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Laparoscopic and open splenectomy for splenomegaly secondary to liver cirrhosis: an evaluation of immunity

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Abstract

Objective

We sought to investigate the perioperative inflammatory response and immunological function of patients with portal hypertension-induced splenomegaly who underwent laparoscopic (LS) or open splenectomy (OS).

Methods

This prospective study investigated a total of 34 patients with splenomegaly due to portal hypertension who underwent either LS (n = 18) or OS (n = 16) between May 2009 and September 2010. Peripheral venous blood samples were taken from these patients prior to surgery and on postoperative days (POD) 1, 3, and 7. The perioperative clinical outcomes and immunological function results were analyzed and compared within each surgical group.

Results

The demographics of the two groups did not differ. The patients in the LS group experienced longer operating time, less intraoperative blood loss, earlier resumption of diet, and shorter postoperative hospital stay. Both the open and laparoscopic groups exhibited statistically significant differences in interleukin -6 and C-reactive protein levels, and total lymphocyte, CD4 T, and natural killer cell numbers on POD 1 and 3 compared with pre splenectomy. The immune responses in the LS group were significantly lower than those in the OS group. The LS group exhibited better preserved cellular immune response and faster recovery than the OS group on POD 7.

Conclusions

An examination of the inflammatory reaction and cellular immune response after LS and OS demonstrated that there are significant differences in the immune responses observed in the two groups. Further human studies are required to determine the permanent effects of LS on immune function.

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Acknowledgments

This study was sponsored by Scientific and Technical Supporting Program of Sichuan Province (2011FZ0014).

Disclosures

Zhong Wu, Jin Zhou, Prasoon Pankaj and Bing Peng have no conflicts of interest or financial ties to disclose.

Author information

Authors and Affiliations

  1. Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China

    Zhong Wu, Prasoon Pankaj & Bing Peng

  2. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China

    Jin Zhou

Authors
  1. Zhong Wu
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  2. Jin Zhou
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  3. Prasoon Pankaj
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  4. Bing Peng
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Corresponding author

Correspondence to Bing Peng.

Additional information

Drs. Zhong Wu and Jin Zhou contributed equally to this work.

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Wu, Z., Zhou, J., Pankaj, P. et al. Laparoscopic and open splenectomy for splenomegaly secondary to liver cirrhosis: an evaluation of immunity. Surg Endosc 26, 3557–3564 (2012). https://doi.org/10.1007/s00464-012-2366-5

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  • DOI: https://doi.org/10.1007/s00464-012-2366-5

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