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Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys

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Summary

  1. 1.

    A fixed interval-fixed ratio chain of behavior was maintained for periods as long as 6 months by intravenously administered morphine.

  2. 2.

    The morphine reinforced FI-FR chain was found to be a sensitive and reliable index of motivational changes induced by drug deprivation, nalorphine antagonism and pretreatment with morphine.

  3. 3.

    Profound behavioral disruption occurred in both shock avoidance and food reinforced ratio behavior under conditions of drug deprivation.

  4. 4.

    The behavioral disruption of the food reinforced and shock avoidance behaviors was ameliorated by a single self-administration of morphine. Substitution of saline for the morphine solution produced a transitory placebo effect characterized by an immediate return of the food and avoidance behaviors to their pre-deprivation baseline conditions, but followed by progressive disruption as time without the drug increased.

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References

  • Davis, W. M., and J. R. Nichols: Physical dependence and sustained opiate-directed behavior in the rat. Psychopharmacologia (Berl.) 3, 139 (1962).

    Google Scholar 

  • Nichols, J. R., and W. M. Davis: Drug addiction II. Variation of addiction. J. Amer. pharm. Ass. 48, 259 (1959).

    Google Scholar 

  • —, C. P. Headlee and H. W. Coppock: Drug addiction 1. Addiction by escape training. J. Amer. pharm. Ass. 45, 788 (1956).

    Google Scholar 

  • Niemann, W. H., C. R. Schuster and T. Thompson: A surgical preparation for chronic intravenous infusion in Rhesus monkeys. University of Maryland, Laboratory of Psychopharmacology Technical Report No. 62-39, September, 1962.

  • Schuster, C. R., and T. Thompson: Self-administration of morphine in physically dependent monkeys. University of Maryland, Laboratory of Psychopharmacology Technical Report No. 62-29, July, 1962.

  • Seevers, M. H.: Opiate addiction in monkeys; methods of study. J. Pharmacol. exp. Ther. 56, 147 (1936).

    Google Scholar 

  • —: Ch. 19 in Pharmacology in Medicine (V. A. Drill, ed.). New York: McGraw-Hill Book Co. 1958.

    Google Scholar 

  • Weeks, J. R.: Self-maintained morphine “addiction” — A method for chronic programmed intravenous injection in unrestrained rats. Fed. Proc. 20, 397 (1961) (abst).

    Google Scholar 

  • —: Experimental morphine addiction: Method for automatic intravenous injections in unrestrained rats. Science 138, 143 (1962).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Psychopharmacology, University of Maryland, College Park, Maryland

    Travis Thompson &  Charles R. Schuster

  2. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA

    Charles R. Schuster

Authors
  1. Travis Thompson
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  2. Charles R. Schuster
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Additional information

This research was supported by research grant MY-1604 from the National Institute of Mental Health and grant NsG 189-61 from the National Aeronautics and Space Administration, to the University of Maryland.

National Science Foundation post-doctoral fellow 41088.

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Thompson, T., Schuster, C.R. Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacologia 5, 87–94 (1964). https://doi.org/10.1007/BF00413045

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  • DOI: https://doi.org/10.1007/BF00413045

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