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Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy

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Abstract

Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.

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Abbreviations

CNP:

C-type natriuretic peptide

NPR-B:

natriuretic peptide receptor B

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Acknowledgements

This work was supported by a grant from Deutsche Forschungsgemeinschaft (BA 1374/14-1). The authors would like to acknowledge the critical review and discussion of this manuscript by Dr. Daniel Schwartz (NHLBI, NIH).

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Authors and Affiliations

  1. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Ines Pagel-Langenickel

  2. Max Delbrueck Center for Molecular Medicine Berlin-Buch, Berlin, Germany

    Jens Buttgereit & Michael Bader

  3. Vascular Biology Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Building 50, Room 4529, Bethesda, MD, 20892, USA

    Thomas H. Langenickel

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  1. Ines Pagel-Langenickel
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Correspondence to Thomas H. Langenickel.

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Pagel-Langenickel, I., Buttgereit, J., Bader, M. et al. Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy. J Mol Med 85, 797–810 (2007). https://doi.org/10.1007/s00109-007-0183-4

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  • DOI: https://doi.org/10.1007/s00109-007-0183-4

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