irfan A. Qureshi
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Correspondence to Mark F. Mehler.

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Qureshi, I.A., Mehler, M.F. Epigenetics of Sleep and Chronobiology. Curr Neurol Neurosci Rep 14, 432 (2014). https://doi.org/10.1007/s11910-013-0432-6

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