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The role of HNF4A variants in the risk of type 2 diabetes

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Abstract

Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping recently identified a likely susceptibility gene, hepatocyte nuclear factor 4-α (HNF4A). Rare loss-of-function mutations in HNF4A cause maturityonset diabetes of the young and now common noncoding variants have been found to be associated with T2DM.

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  1. Department of Genetics, University of North Carolina, 103 Mason Farm Drive, CB 7264, 27599-7264, Chapel Hill, NC, USA

    Karen L. Mohlke PhD

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Mohlke, K.L., Boehnke, M. The role of HNF4A variants in the risk of type 2 diabetes. Curr Diab Rep 5, 149–156 (2005). https://doi.org/10.1007/s11892-005-0043-y

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