Skip to main content

Advertisement

SpringerLink
Log in

Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

  • Rapid Communication
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004.

Methods

Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed.

Results

Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively.

Conclusions

The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T Berge F Linell (1976) ArticleTitleCarcinoid tumours. Frequency in a defined population during a 12-year period Acta Pathol Microbiol Scand [A] 84 322–30 Occurrence Handle1:STN:280:CSmB2svltVQ%3D

    CAS  Google Scholar 

  2. K Oberg B Eriksson (2005) ArticleTitleEndocrine tumours of the pancreas Best Pract Res Clin Gastroenterol 19 753–81 Occurrence Handle16253899 Occurrence Handle10.1016/j.bpg.2005.06.002 Occurrence Handle1:CAS:528:DC%2BD2MXhtFKntrfN

    Article  PubMed  CAS  Google Scholar 

  3. B Eriksson K Oberg (2000) ArticleTitleNeuroendocrine tumours of the pancreas Br J Surg 87 129–31 Occurrence Handle10671915 Occurrence Handle10.1046/j.1365-2168.2000.01277.x Occurrence Handle1:STN:280:DC%2BD3c7jslygtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  4. KY Lam CY Lo (1997) ArticleTitlePancreatic endocrine tumour: a 22-year clinico-pathological experience with morphological, immunohistochemical observation and a review of the literature Eur J Surg Oncol 23 36–42 Occurrence Handle9066745 Occurrence Handle10.1016/S0748-7983(97)80140-0 Occurrence Handle1:STN:280:ByiB3MbksVE%3D

    Article  PubMed  CAS  Google Scholar 

  5. RE Moldow RR Connelly (1968) ArticleTitleEpidemiology of pancreatic cancer in Connecticut Gastroenterology 55 677–86 Occurrence Handle4302500 Occurrence Handle1:STN:280:CCaD28nnt1c%3D

    PubMed  CAS  Google Scholar 

  6. U Plockinger G Rindi R Arnold B Eriksson EP Krenning WW de Herder et al. (2004) ArticleTitleGuidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS) Neuroendocrinology 80 394–424 Occurrence Handle15838182 Occurrence Handle10.1159/000085237 Occurrence Handle1:CAS:528:DC%2BD2MXksVKqurg%3D

    Article  PubMed  CAS  Google Scholar 

  7. K Oberg L Astrup B Eriksson SE Falkmer UG Falkmer J Gustafsen et al. (2004) ArticleTitleGuidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part I-general overview Acta Oncol 43 617–25 Occurrence Handle15545182 Occurrence Handle10.1080/02841860410018575

    Article  PubMed  Google Scholar 

  8. K Oberg L Astrup B Eriksson SE Falkmer UG Falkmer J Gustafsen et al. (2004) ArticleTitleGuidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part II-specific NE tumour types Acta Oncol 43 626–36 Occurrence Handle15545183 Occurrence Handle10.1080/02841860410018584

    Article  PubMed  Google Scholar 

  9. J Soga Y Yakuwa M Osaka (1999) ArticleTitleCarcinoid syndrome: a statistical evaluation of 748 reported cases J Exp Clin Cancer Res 18 133–41 Occurrence Handle10464698 Occurrence Handle1:STN:280:DyaK1Mzptl2ltg%3D%3D

    PubMed  CAS  Google Scholar 

  10. J Soga (2005) ArticleTitleEarly-stage carcinoids of the gastrointestinal tract: an analysis of 1914 reported cases Cancer 15 IssueID103 1587–95 Occurrence Handle10.1002/cncr.20939

    Article  Google Scholar 

  11. K Oberg (2003) ArticleTitleDiagnosis and treatment of carcinoid tumors Expert Rev Anticancer Ther 3 863–77 Occurrence Handle14686708 Occurrence Handle10.1586/14737140.3.6.863

    Article  PubMed  Google Scholar 

  12. MH Kulke RJ Mayer (1999) ArticleTitleCarcinoid tumors N Engl J Med 340 858–68 Occurrence Handle10080850 Occurrence Handle10.1056/NEJM199903183401107 Occurrence Handle1:STN:280:DyaK1M7msFehsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. IM Modlin KD Lye M Kidd (2003) ArticleTitleA 5-decade analysis of 13,715 carcinoid tumors Cancer 9 934–59 Occurrence Handle10.1002/cncr.11105

    Article  Google Scholar 

  14. IM Modlin I Latich M Zikusoka M Kidd G Eick AK Chan (2006) ArticleTitleGastrointestinal carcinoids: the evolution of diagnostic strategies J Clin Gastroenterol 40 572–82 Occurrence Handle16917396 Occurrence Handle10.1097/00004836-200608000-00003

    Article  PubMed  Google Scholar 

  15. LK Kvols ML Brown MK O'Connor JC Hung RJ Hayostek JC Reubi et al. (1993) ArticleTitleEvaluation of a radiolabeled somatostatin analog (I-123 octreotide) in the detection and localization of carcinoid and islet cell tumors Radiology 187 129–33 Occurrence Handle8383865 Occurrence Handle1:STN:280:ByyC1MjkvFU%3D

    PubMed  CAS  Google Scholar 

  16. F Gibril RT Jensen (2004) ArticleTitleDiagnostic uses of radiolabelled somatostatin receptor analogues in gastroenteropancreatic endocrine tumours Dig Liver Dis 36 S106–20 Occurrence Handle15077919 Occurrence Handle10.1016/j.dld.2003.11.024 Occurrence Handle1:CAS:528:DC%2BD2cXjsFOns7w%3D

    Article  PubMed  CAS  Google Scholar 

  17. B Termanini F Gibril JC Reynolds JL Doppman CC Chen CA Stewart et al. (1997) ArticleTitleValue of somatostatin receptor scintigraphy: a prospective study in gastrinoma of its effect on clinical management Gastroenterology 112 335–47 Occurrence Handle9024287 Occurrence Handle10.1053/gast.1997.v112.pm9024287 Occurrence Handle1:STN:280:ByiC2snnsVw%3D

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Tetsuhide Ito, Ken Kawabe & Kazuhiko Nakamura

  2. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Masao Tanaka

  3. Department of Pathology, Tohoku University School of Medicine, Sendai, Japan

    Hironobu Sasano

  4. Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan

    Yoshiyuki R. Osamura

  5. Department of Surgery, Tohoku Graduate School of Medicine, Sendai, Japan

    Iwao Sasaki

  6. Department of Gastroenterological and General Surgery, Course of Organ Functions and Controls, Yamagata University School of Medicine, Yamagata, Japan

    Wataru Kimura

  7. Department of Nephrology and Endocrinology, University of Tokyo Faculty of Medicine, Tokyo, Japan

    Koji Takano

  8. Department of Endocrine Surgery, Tokyo Women's Medical University, Tokyo, Japan

    Takao Obara

  9. Department of Medicine, Takatsu General Hospital, Kawasaki, Japan

    Miyuki Ishibashi

  10. Department of Medicine and Clinical Science, Division of Endocrinology and Metabolism, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Kazuwa Nakao

  11. Department of Surgery, Kyoto University, Kyoto, Japan

    Ryuichiro Doi

  12. Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

    Akira Shimatsu

  13. Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Toshirou Nishida

  14. Department of Surgery, Osaka Saiseikai Noe Hospital, Osaka, Japan

    Izumi Komoto & Masayuki Imamura

  15. Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

    Yukio Hirata

Authors
  1. Tetsuhide Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masao Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hironobu Sasano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiyuki R. Osamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Iwao Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wataru Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Koji Takano
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takao Obara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Miyuki Ishibashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kazuwa Nakao
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Ryuichiro Doi
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Akira Shimatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Toshirou Nishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Izumi Komoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Yukio Hirata
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Masayuki Imamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Ken Kawabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Kazuhiko Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

The Neuroendocrine Tumor Workshop of Japan

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ito, T., Tanaka, M., Sasano, H. et al. Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors. J Gastroenterol 42, 497–500 (2007). https://doi.org/10.1007/s00535-007-2056-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00535-007-2056-6

Key words

Search

Navigation