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Dysphagia Associated with Gastroesophageal Reflux Disease Is Improved by Proton Pump Inhibitor

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Abstract

This study aimed to determine whether dysphagia associated with gastroesophageal reflux disease was effectively treated with rabeprazole, a proton pump inhibitor. Sixty-eight outpatients with gastroesophageal reflux-associated dysphagia were enrolled in this study. Endoscopic esophagitis was confirmed in 52 of 68 subjects. The proton pump inhibitor rabeprazole was administered at 20 mg daily for 8 weeks. Rabeprazole was administered for a further 6 months to 16 subjects whose dysphagia was improved (10 mg/day) and 5 of these underwent 24-hr esophageal pH monitoring before and after treatment. Dysphagia was completely resolved in 40 of 68 subjects, which were categorized in Group I. Dysphagia improved partially in 20 subjects and was unchanged in 8 subjects. These 28 subjects were categorized into Group II. Comparison was made between Group I and Group II and multivariate analysis demonstrated that the only factor that correlated with the effect of rabeprazole on dysphagia was “improvement in heartburn symptoms.” There were no relapses of symptoms during the 6-month follow-up period, and pH monitoring showed sustained suppression of acid secretion.The results indicate that rabeprazole is effective in the treatment of dysphagia associated with gastroesophageal reflux disease. We were, however, unable to elicit any factors that could predict the therapeutic effect of rabeprazole before commencing treatment.

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Authors and Affiliations

  1. Departments of Internal Medicine, Saga Medical School, Saga, 849-8501, Japan

    Kayoko Oda Md, Ryuichi Iwakiri Md, Kazuyo Watanabe Md, Akiko Danjo, Ryo Shimoda Md, Atsushi Kikkawa Md, Akifumi Ootani Md, Hiroyuki Sakata MD & Seiji Tsunada Md

  2. Community Health Science, Saga Medical School, Saga, 849-8501, Japan

    Megumi Hara Md

  3. Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima Saga, Saga, 849-8501, Japan

    Kazuma Fujimoto Md

Authors
  1. Kayoko Oda Md
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  2. Ryuichi Iwakiri Md
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  3. Megumi Hara Md
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  4. Kazuyo Watanabe Md
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  5. Akiko Danjo
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  6. Ryo Shimoda Md
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  7. Atsushi Kikkawa Md
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  8. Akifumi Ootani Md
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  9. Hiroyuki Sakata MD
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  10. Seiji Tsunada Md
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  11. Kazuma Fujimoto Md
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Correspondence to Kazuma Fujimoto Md.

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Oda, K., Iwakiri, R., Hara, M. et al. Dysphagia Associated with Gastroesophageal Reflux Disease Is Improved by Proton Pump Inhibitor. Dig Dis Sci 50, 1921–1926 (2005). https://doi.org/10.1007/s10620-005-2962-5

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  • DOI: https://doi.org/10.1007/s10620-005-2962-5

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