Skip to main content
SpringerLink
Log in

Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions

  • Published:
Reaction Kinetics and Catalysis Letters Aims and scope Submit manuscript

Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea using copper(II) trifluoroacetate as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction condition, this new method has the advantage of good to excellent yields and short reaction time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. Biginelli: Gazz. Chim. Ital., 23, 360 (1893).

    Google Scholar 

  2. Q. Sun, Y.Q. Wang, Z.M. Ge, T.M. Cheng, R.T. Li: Synthesis, 1047 (2004).

  3. H. Salehi, Q.X. Guo: Synth. Commun., 34, 171 (2004).

    Article  CAS  Google Scholar 

  4. S.J. Tu, F. Fang, S.L. Zhu, T.J. Li, X.J. Zhang, Q.Y. Zhuang: Synlett, 537 (2004).

  5. A. Shaabani, A. Bazgir, F. Teimouri: Tetrahedron Lett., 44, 857 (2003).

    Article  CAS  Google Scholar 

  6. N.Y. Fu, Y.F. Yuan, Z. Cao, S.W. Wang, J.T. Wang, C. Peppe: Tetrahedron, 58, 4801 (2002).

    Article  CAS  Google Scholar 

  7. J. Lu, H.R. Ma: Synlett, 63 (2000).

  8. S. Xue, Y.C. Shen, Y.L. Li, X.M. Shen, Q.X. Guo: Chin. J. Chem., 20, 385 (2002).

    CAS  Google Scholar 

  9. D.B.D. Amico, D. Boschi, F. Calderazzo, L. Labella, F Marchetti: Inorg. Chim. Acta., 330, 149 (2002).

    Article  Google Scholar 

  10. S.A. Krupoder, V.S. Danilovich, A.O. Miller, G.G. Furin: J. Flourine Chem., 73, 13 (1995).

    Article  CAS  Google Scholar 

  11. A.R. Khosropour, M.M. Khodaei, K. Ghozati: Chem. Lett., 33, 304 (2004).

    Article  CAS  Google Scholar 

  12. H. Adibi, H.A. Samimi, M. Beygzadeh: Catal. Commun., 8, 2119 (2007).

    Article  CAS  Google Scholar 

  13. A.S. Paraskar, G.K. Dewkar, A. Sudalai: Tetrahedron Lett., 44, 3305 (2003).

    Article  CAS  Google Scholar 

  14. M. Gohain, D. Prajapati, J.S. Sandhu: Synlett, 235 (2004).

  15. N. Yanagihara, T. Gotoh, T. Ogura: Polyhedron, 15, 4349 (1996).

    Article  CAS  Google Scholar 

  16. M. Wang, H. Jiang, Z.C. Wang: J. Chem. Res., 11, 691 (2005).

    Article  Google Scholar 

  17. J.T. Li, J.F. Han, J.H. Yang, T.S. Li: Ultrason. Sonochem., 10, 119 (2003).

    Article  CAS  Google Scholar 

  18. H. Xu, Y.G. Wang: J. Chem. Res., 377 (2003).

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, School of Chemistry and Materials Science, Liaoning Shihua University, Fushun, Liaoning, 113001, People’s Republic of China

    Dailei Song, Runxia Wang, Yongli Chen, Shaohua Zhang, Chunsheng Liu & Genxiang Luo

Authors
  1. Dailei Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Runxia Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yongli Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shaohua Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chunsheng Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Genxiang Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Genxiang Luo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Song, D., Wang, R., Chen, Y. et al. Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions. React Kinet Catal Lett 95, 385–390 (2008). https://doi.org/10.1007/s11144-008-5379-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11144-008-5379-2

Keywords

Search

Navigation