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Inheritance of chronic tension-type headache investigated by complex segregation analysis

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Abstract

We investigated the mode of inheritance of chronic tension-type headache in 122 families. The probands were from the Copenhagen Headache Clinic, Denmark. The criteria of the International Headache Society were used. The patterns of segregation of chronic tension-type headache were assessed by complex segregation analysis performed with the computer program POINTER. Of the 122 probands with chronic tension-type headache, 56 had 71 first-degree relatives with chronic tension-type headache. The complex segregation analysis indicates that chronic tension-type headache has multifactorial inheritance.

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Authors and Affiliations

  1. Department of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark Fax: +45-43-23-39-26, , , , , , DK

    Michael Bjørn Russell, Steen Østergaard & Jes Olesen

  2. Department of Surgery, Karolinska Hospital, Stockholm, Sweden, , , , , , SE

    Lennart Iselius

Authors
  1. Michael Bjørn Russell
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  2. Lennart Iselius
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  3. Steen Østergaard
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  4. Jes Olesen
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Received: 22 April 1997 / Accepted: 4 September 1997

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Russell, M., Iselius, L., Østergaard, S. et al. Inheritance of chronic tension-type headache investigated by complex segregation analysis. Hum Genet 102, 138–140 (1998). https://doi.org/10.1007/s004390050666

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  • DOI: https://doi.org/10.1007/s004390050666

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