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CT compared to MRI for functional evaluation of the right ventricle: a systematic review and meta-analysis

  • Cardiac
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A Correction to this article was published on 25 March 2020

This article has been updated

Abstract

Objective

Right ventricular function (RVF) is a strong predictor of adverse cardiac events; however, the reference standard for RVF assessment, MRI, is limited in some patients for whom accurate evaluation of RVF is essential, like those with COPD or non-MR compatible metal implants. We conducted this meta-analysis to evaluate whether CT was as accurate as MRI for the assessment of RVF.

Method

We conducted a meta-analysis of studies retrieved from PubMed, Embase, and Cochrane Central searches to evaluate the differences and correlations between the following RVF parameters as measured by CT and MRI: end diastole volume (EDV), end systole volume (ESV), right ventricular ejection fraction (RVEF), and stroke volume (SV).

Results

Sixteen studies that used disk summation (637 subjects) and three studies that used three-dimensional reconstruction were included. For the 16 studies, the pooled standard mean differences (95% confidence interval) were 1.04 (− 2.59, 4.67) for EDV, 1.22 (1.50, 3.95) for ESV, − 0.65 (− 2.60, 1.29) for RVEF, and − 0.37 (− 3.64, 2.90) for SV. The overall correlation coefficient (r) values were 0.98 for EDV, 0.95 for ESV, 0.98 for RVEF, and 0.97 for SV. The mean difference between the two methods was not statistically significant (overall effect Z test, p > 0.1).

Conclusion

CT can assess RVF with accuracy comparable to that of MRI. Thus, CT is a valid alternative to MRI.

Key Points

• CT could help clinicians to assess RVF as accurately as MRI can, with satisfactory repeatability.

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Change history

  • 25 March 2020

    The original version of this article, published on 27 May 2019, unfortunately contained mistakes.

Abbreviations

CI:

Confidence interval

CT:

Computed tomography

EDV:

End diastole volume

ESV:

End systole volume

LOA:

Limit of agreement

MD:

Mean difference

MR:

Magnetic resonance

MRI:

Magnetic resonance imaging

QUADAS:

The Quality Assessment of Diagnostic Studies

RV:

Right ventricular

RVEF:

Right ventricular ejection fraction

RVF:

Right ventricular function

SD:

Standard deviation

SV:

Stroke volume

TR:

Temporary resolution

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Funding

This work was supported by the National Natural Science Foundation of China (81471722, 81771887, 81471721, 81771897) and Program for Young Scholars and Innovative Research Team in Sichuan Province of China (2017TD0005).

Author information

Author notes

  1. Hang Fu and Xuedong Wang contributed equally to this work and should be considered the co-first authors.

Authors and Affiliations

  1. Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, 610041, Sichuan, China

    Hang Fu, Hui Liu & Ying-kun Guo

  2. Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

    Xuedong Wang

  3. Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China

    Kaiyue Diao, Shan Huang, Yue Gao, Qin Zhao & Zhi-gang Yang

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  1. Hang Fu
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Corresponding authors

Correspondence to Zhi-gang Yang or Ying-kun Guo.

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Guarantor

The scientific guarantor of this publication is Ying-kun Guo.

Conflict of interest

The authors report no conflicts of interest.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was not required for this study because it is a meta-analysis.

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Institutional Review Board approval was not required because of the meta-analysis study design.

Study subjects or cohorts overlap

Study subjects and cohorts have been reported previously as detailed in the methods and results as well as reference.

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• Performed at one institution

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Fu, H., Wang, X., Diao, K. et al. CT compared to MRI for functional evaluation of the right ventricle: a systematic review and meta-analysis. Eur Radiol 29, 6816–6828 (2019). https://doi.org/10.1007/s00330-019-06228-2

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