Abstract
Purpose
To examine autoimmune disorders in patients with IgA deficiency compared with the general population.
Methods
Nationwide prospective population-based cohort study. Through six university hospitals in Sweden we identified 2100 individuals with IgA deficiency (IgA levels < .07 g/L) diagnosed between 1980 and 2011. Each patient with IgA deficiency was matched on age, sex, place of residence, and year of diagnosis with up to 10 general population controls (n = 18,653). Data on nine autoimmune disorders were retrieved from the Swedish National Patient Register (including inpatient and non-primary outpatient care). Autoimmune disorders were defined as having at least two visits listing the relevant international classification of disease (ICD) code as main diagnosis. Prevalences and prevalence ratios (PRs) were calculated.
Results
Individuals with IgA deficiency more often had celiac disease (6.7 % vs. 0.19 % in controls) and type 1 diabetes (5.9 % vs. 0.57 %) corresponding to a 35-fold higher PR for celiac disease and 10-fold higher for type 1 diabetes. Also for the other autoimmune diseases did we see statistically significantly elevated prevalences and PRs (juvenile idiopathic arthritis (0.76 % vs. 0.09 % in controls, PR = 8.9), systemic lupus erythematosus (0.57 % vs. 0.06 %; PR = 8.9), inflammatory bowel disease (3.9 % vs. 0.81 %; PR = 5.0; specifically Crohn’s disease (2.4 % vs. 0.42 %; PR = 5.7) and ulcerative colitis (1.7 % vs. 0.46 %; PR = 3.9)), hypothyreosis (0.76 % vs. 0.16 %; PR = 4.6), rheumatoid arthritis (2.2 % vs. 0.50 %; PR = 4.5), and hyperthyreosis (1.7 % vs. 0.43 %; PR = 3.9), but not with myasthenia gravis (0.05 % vs. 0.02 %; PR = 3.0).
Conclusions
Individuals with IgA deficiency have a higher prevalence of several other autoimmune disorders.
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Abbreviations
- PR:
-
Prevalence ratio
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Acknowledgments
Conflict of Interest
The authors (JFL, MN, LH) declare that they have no conflicts of interest relevant to the contents of this manuscript.
Details of Contributors
Dr Ludvigsson and Dr Neovius had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Ludvigsson
Acquisition of data: Hammarström
Drafting of the manuscript: Ludvigsson, Neovius
Critical revision of the manuscript for important intellectual content: Hammarström, Ludvigsson, Neovius
Statistical analysis: Ludvigsson, Neovius
Obtained funding: Hammarström
Study supervision: Ludvigsson, Hammarström
Ethical Approval
This project (2011/69-31/3) was approved by the Regional Ethical Review Board in Stockholm on Feb 23, 2011. This was a register-based study and therefore all data were anonymised prior to analysis, and we were not allowed to contact the patients.
Funding
JFL was supported by grants from the Swedish Society of Medicine, and the Swedish Research Council; MN: None; LH: Swedish Research Council.
Statement of Independence of Researchers from Funders
No person representing the funding sources read or commented on any version of the manuscript.
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Ludvigsson, J.F., Neovius, M. & Hammarström, L. Association Between IgA Deficiency & Other Autoimmune Conditions: A Population-Based Matched Cohort Study. J Clin Immunol 34, 444–451 (2014). https://doi.org/10.1007/s10875-014-0009-4
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DOI: https://doi.org/10.1007/s10875-014-0009-4